Incidence trends of vulvar squamous cell carcinoma in Italy from 1990 to 2015
The incidence of vulvar squamous cell carcinoma has increased for decades in most Western countries – a trend virtually restricted to women aged
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| Veröffentlicht in: | Gynecologic oncology 2020-06, Vol.157 (3), p.656-663 |
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| creator | Mancini, Silvia Bucchi, Lauro Baldacchini, Flavia Giuliani, Orietta Ravaioli, Alessandra Vattiato, Rosa Preti, Mario Tumino, Rosario Ferretti, Stefano Biggeri, Annibale Brustolin, Angelita Boschetti, Lorenza Caiazzo, Anna L. Caldarella, Adele Cesaraccio, Rosaria Cirilli, Claudia Citarella, Annarita Filiberti, Rosa A. Fusco, Mario Galasso, Rocco Gatti, Luciana Lotti, Fernanda L. Magoni, Michele Mangone, Lucia Masanotti, Giuseppe Mazzoleni, Guido Mazzucco, Walter Melcarne, Anna Michiara, Maria Pesce, Paola Piffer, Silvano Pinto, Angela Rognoni, Magda Rosso, Stefano Rugge, Massimo Sampietro, Giuseppe Scalzi, Santo Scuderi, Tiziana Tagliabue, Giovanna Tisano, Francesco Toffolutti, Federica Vitarelli, Susanna Falcini, Fabio |
| description | The incidence of vulvar squamous cell carcinoma has increased for decades in most Western countries – a trend virtually restricted to women aged |
| doi_str_mv | 10.1016/j.ygyno.2020.03.013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2388814352</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0090825820302298</els_id><sourcerecordid>2388814352</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-aae39b16f73064f4cce45f7121aaf9324b40ae1dd649a6df17a7e46f7c9c4e553</originalsourceid><addsrcrecordid>eNp9kD1v2zAQhokiQe24_QUFAo5ZpB6_JHHoUBhJY8BFlnYmaOpY0JBEm5QM-N9XjpOOnW553rv3HkK-MCgZsOrrvjz_OQ-x5MChBFECEx_IkoFWRdUofUOWABqKhqtmQe5y3gOAAMY_koXgvBZM6yX5uRlcaHFwSMeEQ5tp9PQ0dSebaD5Oto9Tpg67jjqbXBhib2kY6Ga03Zn6FHs6rwE6RsqBqU_k1tsu4-e3uSK_nx5_rZ-L7cuPzfr7tnBC6bGwFoXescrXAirppXMola8ZZ9Z6LbjcSbDI2raS2latZ7WtUc64006iUmJFHq57DykeJ8yj6UO-tLQDzoUNF03TMCkUn1FxRV2KOSf05pBCb9PZMDAXj2ZvXj2ai0cDwswe59T924Fp12P7L_Mubga-XQGc3zwFTCa7cNHYhoRuNG0M_z3wF--gg7c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2388814352</pqid></control><display><type>article</type><title>Incidence trends of vulvar squamous cell carcinoma in Italy from 1990 to 2015</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Mancini, Silvia ; Bucchi, Lauro ; Baldacchini, Flavia ; Giuliani, Orietta ; Ravaioli, Alessandra ; Vattiato, Rosa ; Preti, Mario ; Tumino, Rosario ; Ferretti, Stefano ; Biggeri, Annibale ; Brustolin, Angelita ; Boschetti, Lorenza ; Caiazzo, Anna L. ; Caldarella, Adele ; Cesaraccio, Rosaria ; Cirilli, Claudia ; Citarella, Annarita ; Filiberti, Rosa A. ; Fusco, Mario ; Galasso, Rocco ; Gatti, Luciana ; Lotti, Fernanda L. ; Magoni, Michele ; Mangone, Lucia ; Masanotti, Giuseppe ; Mazzoleni, Guido ; Mazzucco, Walter ; Melcarne, Anna ; Michiara, Maria ; Pesce, Paola ; Piffer, Silvano ; Pinto, Angela ; Rognoni, Magda ; Rosso, Stefano ; Rugge, Massimo ; Sampietro, Giuseppe ; Scalzi, Santo ; Scuderi, Tiziana ; Tagliabue, Giovanna ; Tisano, Francesco ; Toffolutti, Federica ; Vitarelli, Susanna ; Falcini, Fabio</creator><creatorcontrib>Mancini, Silvia ; Bucchi, Lauro ; Baldacchini, Flavia ; Giuliani, Orietta ; Ravaioli, Alessandra ; Vattiato, Rosa ; Preti, Mario ; Tumino, Rosario ; Ferretti, Stefano ; Biggeri, Annibale ; Brustolin, Angelita ; Boschetti, Lorenza ; Caiazzo, Anna L. ; Caldarella, Adele ; Cesaraccio, Rosaria ; Cirilli, Claudia ; Citarella, Annarita ; Filiberti, Rosa A. ; Fusco, Mario ; Galasso, Rocco ; Gatti, Luciana ; Lotti, Fernanda L. ; Magoni, Michele ; Mangone, Lucia ; Masanotti, Giuseppe ; Mazzoleni, Guido ; Mazzucco, Walter ; Melcarne, Anna ; Michiara, Maria ; Pesce, Paola ; Piffer, Silvano ; Pinto, Angela ; Rognoni, Magda ; Rosso, Stefano ; Rugge, Massimo ; Sampietro, Giuseppe ; Scalzi, Santo ; Scuderi, Tiziana ; Tagliabue, Giovanna ; Tisano, Francesco ; Toffolutti, Federica ; Vitarelli, Susanna ; Falcini, Fabio ; AIRTUM Working Group</creatorcontrib><description>The incidence of vulvar squamous cell carcinoma has increased for decades in most Western countries – a trend virtually restricted to women aged <50 or 60 years. In southern Europe, conversely, the trends have been insufficiently studied. This article reports a study from Italy.
Thirty-eight local cancer registries, currently covering 15,274,070 women, equivalent to 49.2% of the Italian national female population, participated. Invasive cancers registered between 1990 and 2015 with an International Classification of Diseases for Oncology, 3rd revision, topography code C51 and morphology codes compatible with vulvar squamous cell carcinoma (n = 6294) were eligible. Incidence trends were analysed using joinpoint regression models, with calculation of the estimated annual percent change (EAPC), and age-period-cohort models.
Total incidence showed a regular and significant decreasing trend (EAPC, −0.96; 95% confidence interval (CI), −1.43 to −0.48). This was entirely accounted for by women aged ≥60 years (EAPC, −1.34; 95% CI, −1.86 to −0.81). For younger women, the EAPC between 1990 and 2012 was 1.20 (95% CI, 0.34 to 2.06) with a non-significant acceleration thereafter. This pattern did not vary substantially in a sensitivity analysis for the effect of geographic area and duration of the registry. The age-period-cohort analysis revealed a risk decrease in cohorts born between 1905 and 1940 and a new increase in cohorts born since 1945.
The decreasing trend observed among older women and the resulting decrease in total rate are at variance with reports from most Western countries. Age-period-cohort analysis confirmed a decreasing trend for earliest birth cohorts and an opposite one for recent ones.
•In southern Europe, the trends in the incidence of vulvar squamous cell carcinoma have been insufficiently studied.•In Italy, 38 local cancer registries covering 15 millions women provided incidence data for the period 1990–2015.•An unexpected decreasing incidence trend among women aged ≥60 years resulted in a decrease in total rate.•The risk dropped in all cohorts of women born between 1905 and 1940 while rising in the cohorts born since 1945.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1016/j.ygyno.2020.03.013</identifier><identifier>PMID: 32273199</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age-period-cohort modelling ; Carcinoma, Squamous Cell - epidemiology ; Female ; History, 20th Century ; History, 21st Century ; Humans ; Incidence ; Italy ; Middle Aged ; Trend ; Vulvar neoplasms ; Vulvar Neoplasms - epidemiology</subject><ispartof>Gynecologic oncology, 2020-06, Vol.157 (3), p.656-663</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-aae39b16f73064f4cce45f7121aaf9324b40ae1dd649a6df17a7e46f7c9c4e553</citedby><cites>FETCH-LOGICAL-c359t-aae39b16f73064f4cce45f7121aaf9324b40ae1dd649a6df17a7e46f7c9c4e553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0090825820302298$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32273199$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mancini, Silvia</creatorcontrib><creatorcontrib>Bucchi, Lauro</creatorcontrib><creatorcontrib>Baldacchini, Flavia</creatorcontrib><creatorcontrib>Giuliani, Orietta</creatorcontrib><creatorcontrib>Ravaioli, Alessandra</creatorcontrib><creatorcontrib>Vattiato, Rosa</creatorcontrib><creatorcontrib>Preti, Mario</creatorcontrib><creatorcontrib>Tumino, Rosario</creatorcontrib><creatorcontrib>Ferretti, Stefano</creatorcontrib><creatorcontrib>Biggeri, Annibale</creatorcontrib><creatorcontrib>Brustolin, Angelita</creatorcontrib><creatorcontrib>Boschetti, Lorenza</creatorcontrib><creatorcontrib>Caiazzo, Anna L.</creatorcontrib><creatorcontrib>Caldarella, Adele</creatorcontrib><creatorcontrib>Cesaraccio, Rosaria</creatorcontrib><creatorcontrib>Cirilli, Claudia</creatorcontrib><creatorcontrib>Citarella, Annarita</creatorcontrib><creatorcontrib>Filiberti, Rosa A.</creatorcontrib><creatorcontrib>Fusco, Mario</creatorcontrib><creatorcontrib>Galasso, Rocco</creatorcontrib><creatorcontrib>Gatti, Luciana</creatorcontrib><creatorcontrib>Lotti, Fernanda L.</creatorcontrib><creatorcontrib>Magoni, Michele</creatorcontrib><creatorcontrib>Mangone, Lucia</creatorcontrib><creatorcontrib>Masanotti, Giuseppe</creatorcontrib><creatorcontrib>Mazzoleni, Guido</creatorcontrib><creatorcontrib>Mazzucco, Walter</creatorcontrib><creatorcontrib>Melcarne, Anna</creatorcontrib><creatorcontrib>Michiara, Maria</creatorcontrib><creatorcontrib>Pesce, Paola</creatorcontrib><creatorcontrib>Piffer, Silvano</creatorcontrib><creatorcontrib>Pinto, Angela</creatorcontrib><creatorcontrib>Rognoni, Magda</creatorcontrib><creatorcontrib>Rosso, Stefano</creatorcontrib><creatorcontrib>Rugge, Massimo</creatorcontrib><creatorcontrib>Sampietro, Giuseppe</creatorcontrib><creatorcontrib>Scalzi, Santo</creatorcontrib><creatorcontrib>Scuderi, Tiziana</creatorcontrib><creatorcontrib>Tagliabue, Giovanna</creatorcontrib><creatorcontrib>Tisano, Francesco</creatorcontrib><creatorcontrib>Toffolutti, Federica</creatorcontrib><creatorcontrib>Vitarelli, Susanna</creatorcontrib><creatorcontrib>Falcini, Fabio</creatorcontrib><creatorcontrib>AIRTUM Working Group</creatorcontrib><title>Incidence trends of vulvar squamous cell carcinoma in Italy from 1990 to 2015</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>The incidence of vulvar squamous cell carcinoma has increased for decades in most Western countries – a trend virtually restricted to women aged <50 or 60 years. In southern Europe, conversely, the trends have been insufficiently studied. This article reports a study from Italy.
Thirty-eight local cancer registries, currently covering 15,274,070 women, equivalent to 49.2% of the Italian national female population, participated. Invasive cancers registered between 1990 and 2015 with an International Classification of Diseases for Oncology, 3rd revision, topography code C51 and morphology codes compatible with vulvar squamous cell carcinoma (n = 6294) were eligible. Incidence trends were analysed using joinpoint regression models, with calculation of the estimated annual percent change (EAPC), and age-period-cohort models.
Total incidence showed a regular and significant decreasing trend (EAPC, −0.96; 95% confidence interval (CI), −1.43 to −0.48). This was entirely accounted for by women aged ≥60 years (EAPC, −1.34; 95% CI, −1.86 to −0.81). For younger women, the EAPC between 1990 and 2012 was 1.20 (95% CI, 0.34 to 2.06) with a non-significant acceleration thereafter. This pattern did not vary substantially in a sensitivity analysis for the effect of geographic area and duration of the registry. The age-period-cohort analysis revealed a risk decrease in cohorts born between 1905 and 1940 and a new increase in cohorts born since 1945.
The decreasing trend observed among older women and the resulting decrease in total rate are at variance with reports from most Western countries. Age-period-cohort analysis confirmed a decreasing trend for earliest birth cohorts and an opposite one for recent ones.
•In southern Europe, the trends in the incidence of vulvar squamous cell carcinoma have been insufficiently studied.•In Italy, 38 local cancer registries covering 15 millions women provided incidence data for the period 1990–2015.•An unexpected decreasing incidence trend among women aged ≥60 years resulted in a decrease in total rate.•The risk dropped in all cohorts of women born between 1905 and 1940 while rising in the cohorts born since 1945.</description><subject>Age-period-cohort modelling</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Female</subject><subject>History, 20th Century</subject><subject>History, 21st Century</subject><subject>Humans</subject><subject>Incidence</subject><subject>Italy</subject><subject>Middle Aged</subject><subject>Trend</subject><subject>Vulvar neoplasms</subject><subject>Vulvar Neoplasms - epidemiology</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1v2zAQhokiQe24_QUFAo5ZpB6_JHHoUBhJY8BFlnYmaOpY0JBEm5QM-N9XjpOOnW553rv3HkK-MCgZsOrrvjz_OQ-x5MChBFECEx_IkoFWRdUofUOWABqKhqtmQe5y3gOAAMY_koXgvBZM6yX5uRlcaHFwSMeEQ5tp9PQ0dSebaD5Oto9Tpg67jjqbXBhib2kY6Ga03Zn6FHs6rwE6RsqBqU_k1tsu4-e3uSK_nx5_rZ-L7cuPzfr7tnBC6bGwFoXescrXAirppXMola8ZZ9Z6LbjcSbDI2raS2latZ7WtUc64006iUmJFHq57DykeJ8yj6UO-tLQDzoUNF03TMCkUn1FxRV2KOSf05pBCb9PZMDAXj2ZvXj2ai0cDwswe59T924Fp12P7L_Mubga-XQGc3zwFTCa7cNHYhoRuNG0M_z3wF--gg7c</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Mancini, Silvia</creator><creator>Bucchi, Lauro</creator><creator>Baldacchini, Flavia</creator><creator>Giuliani, Orietta</creator><creator>Ravaioli, Alessandra</creator><creator>Vattiato, Rosa</creator><creator>Preti, Mario</creator><creator>Tumino, Rosario</creator><creator>Ferretti, Stefano</creator><creator>Biggeri, Annibale</creator><creator>Brustolin, Angelita</creator><creator>Boschetti, Lorenza</creator><creator>Caiazzo, Anna L.</creator><creator>Caldarella, Adele</creator><creator>Cesaraccio, Rosaria</creator><creator>Cirilli, Claudia</creator><creator>Citarella, Annarita</creator><creator>Filiberti, Rosa A.</creator><creator>Fusco, Mario</creator><creator>Galasso, Rocco</creator><creator>Gatti, Luciana</creator><creator>Lotti, Fernanda L.</creator><creator>Magoni, Michele</creator><creator>Mangone, Lucia</creator><creator>Masanotti, Giuseppe</creator><creator>Mazzoleni, Guido</creator><creator>Mazzucco, Walter</creator><creator>Melcarne, Anna</creator><creator>Michiara, Maria</creator><creator>Pesce, Paola</creator><creator>Piffer, Silvano</creator><creator>Pinto, Angela</creator><creator>Rognoni, Magda</creator><creator>Rosso, Stefano</creator><creator>Rugge, Massimo</creator><creator>Sampietro, Giuseppe</creator><creator>Scalzi, Santo</creator><creator>Scuderi, Tiziana</creator><creator>Tagliabue, Giovanna</creator><creator>Tisano, Francesco</creator><creator>Toffolutti, Federica</creator><creator>Vitarelli, Susanna</creator><creator>Falcini, Fabio</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202006</creationdate><title>Incidence trends of vulvar squamous cell carcinoma in Italy from 1990 to 2015</title><author>Mancini, Silvia ; Bucchi, Lauro ; Baldacchini, Flavia ; Giuliani, Orietta ; Ravaioli, Alessandra ; Vattiato, Rosa ; Preti, Mario ; Tumino, Rosario ; Ferretti, Stefano ; Biggeri, Annibale ; Brustolin, Angelita ; Boschetti, Lorenza ; Caiazzo, Anna L. ; Caldarella, Adele ; Cesaraccio, Rosaria ; Cirilli, Claudia ; Citarella, Annarita ; Filiberti, Rosa A. ; Fusco, Mario ; Galasso, Rocco ; Gatti, Luciana ; Lotti, Fernanda L. ; Magoni, Michele ; Mangone, Lucia ; Masanotti, Giuseppe ; Mazzoleni, Guido ; Mazzucco, Walter ; Melcarne, Anna ; Michiara, Maria ; Pesce, Paola ; Piffer, Silvano ; Pinto, Angela ; Rognoni, Magda ; Rosso, Stefano ; Rugge, Massimo ; Sampietro, Giuseppe ; Scalzi, Santo ; Scuderi, Tiziana ; Tagliabue, Giovanna ; Tisano, Francesco ; Toffolutti, Federica ; Vitarelli, Susanna ; Falcini, Fabio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-aae39b16f73064f4cce45f7121aaf9324b40ae1dd649a6df17a7e46f7c9c4e553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age-period-cohort modelling</topic><topic>Carcinoma, Squamous Cell - 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In southern Europe, conversely, the trends have been insufficiently studied. This article reports a study from Italy.
Thirty-eight local cancer registries, currently covering 15,274,070 women, equivalent to 49.2% of the Italian national female population, participated. Invasive cancers registered between 1990 and 2015 with an International Classification of Diseases for Oncology, 3rd revision, topography code C51 and morphology codes compatible with vulvar squamous cell carcinoma (n = 6294) were eligible. Incidence trends were analysed using joinpoint regression models, with calculation of the estimated annual percent change (EAPC), and age-period-cohort models.
Total incidence showed a regular and significant decreasing trend (EAPC, −0.96; 95% confidence interval (CI), −1.43 to −0.48). This was entirely accounted for by women aged ≥60 years (EAPC, −1.34; 95% CI, −1.86 to −0.81). For younger women, the EAPC between 1990 and 2012 was 1.20 (95% CI, 0.34 to 2.06) with a non-significant acceleration thereafter. This pattern did not vary substantially in a sensitivity analysis for the effect of geographic area and duration of the registry. The age-period-cohort analysis revealed a risk decrease in cohorts born between 1905 and 1940 and a new increase in cohorts born since 1945.
The decreasing trend observed among older women and the resulting decrease in total rate are at variance with reports from most Western countries. Age-period-cohort analysis confirmed a decreasing trend for earliest birth cohorts and an opposite one for recent ones.
•In southern Europe, the trends in the incidence of vulvar squamous cell carcinoma have been insufficiently studied.•In Italy, 38 local cancer registries covering 15 millions women provided incidence data for the period 1990–2015.•An unexpected decreasing incidence trend among women aged ≥60 years resulted in a decrease in total rate.•The risk dropped in all cohorts of women born between 1905 and 1940 while rising in the cohorts born since 1945.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32273199</pmid><doi>10.1016/j.ygyno.2020.03.013</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-8258 |
| ispartof | Gynecologic oncology, 2020-06, Vol.157 (3), p.656-663 |
| issn | 0090-8258 1095-6859 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2388814352 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Age-period-cohort modelling Carcinoma, Squamous Cell - epidemiology Female History, 20th Century History, 21st Century Humans Incidence Italy Middle Aged Trend Vulvar neoplasms Vulvar Neoplasms - epidemiology |
| title | Incidence trends of vulvar squamous cell carcinoma in Italy from 1990 to 2015 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T06%3A49%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Incidence%20trends%20of%20vulvar%20squamous%20cell%20carcinoma%20in%20Italy%20from%201990%20to%202015&rft.jtitle=Gynecologic%20oncology&rft.au=Mancini,%20Silvia&rft.aucorp=AIRTUM%20Working%20Group&rft.date=2020-06&rft.volume=157&rft.issue=3&rft.spage=656&rft.epage=663&rft.pages=656-663&rft.issn=0090-8258&rft.eissn=1095-6859&rft_id=info:doi/10.1016/j.ygyno.2020.03.013&rft_dat=%3Cproquest_cross%3E2388814352%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2388814352&rft_id=info:pmid/32273199&rft_els_id=S0090825820302298&rfr_iscdi=true |