Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides

Ruthenium‐catalysed azide–alkyne cycloaddition (RuAAC) provides access to 1,5‐disubstituted 1,2,3‐triazole motifs in peptide engineering applications. However, investigation of this motif as a disulfide mimetic in cyclic peptides has been limited, and the structural consequences remain to be studied...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-07, Vol.59 (28), p.11273-11277
Hauptverfasser:	White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas, Craik, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Amino Acid Sequence Backbone Crystallography Crystallography, X-Ray Cyclization Cycloaddition disulfide mimetics Disulfides - chemistry inhibitors Linkages Molecular Mimicry NMR Nuclear magnetic resonance Nuclear Magnetic Resonance, Biomolecular Peptides Peptides, Cyclic - chemistry peptidomimetics Protease inhibitors Proteinase inhibitors Ruthenium Ruthenium - chemistry Serine Serine proteinase Structural analysis Sunflowers triazole bridges Triazoles Triazoles - chemistry Trypsin Trypsin inhibitors
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