Biomaterial strategies for controlling stem cell fate via morphogen sequestration
Protein sequestration plays an essential role in maintaining stem cell populations in the native stem cell niche. Both pluripotent and adult stem cells require the sustained presentation of numerous bioactive growth factors and other soluble cues to potentiate cell fate decisions and morphogenic eve...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2016-01, Vol.4 (20), p.3464-3481 |
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| container_end_page | 3481 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Hettiaratchi, M H Guldberg, R E McDevitt, T C |
| description | Protein sequestration plays an essential role in maintaining stem cell populations in the native stem cell niche. Both pluripotent and adult stem cells require the sustained presentation of numerous bioactive growth factors and other soluble cues to potentiate cell fate decisions and morphogenic events. Consequently, methods of natural protein sequestration employed by the stem cell niche present attractive strategies for developing novel protein delivery vehicles and engineering biomimetic stem cell microenvironments that enhance morphogen bioactivity. In this review, we will explore the role of protein sequestration in the native stem cell niche and how it has inspired the design of several classes of materials that exploit natural protein sequestration to effectively maintain stem cell populations and direct stem cell fate. We will also highlight several recent developments in protein sequestering biomaterials, in which material strategies to sequester complex mixtures of endogenously secreted proteins are also being investigated. |
| doi_str_mv | 10.1039/c5tb02575c |
| format | Article |
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Both pluripotent and adult stem cells require the sustained presentation of numerous bioactive growth factors and other soluble cues to potentiate cell fate decisions and morphogenic events. Consequently, methods of natural protein sequestration employed by the stem cell niche present attractive strategies for developing novel protein delivery vehicles and engineering biomimetic stem cell microenvironments that enhance morphogen bioactivity. In this review, we will explore the role of protein sequestration in the native stem cell niche and how it has inspired the design of several classes of materials that exploit natural protein sequestration to effectively maintain stem cell populations and direct stem cell fate. 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| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2016-01, Vol.4 (20), p.3464-3481 |
| issn | 2050-750X 2050-7518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2387652616 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biomaterials Biomedical materials Decisions Populations Proteins Stem cells Strategy Surgical implants |
| title | Biomaterial strategies for controlling stem cell fate via morphogen sequestration |
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