RNA interference-mediated silencing of Kv7.2 in rat dorsal root ganglion neurons abolishes the anti-nociceptive effect of a selective channel opener

Development of agonistic analgesic drugs requires proof of selectivity in vivo attainable by selective antagonists or several knockdown strategies. The Kv7.2 potassium channel encoded by the KCNQ2 gene regulates neuronal excitability and its activation inhibits nociceptive transmission. Although it...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2020-05, Vol.103, p.106693-106693, Article 106693
Hauptverfasser:	Valdor, Markus, Wagner, Anke, Fischer, Heike, Röhrs, Viola, Schröder, Wolfgang, Bahrenberg, Gregor, Welbers, André, Fechner, Henry, Kurreck, Jens, Tzschentke, Thomas M., Christoph, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus (AAV) Analgesics Animals Benzamides Dorsal root ganglion (DRG) Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Gene Knockdown Techniques KCNQ2 Potassium Channel - genetics KCNQ2 Potassium Channel - metabolism Kv7.2 Male Methods Neurons Nociceptors Pyridines Rat Rats Rats, Sprague-Dawley RNA Interference
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