Liver X receptor inhibition potentiates mitotane-induced adrenotoxicity in ACC

Adrenocortical carcinoma (ACC) is a rare aggressive malignancy with a poor outcome largely due to limited treatment options. Here, we propose a novel therapeutic approach through modulating intracellular free cholesterol via the liver X receptor alpha (LXRα) in combination with current first-line ph...

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Veröffentlicht in:	Endocrine-related cancer 2020-06, Vol.27 (6), p.361-373
Hauptverfasser:	Warde, Kate M, Schoenmakers, Erik, Ribes Martinez, Eduardo, Lim, Yi Jan, Leonard, Maeve, Lawless, Sarah J, O’Shea, Paula, Chatterjee, Krishna V, Gurnell, Mark, Hantel, Constanze, Dennedy, Michael Conall
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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