Photoluminescent polyphosphazene nanoparticles for in situ simvastatin delivery for improving the osteocompatibility of BMSCs
Nanomedicines have found promising applications in regulating the biological behaviors of cells because of the cell endocytosis effect. To enhance the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs), which is one of the key issues in relation to bone regeneration, a biode...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2017-12, Vol.5 (47), p.9300-9311 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Huang, Zhao-Hui Wei, Peng-Fei Jin, Le Hu, Xiao-Qing Cai, Qing Yang, Xiao-Ping |
| description | Nanomedicines have found promising applications in regulating the biological behaviors of cells because of the cell endocytosis effect. To enhance the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs), which is one of the key issues in relation to bone regeneration, a biodegradable simvastatin-bearing polyphosphazene prodrug was synthesized and made into nanoparticles (NPs). At the same time, photoluminescent tryptophan ethyl ester and hydrolyzable glycine ethyl ester were introduced as co-substituted side groups onto the polyphosphazene backbone. The resultant polymer, poly(simvastatin-co-ethyl tryptophanato-co-ethyl glycinato)phosphazene (PTGP-SIM), displayed the expected features of photoluminescence, degradability and sustained SIM release. Endocytosis of PTGP-SIM NPs by BMSCs and the location of internalized NPs, were visualized via the inherent photoluminescence features of PTGP-SIM. Thus, simvastatin was released inside the cells directly along with polymer degradation and could play a role in promoting osteogenic differentiation efficiently at quite a low local concentration. From the results, the present study suggested a very promising biomaterial for use as a flexible and functional carrier for bioactive components, which could find wide applications in relation to tissue regeneration. |
| doi_str_mv | 10.1039/c7tb02281f |
| format | Article |
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To enhance the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs), which is one of the key issues in relation to bone regeneration, a biodegradable simvastatin-bearing polyphosphazene prodrug was synthesized and made into nanoparticles (NPs). At the same time, photoluminescent tryptophan ethyl ester and hydrolyzable glycine ethyl ester were introduced as co-substituted side groups onto the polyphosphazene backbone. The resultant polymer, poly(simvastatin-co-ethyl tryptophanato-co-ethyl glycinato)phosphazene (PTGP-SIM), displayed the expected features of photoluminescence, degradability and sustained SIM release. Endocytosis of PTGP-SIM NPs by BMSCs and the location of internalized NPs, were visualized via the inherent photoluminescence features of PTGP-SIM. Thus, simvastatin was released inside the cells directly along with polymer degradation and could play a role in promoting osteogenic differentiation efficiently at quite a low local concentration. From the results, the present study suggested a very promising biomaterial for use as a flexible and functional carrier for bioactive components, which could find wide applications in relation to tissue regeneration.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/c7tb02281f</identifier><identifier>PMID: 32264533</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Biocompatibility ; Biodegradability ; Biodegradation ; Biological effects ; Biomaterials ; Biomedical materials ; Bone growth ; Bone marrow ; Degradability ; Differentiation (biology) ; Endocytosis ; Glycine ; Luminescence ; Mesenchyme ; Nanoparticles ; Phosphazene ; Photoluminescence ; Photons ; Regeneration ; Regeneration (physiology) ; Simvastatin ; Stromal cells ; Tissue engineering ; Tryptophan</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2017-12, Vol.5 (47), p.9300-9311</ispartof><rights>Copyright Royal Society of Chemistry 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-87e40c41f542174d1b2a2ea24560e469d4f7d247ea0739b1a3cb88fa9820bc313</citedby><cites>FETCH-LOGICAL-c315t-87e40c41f542174d1b2a2ea24560e469d4f7d247ea0739b1a3cb88fa9820bc313</cites><orcidid>0000-0001-6618-0321</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32264533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Zhao-Hui</creatorcontrib><creatorcontrib>Wei, Peng-Fei</creatorcontrib><creatorcontrib>Jin, Le</creatorcontrib><creatorcontrib>Hu, Xiao-Qing</creatorcontrib><creatorcontrib>Cai, Qing</creatorcontrib><creatorcontrib>Yang, Xiao-Ping</creatorcontrib><title>Photoluminescent polyphosphazene nanoparticles for in situ simvastatin delivery for improving the osteocompatibility of BMSCs</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>Nanomedicines have found promising applications in regulating the biological behaviors of cells because of the cell endocytosis effect. To enhance the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs), which is one of the key issues in relation to bone regeneration, a biodegradable simvastatin-bearing polyphosphazene prodrug was synthesized and made into nanoparticles (NPs). At the same time, photoluminescent tryptophan ethyl ester and hydrolyzable glycine ethyl ester were introduced as co-substituted side groups onto the polyphosphazene backbone. The resultant polymer, poly(simvastatin-co-ethyl tryptophanato-co-ethyl glycinato)phosphazene (PTGP-SIM), displayed the expected features of photoluminescence, degradability and sustained SIM release. Endocytosis of PTGP-SIM NPs by BMSCs and the location of internalized NPs, were visualized via the inherent photoluminescence features of PTGP-SIM. Thus, simvastatin was released inside the cells directly along with polymer degradation and could play a role in promoting osteogenic differentiation efficiently at quite a low local concentration. From the results, the present study suggested a very promising biomaterial for use as a flexible and functional carrier for bioactive components, which could find wide applications in relation to tissue regeneration.</description><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>Biodegradation</subject><subject>Biological effects</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Bone growth</subject><subject>Bone marrow</subject><subject>Degradability</subject><subject>Differentiation (biology)</subject><subject>Endocytosis</subject><subject>Glycine</subject><subject>Luminescence</subject><subject>Mesenchyme</subject><subject>Nanoparticles</subject><subject>Phosphazene</subject><subject>Photoluminescence</subject><subject>Photons</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Simvastatin</subject><subject>Stromal cells</subject><subject>Tissue engineering</subject><subject>Tryptophan</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpdkd9LHDEQx0NRqqgv_QNKoC8iXJ382E32sR6eLSgKtdC3Jbs724vsJmuSPTjB_920Z31wHmaG4cN3ZvgS8onBVwaiOm9VaoBzzfoP5JBDAQtVML331sPvA3IS4wPk0KzUQn4kB4LzUhZCHJLnu7VPfphH6zC26BKd_LCd1j5Oa_OEDqkzzk8mJNsOGGnvA7WORpvmnMaNicmkPOhwsBsM2x0wTsFvrPtD0xqpjwl968cpg40dbNpS39OLm5_LeEz2ezNEPHmtR-TX6vJ--X1xfXv1Y_ntetEKVqSFViihlawvJGdKdqzhhqPhsigBZVl1slcdlwoNKFE1zIi20bo3lebQZAlxRE53uvmuxxljqkebvx0G49DPseZCq1JqASKjX96hD34OLl9Xc2BQAeRFmTrbUW3wMQbs6ynY0YRtzaD-60u9VPcX_3xZZfjzq-TcjNi9of9dEC_8rYo6</recordid><startdate>20171221</startdate><enddate>20171221</enddate><creator>Huang, Zhao-Hui</creator><creator>Wei, Peng-Fei</creator><creator>Jin, Le</creator><creator>Hu, Xiao-Qing</creator><creator>Cai, Qing</creator><creator>Yang, Xiao-Ping</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6618-0321</orcidid></search><sort><creationdate>20171221</creationdate><title>Photoluminescent polyphosphazene nanoparticles for in situ simvastatin delivery for improving the osteocompatibility of BMSCs</title><author>Huang, Zhao-Hui ; Wei, Peng-Fei ; Jin, Le ; Hu, Xiao-Qing ; Cai, Qing ; Yang, Xiao-Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-87e40c41f542174d1b2a2ea24560e469d4f7d247ea0739b1a3cb88fa9820bc313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biocompatibility</topic><topic>Biodegradability</topic><topic>Biodegradation</topic><topic>Biological effects</topic><topic>Biomaterials</topic><topic>Biomedical materials</topic><topic>Bone growth</topic><topic>Bone marrow</topic><topic>Degradability</topic><topic>Differentiation (biology)</topic><topic>Endocytosis</topic><topic>Glycine</topic><topic>Luminescence</topic><topic>Mesenchyme</topic><topic>Nanoparticles</topic><topic>Phosphazene</topic><topic>Photoluminescence</topic><topic>Photons</topic><topic>Regeneration</topic><topic>Regeneration (physiology)</topic><topic>Simvastatin</topic><topic>Stromal cells</topic><topic>Tissue engineering</topic><topic>Tryptophan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Zhao-Hui</creatorcontrib><creatorcontrib>Wei, Peng-Fei</creatorcontrib><creatorcontrib>Jin, Le</creatorcontrib><creatorcontrib>Hu, Xiao-Qing</creatorcontrib><creatorcontrib>Cai, Qing</creatorcontrib><creatorcontrib>Yang, Xiao-Ping</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Zhao-Hui</au><au>Wei, Peng-Fei</au><au>Jin, Le</au><au>Hu, Xiao-Qing</au><au>Cai, Qing</au><au>Yang, Xiao-Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photoluminescent polyphosphazene nanoparticles for in situ simvastatin delivery for improving the osteocompatibility of BMSCs</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2017-12-21</date><risdate>2017</risdate><volume>5</volume><issue>47</issue><spage>9300</spage><epage>9311</epage><pages>9300-9311</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>Nanomedicines have found promising applications in regulating the biological behaviors of cells because of the cell endocytosis effect. To enhance the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs), which is one of the key issues in relation to bone regeneration, a biodegradable simvastatin-bearing polyphosphazene prodrug was synthesized and made into nanoparticles (NPs). At the same time, photoluminescent tryptophan ethyl ester and hydrolyzable glycine ethyl ester were introduced as co-substituted side groups onto the polyphosphazene backbone. The resultant polymer, poly(simvastatin-co-ethyl tryptophanato-co-ethyl glycinato)phosphazene (PTGP-SIM), displayed the expected features of photoluminescence, degradability and sustained SIM release. Endocytosis of PTGP-SIM NPs by BMSCs and the location of internalized NPs, were visualized via the inherent photoluminescence features of PTGP-SIM. Thus, simvastatin was released inside the cells directly along with polymer degradation and could play a role in promoting osteogenic differentiation efficiently at quite a low local concentration. From the results, the present study suggested a very promising biomaterial for use as a flexible and functional carrier for bioactive components, which could find wide applications in relation to tissue regeneration.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>32264533</pmid><doi>10.1039/c7tb02281f</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6618-0321</orcidid></addata></record> |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Biocompatibility Biodegradability Biodegradation Biological effects Biomaterials Biomedical materials Bone growth Bone marrow Degradability Differentiation (biology) Endocytosis Glycine Luminescence Mesenchyme Nanoparticles Phosphazene Photoluminescence Photons Regeneration Regeneration (physiology) Simvastatin Stromal cells Tissue engineering Tryptophan |
| title | Photoluminescent polyphosphazene nanoparticles for in situ simvastatin delivery for improving the osteocompatibility of BMSCs |
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