Ansamycin derivatives from the marine-derived Streptomyces sp. SCSGAA 0027 and their cytotoxic and antiviral activities

[Display omitted] Fourteen ansamycin derivatives including seven new herbimycins G–L (1–6) and divergolide O (7), and seven known analogues were isolated from a culture broth of the marine-derived Streptomyces sp. SCSGAA 0027. Their complete structures were determined by detailed analysis of spectro...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2020-06, Vol.30 (11), p.127168-127168, Article 127168
Hauptverfasser:	Nong, Xu-Hua, Tu, Zheng-Chao, Qi, Shu-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Ansamycin anti-HSV-1 activity Antiviral Agents - chemistry Antiviral Agents - pharmacology Cell Line, Tumor Cell Survival - drug effects Cytotoxicity Divergolide Drug Screening Assays, Antitumor Herbimycin Herpesvirus 1, Human - drug effects HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - metabolism Hsp90 inhibition Humans Magnetic Resonance Spectroscopy Molecular Conformation Rifabutin - analogs & derivatives Rifabutin - pharmacology Staphylococcus aureus - drug effects Stereoisomerism Streptomyces - chemistry Streptomyces - metabolism Streptomyces sp Structure-Activity Relationship
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