Tuning the immune reaction to manipulate the cell-mediated degradation of a collagen barrier membrane

In order to elicit a desired barrier function in guided bone regeneration (GBR) or guided tissue regeneration (GTR), a barrier membrane has to maintain its integrity for a certain period of time to guarantee the regeneration of target tissue. Due to the complexity and variety of clinical conditions,...

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Veröffentlicht in:	Acta biomaterialia 2020-06, Vol.109, p.95-108
Hauptverfasser:	Fang, Jinghan, Liu, Runheng, Chen, Shoucheng, Liu, Quan, Cai, Huaxiong, Lin, Yixiong, Chen, Zetao, Chen, Zhuofan
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorbable Implants Animals Barrier membrane Biomaterials Biomedical materials Bone growth Cell activation Collagen Collagen - chemistry Collagen - immunology Collagen - metabolism Cytokines Degradation Foreign body giant cells GBR Giant cells Giant Cells, Foreign-Body - immunology Giant Cells, Foreign-Body - metabolism GTR Immune response Immune system Immunity, Cellular - drug effects Immunologic Factors - pharmacology Immunomodulation Implantation In vivo methods and tests Interleukin 13 Interleukin-13 - antagonists & inhibitors Interleukin-13 - metabolism Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lymphocytes T Male Membrane degradation Membranes Membranes, Artificial Phagocytes Rats, Wistar Receptors, Interleukin-4, Type II - metabolism Regeneration Regeneration (physiology) Surgical implants Swine Th2 Cells - metabolism Tissue engineering Tissues
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