A rapid and highly sensitive strain-effect graphene-based bio-sensor for the detection of stroke and cancer bio-markers
Here, we propose a highly sensitive and rapid bio-sensor for the detection of bio-markers for stroke and cancer-related diseases, based on the utilization of the adsorption properties of ruthenium carbonyl (Ru-CO) clusters on monolayer graphene (MG). A fast rate of decarbonylation of Ru-CO to form r...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2018-05, Vol.6 (17), p.2536-2540 |
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| container_issue | 17 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
| container_volume | 6 |
| creator | Lin, Duo Tseng, Chinh-Yu Lim, Qi Feng Tan, Mein Jin Kong, Kien Voon |
| description | Here, we propose a highly sensitive and rapid bio-sensor for the detection of bio-markers for stroke and cancer-related diseases, based on the utilization of the adsorption properties of ruthenium carbonyl (Ru-CO) clusters on monolayer graphene (MG). A fast rate of decarbonylation of Ru-CO to form ruthenium oxide nanoparticles (RuO
NPs) on MG was observed. The quantitative detection of matrix metalloproteinase-2 (MMP-2) (bio-marker for stroke and vascular diseases) was demonstrated by tracking the spectral shift of the characteristic G band of graphene caused by the adsorption of RuO
NPs. A concentration as low as 17 ng mL
of MMP-2 was detected in a simulated clinical serum sample. This effective bio-sensor has the potential to revolutionize the biomedical field in the early detection and possible prevention of stroke and cancer diagnosis. |
| doi_str_mv | 10.1039/c8tb00404h |
| format | Article |
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NPs) on MG was observed. The quantitative detection of matrix metalloproteinase-2 (MMP-2) (bio-marker for stroke and vascular diseases) was demonstrated by tracking the spectral shift of the characteristic G band of graphene caused by the adsorption of RuO
NPs. A concentration as low as 17 ng mL
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NPs) on MG was observed. The quantitative detection of matrix metalloproteinase-2 (MMP-2) (bio-marker for stroke and vascular diseases) was demonstrated by tracking the spectral shift of the characteristic G band of graphene caused by the adsorption of RuO
NPs. A concentration as low as 17 ng mL
of MMP-2 was detected in a simulated clinical serum sample. 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NPs) on MG was observed. The quantitative detection of matrix metalloproteinase-2 (MMP-2) (bio-marker for stroke and vascular diseases) was demonstrated by tracking the spectral shift of the characteristic G band of graphene caused by the adsorption of RuO
NPs. A concentration as low as 17 ng mL
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| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2018-05, Vol.6 (17), p.2536-2540 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Adsorption Biomarkers Biosensors Cancer Carbonyls Gelatinase A Graphene Matrix metalloproteinase Metalloproteinase Nanoparticles Ruthenium Ruthenium oxide Sensors Stroke Vascular diseases |
| title | A rapid and highly sensitive strain-effect graphene-based bio-sensor for the detection of stroke and cancer bio-markers |
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