A DNA tetrahedron-based molecular computation device for the logic sensing of dual microRNAs in living cells
Endogenous miRNA expression patterns are specific to cell type and thus offer high prediction accuracy with regard to different cell identities compared to single miRNA analysis. The "AND" logic gate can be utilized as a DNA computation device that recognizes dual-miRNA inputs through stra...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2020-05, Vol.56 (39), p.533-536 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Lin, Qing Wang, Anmin Liu, Shiyuan Li, Jing Wang, Jiaoli Quan, Ke Yang, Xiaohai Huang, Jin Wang, Kemin |
| description | Endogenous miRNA expression patterns are specific to cell type and thus offer high prediction accuracy with regard to different cell identities compared to single miRNA analysis. The "AND" logic gate can be utilized as a DNA computation device that recognizes dual-miRNA inputs through strand hybridization activated computation cascades to produce controlled outputs. To integrate all recognition and computing modules within a single structure, a DNA tetrahedron-based molecular device was constructed for the logic sensing of dual miRNAs in living cells.
Endogenous miRNA expression patterns are specific to cell type and thus offer high prediction accuracy with regard to different cell identities compared to single miRNA analysis. |
| doi_str_mv | 10.1039/d0cc01231a |
| format | Article |
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Endogenous miRNA expression patterns are specific to cell type and thus offer high prediction accuracy with regard to different cell identities compared to single miRNA analysis.</description><subject>Cell Line</subject><subject>Cells (biology)</subject><subject>Computation</subject><subject>Computers, Molecular</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - chemistry</subject><subject>HEK293 Cells</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Logic circuits</subject><subject>MicroRNAs</subject><subject>MicroRNAs - analysis</subject><subject>Molecular structure</subject><subject>Optical Imaging</subject><subject>Tetrahedra</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9rFTEQx4Motj69eFciXkRYTTL7Izkur1oLpYIoeFtmk9k2Jbt5JrsF_3v3-WoLHjqXGfh-mF9fxl5K8UEKMB-dsFZIBRIfsWMJdVlUpf75eF9XpmigrI7Ys5yvxRqy0k_ZESjVSIDqmIWWn1y0fKY54RW5FKeix0yOjzGQXQImbuO4W2acfZy4oxtviQ8x8fmKeIiX3vJMU_bTJY8DdwsGPnqb4reLNnM_8eBv9pqlEPJz9mTAkOnFbd6wH58_fd9-Kc6_np5t2_PCQg1zYbRTOIAoEVH2slGuKRswA1oyClBoV1srSVNTo5DYN0YpNAa1RYDa9LBh7w59dyn-WijP3ejzfgOcKC65U6C1EKpZp23Y2__Q67ikad2uU6VQpSqN0iv1_kCth-WcaOh2yY-YfndSdHsPuhOx3f71oF3h17ctl34kd4f-e_oKvDoAKds79d7EVX_zkN7t3AB_AFq5lhQ</recordid><startdate>20200514</startdate><enddate>20200514</enddate><creator>Lin, Qing</creator><creator>Wang, Anmin</creator><creator>Liu, Shiyuan</creator><creator>Li, Jing</creator><creator>Wang, Jiaoli</creator><creator>Quan, Ke</creator><creator>Yang, Xiaohai</creator><creator>Huang, Jin</creator><creator>Wang, Kemin</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8122-7140</orcidid><orcidid>https://orcid.org/0000-0002-2890-682X</orcidid><orcidid>https://orcid.org/0000-0001-9390-4938</orcidid></search><sort><creationdate>20200514</creationdate><title>A DNA tetrahedron-based molecular computation device for the logic sensing of dual microRNAs in living cells</title><author>Lin, Qing ; 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The "AND" logic gate can be utilized as a DNA computation device that recognizes dual-miRNA inputs through strand hybridization activated computation cascades to produce controlled outputs. To integrate all recognition and computing modules within a single structure, a DNA tetrahedron-based molecular device was constructed for the logic sensing of dual miRNAs in living cells.
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| ispartof | Chemical communications (Cambridge, England), 2020-05, Vol.56 (39), p.533-536 |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Cell Line Cells (biology) Computation Computers, Molecular Deoxyribonucleic acid DNA DNA - chemistry HEK293 Cells HeLa Cells Humans Logic circuits MicroRNAs MicroRNAs - analysis Molecular structure Optical Imaging Tetrahedra |
| title | A DNA tetrahedron-based molecular computation device for the logic sensing of dual microRNAs in living cells |
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