Functionalized halloysite multivalent glycocluster as a new drug delivery system

A new design for halloysite nanotube materials was obtained by grafting chemically modified cyclodextrin units onto the nanotube surface. In particular, grafted cyclodextrins were decorated with thiosaccharide pendants, in order to mimic the well-known binding of sugars to proteins and the glyco-clu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2014-11, Vol.2 (44), p.7732-7738
Hauptverfasser:	Massaro, M, Riela, S, Lo Meo, P, Noto, R, Cavallaro, G, Milioto, S, Lazzara, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Cellular Cyclodextrins Drug delivery systems Grafting Jewelry Light scattering Mathematical models Nanostructure
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	7738
container_issue	44
container_start_page	7732
container_title	Journal of materials chemistry. B, Materials for biology and medicine
container_volume	2
creator	Massaro, M Riela, S Lo Meo, P Noto, R Cavallaro, G Milioto, S Lazzara, G
description	A new design for halloysite nanotube materials was obtained by grafting chemically modified cyclodextrin units onto the nanotube surface. In particular, grafted cyclodextrins were decorated with thiosaccharide pendants, in order to mimic the well-known binding of sugars to proteins and the glyco-cluster effect occurring during cellular recognition events. The obtained materials were characterized by using a combination of varied techniques (FT-IR spectroscopy, thermogravimetric analysis, scanning electron microscopy, dynamic light scattering, turbidimetry), and their potential drug-delivery abilities were tested by studying their interactions with the common naturally occurring anticancer agent curcumin. A suitable model describing the interaction between our materials and curcumin is proposed.
doi_str_mv	10.1039/c4tb01272k
format	Article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2387680699</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2387680699</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-aafc897bf81fed28711c0719e5a1db460678264fc9674df5571c8ab2d52e1a333</originalsourceid><addsrcrecordid>eNqFkctOwzAQRS0EolXphg9AXiKkgh-JH0uoKCAqwaJI7CLHdkrASYrtFIWvJ9DSbWczI83Rnau5AJxidIkRlVc6iTnChJOPAzAkKEUTnmJxuJvR6wCMQ3hHfQnMBE2OwYASwrBEcgieZ22tY9nUypXf1sA35VzThTJaWLUulmvlbB3h0nW60a4N0XqoAlSwtl_Q-HYJjXXl2voOhq7fVifgqFAu2PG2j8DL7HYxvZ_Mn-4eptfziU6wjBOlCi0kzwuBC2uI4BhrxLG0qcImTxhiXBCWFFoynpgiTTnWQuXEpMRiRSkdgfON7so3n60NMavKoK1zqrZNGzJCBWcCMSn3ophThPpzgu1HWf-53htDPXqxQbVvQvC2yFa-rJTvMoyy32iyabK4-YvmsYfPtrptXlmzQ_-DoD-G-IkF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1622606760</pqid></control><display><type>article</type><title>Functionalized halloysite multivalent glycocluster as a new drug delivery system</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Massaro, M ; Riela, S ; Lo Meo, P ; Noto, R ; Cavallaro, G ; Milioto, S ; Lazzara, G</creator><creatorcontrib>Massaro, M ; Riela, S ; Lo Meo, P ; Noto, R ; Cavallaro, G ; Milioto, S ; Lazzara, G</creatorcontrib><description>A new design for halloysite nanotube materials was obtained by grafting chemically modified cyclodextrin units onto the nanotube surface. In particular, grafted cyclodextrins were decorated with thiosaccharide pendants, in order to mimic the well-known binding of sugars to proteins and the glyco-cluster effect occurring during cellular recognition events. The obtained materials were characterized by using a combination of varied techniques (FT-IR spectroscopy, thermogravimetric analysis, scanning electron microscopy, dynamic light scattering, turbidimetry), and their potential drug-delivery abilities were tested by studying their interactions with the common naturally occurring anticancer agent curcumin. A suitable model describing the interaction between our materials and curcumin is proposed.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/c4tb01272k</identifier><identifier>PMID: 32261909</identifier><language>eng</language><publisher>England</publisher><subject>Cellular ; Cyclodextrins ; Drug delivery systems ; Grafting ; Jewelry ; Light scattering ; Mathematical models ; Nanostructure</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2014-11, Vol.2 (44), p.7732-7738</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-aafc897bf81fed28711c0719e5a1db460678264fc9674df5571c8ab2d52e1a333</citedby><cites>FETCH-LOGICAL-c419t-aafc897bf81fed28711c0719e5a1db460678264fc9674df5571c8ab2d52e1a333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32261909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Massaro, M</creatorcontrib><creatorcontrib>Riela, S</creatorcontrib><creatorcontrib>Lo Meo, P</creatorcontrib><creatorcontrib>Noto, R</creatorcontrib><creatorcontrib>Cavallaro, G</creatorcontrib><creatorcontrib>Milioto, S</creatorcontrib><creatorcontrib>Lazzara, G</creatorcontrib><title>Functionalized halloysite multivalent glycocluster as a new drug delivery system</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>A new design for halloysite nanotube materials was obtained by grafting chemically modified cyclodextrin units onto the nanotube surface. In particular, grafted cyclodextrins were decorated with thiosaccharide pendants, in order to mimic the well-known binding of sugars to proteins and the glyco-cluster effect occurring during cellular recognition events. The obtained materials were characterized by using a combination of varied techniques (FT-IR spectroscopy, thermogravimetric analysis, scanning electron microscopy, dynamic light scattering, turbidimetry), and their potential drug-delivery abilities were tested by studying their interactions with the common naturally occurring anticancer agent curcumin. A suitable model describing the interaction between our materials and curcumin is proposed.</description><subject>Cellular</subject><subject>Cyclodextrins</subject><subject>Drug delivery systems</subject><subject>Grafting</subject><subject>Jewelry</subject><subject>Light scattering</subject><subject>Mathematical models</subject><subject>Nanostructure</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkctOwzAQRS0EolXphg9AXiKkgh-JH0uoKCAqwaJI7CLHdkrASYrtFIWvJ9DSbWczI83Rnau5AJxidIkRlVc6iTnChJOPAzAkKEUTnmJxuJvR6wCMQ3hHfQnMBE2OwYASwrBEcgieZ22tY9nUypXf1sA35VzThTJaWLUulmvlbB3h0nW60a4N0XqoAlSwtl_Q-HYJjXXl2voOhq7fVifgqFAu2PG2j8DL7HYxvZ_Mn-4eptfziU6wjBOlCi0kzwuBC2uI4BhrxLG0qcImTxhiXBCWFFoynpgiTTnWQuXEpMRiRSkdgfON7so3n60NMavKoK1zqrZNGzJCBWcCMSn3ophThPpzgu1HWf-53htDPXqxQbVvQvC2yFa-rJTvMoyy32iyabK4-YvmsYfPtrptXlmzQ_-DoD-G-IkF</recordid><startdate>20141128</startdate><enddate>20141128</enddate><creator>Massaro, M</creator><creator>Riela, S</creator><creator>Lo Meo, P</creator><creator>Noto, R</creator><creator>Cavallaro, G</creator><creator>Milioto, S</creator><creator>Lazzara, G</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20141128</creationdate><title>Functionalized halloysite multivalent glycocluster as a new drug delivery system</title><author>Massaro, M ; Riela, S ; Lo Meo, P ; Noto, R ; Cavallaro, G ; Milioto, S ; Lazzara, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-aafc897bf81fed28711c0719e5a1db460678264fc9674df5571c8ab2d52e1a333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Cellular</topic><topic>Cyclodextrins</topic><topic>Drug delivery systems</topic><topic>Grafting</topic><topic>Jewelry</topic><topic>Light scattering</topic><topic>Mathematical models</topic><topic>Nanostructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Massaro, M</creatorcontrib><creatorcontrib>Riela, S</creatorcontrib><creatorcontrib>Lo Meo, P</creatorcontrib><creatorcontrib>Noto, R</creatorcontrib><creatorcontrib>Cavallaro, G</creatorcontrib><creatorcontrib>Milioto, S</creatorcontrib><creatorcontrib>Lazzara, G</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Massaro, M</au><au>Riela, S</au><au>Lo Meo, P</au><au>Noto, R</au><au>Cavallaro, G</au><au>Milioto, S</au><au>Lazzara, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functionalized halloysite multivalent glycocluster as a new drug delivery system</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2014-11-28</date><risdate>2014</risdate><volume>2</volume><issue>44</issue><spage>7732</spage><epage>7738</epage><pages>7732-7738</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>A new design for halloysite nanotube materials was obtained by grafting chemically modified cyclodextrin units onto the nanotube surface. In particular, grafted cyclodextrins were decorated with thiosaccharide pendants, in order to mimic the well-known binding of sugars to proteins and the glyco-cluster effect occurring during cellular recognition events. The obtained materials were characterized by using a combination of varied techniques (FT-IR spectroscopy, thermogravimetric analysis, scanning electron microscopy, dynamic light scattering, turbidimetry), and their potential drug-delivery abilities were tested by studying their interactions with the common naturally occurring anticancer agent curcumin. A suitable model describing the interaction between our materials and curcumin is proposed.</abstract><cop>England</cop><pmid>32261909</pmid><doi>10.1039/c4tb01272k</doi><tpages>7</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 2050-750X
ispartof	Journal of materials chemistry. B, Materials for biology and medicine, 2014-11, Vol.2 (44), p.7732-7738
issn	2050-750X 2050-7518
language	eng
recordid	cdi_proquest_miscellaneous_2387680699
source	Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects	Cellular Cyclodextrins Drug delivery systems Grafting Jewelry Light scattering Mathematical models Nanostructure
title	Functionalized halloysite multivalent glycocluster as a new drug delivery system
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T07%3A01%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functionalized%20halloysite%20multivalent%20glycocluster%20as%20a%20new%20drug%20delivery%20system&rft.jtitle=Journal%20of%20materials%20chemistry.%20B,%20Materials%20for%20biology%20and%20medicine&rft.au=Massaro,%20M&rft.date=2014-11-28&rft.volume=2&rft.issue=44&rft.spage=7732&rft.epage=7738&rft.pages=7732-7738&rft.issn=2050-750X&rft.eissn=2050-7518&rft_id=info:doi/10.1039/c4tb01272k&rft_dat=%3Cproquest_cross%3E2387680699%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1622606760&rft_id=info:pmid/32261909&rfr_iscdi=true