Disruption of Glycogen Utilization Markedly Improves the Efficacy of Carboplatin against Preclinical Models of Clear Cell Ovarian Carcinoma

High stage and recurrent ovarian clear cell carcinoma (OCC) are associated with poor prognosis and resistance to chemotherapy. A distinguishing histological feature of OCC is abundant cytoplasmic stores of glucose, in the form of glycogen, that can be mobilized for cellular metabolism. Here, we repo...

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Veröffentlicht in:	Cancers 2020-04, Vol.12 (4), p.869, Article 869
Hauptverfasser:	Khan, Tashbib, He, Yaowu, Kryza, Thomas, Harrington, Brittney S., Gunter, Jennifer H., Sullivan, Mitchell A., Cuda, Tahleesa, Rogers, Rebecca, Davies, Claire M., Broomfield, Amy, Gough, Madeline, Wu, Andy C., McGann, Thomas, Weroha, S. John, Haluska, Paul, Forbes, Josephine M., Armes, Jane E., Barry, Sinead C., Coward, Jermaine I., Jagasia, Nisha, Chetty, Naven, Snell, Cameron E., Lourie, Rohan, Perrin, Lewis C., Hooper, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Animal models Cancer therapies Carboplatin Cell culture Chemotherapy Clinical trials Glucose Glycogen Life Sciences & Biomedicine Medical prognosis Metabolism Oncology Ovarian cancer Ovarian carcinoma Patients Science & Technology Xenografts
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