Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology
Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer. Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-ter...
Gespeichert in:
| Veröffentlicht in: | Nanomedicine (London, England) England), 2020-04, Vol.15 (10), p.1019-1036 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1036 |
|---|---|
| container_issue | 10 |
| container_start_page | 1019 |
| container_title | Nanomedicine (London, England) |
| container_volume | 15 |
| creator | de Andrade, Laise R Tedesco, Antonio C Primo, Fernando L Farias, Gabriel R da Silva, Jaqueline R Longo, João Pf de Almeida, Marcos C de Souza, Paulo En de Azevedo, Ricardo B Pinheiro, Willie O Lacava, Zulmira Gm |
| description | Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer.
Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed.
The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, the adverse effects were negligible and the response rates for primary mammary tumor control were significantly improved. Tumor progression was slower after NanoALA-PDT treatment, providing longer survival.
NanoALA is a good proactive drug candidate for PDT against cancer potentially applied as adjuvant/neoadjuvant intervention strategy for breast cancer. |
| doi_str_mv | 10.2217/nnm-2019-0458 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2387646680</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2407348221</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-710a375c72aa579a896869737ab33b641df2dc7e254a019d9a208bea41f79c353</originalsourceid><addsrcrecordid>eNp1kUtv1DAURiNERUthyRZZYsMm1K_4wW5UFVppRDdlbTnODZMqsYPtjJR_X6dTWCCx8kPnfrK_U1UfCP5CKZFX3k81xUTXmDfqVXVBJFe10IK9ft6zulFKn1dvU3rEuFGU4DfVOaNUcCnERXV8WKYQkYNxRB3YfECDRyHmQ8hhHhxqI9iUkbPeQURT6GBE7Yp-WB92-91XZJEPx3I3Q0wzuDwcAQWP5m2-W72dSkY-QLTz-pzsXRjDr_VdddbbMcH7l_Wy-vnt5uH6tt7ff7-73u1rxyTJtSTYMtk4Sa1tpLZKCyW0ZNK2jLWCk66nnZNAG25LB522FKsWLCe91I417LL6fMqdY_i9QMpmGtL2WeshLMlQpqTgQihc0E__oI9hib68zlCOJeOq9F2o-kS5GFKK0Js5DpONqyHYbEJMEWI2IWYTUviPL6lLO0H3l_5joAD6BPRLXiIkN0Cp2pxOZWJwg4f_hD8BxT-aLw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2407348221</pqid></control><display><type>article</type><title>Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology</title><source>PubMed Central</source><creator>de Andrade, Laise R ; Tedesco, Antonio C ; Primo, Fernando L ; Farias, Gabriel R ; da Silva, Jaqueline R ; Longo, João Pf ; de Almeida, Marcos C ; de Souza, Paulo En ; de Azevedo, Ricardo B ; Pinheiro, Willie O ; Lacava, Zulmira Gm</creator><creatorcontrib>de Andrade, Laise R ; Tedesco, Antonio C ; Primo, Fernando L ; Farias, Gabriel R ; da Silva, Jaqueline R ; Longo, João Pf ; de Almeida, Marcos C ; de Souza, Paulo En ; de Azevedo, Ricardo B ; Pinheiro, Willie O ; Lacava, Zulmira Gm</creatorcontrib><description>Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer.
Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed.
The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, the adverse effects were negligible and the response rates for primary mammary tumor control were significantly improved. Tumor progression was slower after NanoALA-PDT treatment, providing longer survival.
NanoALA is a good proactive drug candidate for PDT against cancer potentially applied as adjuvant/neoadjuvant intervention strategy for breast cancer.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm-2019-0458</identifier><identifier>PMID: 32264766</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>4T1 cells ; 5-aminolevulinic acid ; Apoptosis ; Breast cancer ; Cancer therapies ; Cell death ; Metastasis ; Nanoemulsions ; Photodynamic therapy ; Physiology ; polymeric nanoemulsion ; Prostate ; Skin ; Software</subject><ispartof>Nanomedicine (London, England), 2020-04, Vol.15 (10), p.1019-1036</ispartof><rights>2020 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Apr 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-710a375c72aa579a896869737ab33b641df2dc7e254a019d9a208bea41f79c353</citedby><cites>FETCH-LOGICAL-c371t-710a375c72aa579a896869737ab33b641df2dc7e254a019d9a208bea41f79c353</cites><orcidid>0000-0003-2390-3539 ; 0000-0002-6017-7057</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32264766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Andrade, Laise R</creatorcontrib><creatorcontrib>Tedesco, Antonio C</creatorcontrib><creatorcontrib>Primo, Fernando L</creatorcontrib><creatorcontrib>Farias, Gabriel R</creatorcontrib><creatorcontrib>da Silva, Jaqueline R</creatorcontrib><creatorcontrib>Longo, João Pf</creatorcontrib><creatorcontrib>de Almeida, Marcos C</creatorcontrib><creatorcontrib>de Souza, Paulo En</creatorcontrib><creatorcontrib>de Azevedo, Ricardo B</creatorcontrib><creatorcontrib>Pinheiro, Willie O</creatorcontrib><creatorcontrib>Lacava, Zulmira Gm</creatorcontrib><title>Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology</title><title>Nanomedicine (London, England)</title><addtitle>Nanomedicine (Lond)</addtitle><description>Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer.
Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed.
The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, the adverse effects were negligible and the response rates for primary mammary tumor control were significantly improved. Tumor progression was slower after NanoALA-PDT treatment, providing longer survival.
NanoALA is a good proactive drug candidate for PDT against cancer potentially applied as adjuvant/neoadjuvant intervention strategy for breast cancer.</description><subject>4T1 cells</subject><subject>5-aminolevulinic acid</subject><subject>Apoptosis</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Cell death</subject><subject>Metastasis</subject><subject>Nanoemulsions</subject><subject>Photodynamic therapy</subject><subject>Physiology</subject><subject>polymeric nanoemulsion</subject><subject>Prostate</subject><subject>Skin</subject><subject>Software</subject><issn>1743-5889</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kUtv1DAURiNERUthyRZZYsMm1K_4wW5UFVppRDdlbTnODZMqsYPtjJR_X6dTWCCx8kPnfrK_U1UfCP5CKZFX3k81xUTXmDfqVXVBJFe10IK9ft6zulFKn1dvU3rEuFGU4DfVOaNUcCnERXV8WKYQkYNxRB3YfECDRyHmQ8hhHhxqI9iUkbPeQURT6GBE7Yp-WB92-91XZJEPx3I3Q0wzuDwcAQWP5m2-W72dSkY-QLTz-pzsXRjDr_VdddbbMcH7l_Wy-vnt5uH6tt7ff7-73u1rxyTJtSTYMtk4Sa1tpLZKCyW0ZNK2jLWCk66nnZNAG25LB522FKsWLCe91I417LL6fMqdY_i9QMpmGtL2WeshLMlQpqTgQihc0E__oI9hib68zlCOJeOq9F2o-kS5GFKK0Js5DpONqyHYbEJMEWI2IWYTUviPL6lLO0H3l_5joAD6BPRLXiIkN0Cp2pxOZWJwg4f_hD8BxT-aLw</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>de Andrade, Laise R</creator><creator>Tedesco, Antonio C</creator><creator>Primo, Fernando L</creator><creator>Farias, Gabriel R</creator><creator>da Silva, Jaqueline R</creator><creator>Longo, João Pf</creator><creator>de Almeida, Marcos C</creator><creator>de Souza, Paulo En</creator><creator>de Azevedo, Ricardo B</creator><creator>Pinheiro, Willie O</creator><creator>Lacava, Zulmira Gm</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2390-3539</orcidid><orcidid>https://orcid.org/0000-0002-6017-7057</orcidid></search><sort><creationdate>20200401</creationdate><title>Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology</title><author>de Andrade, Laise R ; Tedesco, Antonio C ; Primo, Fernando L ; Farias, Gabriel R ; da Silva, Jaqueline R ; Longo, João Pf ; de Almeida, Marcos C ; de Souza, Paulo En ; de Azevedo, Ricardo B ; Pinheiro, Willie O ; Lacava, Zulmira Gm</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-710a375c72aa579a896869737ab33b641df2dc7e254a019d9a208bea41f79c353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>4T1 cells</topic><topic>5-aminolevulinic acid</topic><topic>Apoptosis</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Cell death</topic><topic>Metastasis</topic><topic>Nanoemulsions</topic><topic>Photodynamic therapy</topic><topic>Physiology</topic><topic>polymeric nanoemulsion</topic><topic>Prostate</topic><topic>Skin</topic><topic>Software</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Andrade, Laise R</creatorcontrib><creatorcontrib>Tedesco, Antonio C</creatorcontrib><creatorcontrib>Primo, Fernando L</creatorcontrib><creatorcontrib>Farias, Gabriel R</creatorcontrib><creatorcontrib>da Silva, Jaqueline R</creatorcontrib><creatorcontrib>Longo, João Pf</creatorcontrib><creatorcontrib>de Almeida, Marcos C</creatorcontrib><creatorcontrib>de Souza, Paulo En</creatorcontrib><creatorcontrib>de Azevedo, Ricardo B</creatorcontrib><creatorcontrib>Pinheiro, Willie O</creatorcontrib><creatorcontrib>Lacava, Zulmira Gm</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Nanomedicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Andrade, Laise R</au><au>Tedesco, Antonio C</au><au>Primo, Fernando L</au><au>Farias, Gabriel R</au><au>da Silva, Jaqueline R</au><au>Longo, João Pf</au><au>de Almeida, Marcos C</au><au>de Souza, Paulo En</au><au>de Azevedo, Ricardo B</au><au>Pinheiro, Willie O</au><au>Lacava, Zulmira Gm</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology</atitle><jtitle>Nanomedicine (London, England)</jtitle><addtitle>Nanomedicine (Lond)</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>15</volume><issue>10</issue><spage>1019</spage><epage>1036</epage><pages>1019-1036</pages><issn>1743-5889</issn><eissn>1748-6963</eissn><abstract>Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer.
Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed.
The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, the adverse effects were negligible and the response rates for primary mammary tumor control were significantly improved. Tumor progression was slower after NanoALA-PDT treatment, providing longer survival.
NanoALA is a good proactive drug candidate for PDT against cancer potentially applied as adjuvant/neoadjuvant intervention strategy for breast cancer.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>32264766</pmid><doi>10.2217/nnm-2019-0458</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0003-2390-3539</orcidid><orcidid>https://orcid.org/0000-0002-6017-7057</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1743-5889 |
| ispartof | Nanomedicine (London, England), 2020-04, Vol.15 (10), p.1019-1036 |
| issn | 1743-5889 1748-6963 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2387646680 |
| source | PubMed Central |
| subjects | 4T1 cells 5-aminolevulinic acid Apoptosis Breast cancer Cancer therapies Cell death Metastasis Nanoemulsions Photodynamic therapy Physiology polymeric nanoemulsion Prostate Skin Software |
| title | Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T05%3A46%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tumor%20cell%20death%20in%20orthotopic%20breast%20cancer%20model%20by%20NanoALA:%20a%20novel%20perspective%20on%20photodynamic%20therapy%20in%20oncology&rft.jtitle=Nanomedicine%20(London,%20England)&rft.au=de%20Andrade,%20Laise%20R&rft.date=2020-04-01&rft.volume=15&rft.issue=10&rft.spage=1019&rft.epage=1036&rft.pages=1019-1036&rft.issn=1743-5889&rft.eissn=1748-6963&rft_id=info:doi/10.2217/nnm-2019-0458&rft_dat=%3Cproquest_cross%3E2407348221%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2407348221&rft_id=info:pmid/32264766&rfr_iscdi=true |