A multifunctional luminogen with aggregation-induced emission characteristics for selective imaging and photodynamic killing of both cancer cells and Gram-positive bacteria
The increasing impact of bacteria on cancer progression and treatments has been witnessed in recent years. Insufficient attention to cancer-related bacteria may lead to distant metastasis, poor therapeutic efficiency and low survival rates for cancers. Exploiting new approaches that enable selective...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2018-06, Vol.6 (23), p.3894-3903 |
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| container_issue | 23 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Kang, Miaomiao Kwok, Ryan T K Wang, Jianguo Zhang, Han Lam, Jacky W Y Li, Ying Zhang, Pengfei Zou, Hang Gu, Xinggui Li, Feng Tang, Ben Zhong |
| description | The increasing impact of bacteria on cancer progression and treatments has been witnessed in recent years. Insufficient attention to cancer-related bacteria may lead to distant metastasis, poor therapeutic efficiency and low survival rates for cancers. Exploiting new approaches that enable selective imaging and effective killing of cancer cells and bacteria are thus of great value for the battle against cancers. Herein, we report an aggregation-induced emission (AIE) luminogen, namely TPPCN, with intense emission and efficient reactive oxygen species production for fluorescence imaging and killing cancer cells and Gram-positive bacteria. This work not only demonstrates the potential of AIE luminogens in comprehensive cancer treatments but also stimulates the enthusiasm of scientists to design more multifunctional AIE systems for both cancer and bacteria theranostics. |
| doi_str_mv | 10.1039/c8tb00572a |
| format | Article |
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Insufficient attention to cancer-related bacteria may lead to distant metastasis, poor therapeutic efficiency and low survival rates for cancers. Exploiting new approaches that enable selective imaging and effective killing of cancer cells and bacteria are thus of great value for the battle against cancers. Herein, we report an aggregation-induced emission (AIE) luminogen, namely TPPCN, with intense emission and efficient reactive oxygen species production for fluorescence imaging and killing cancer cells and Gram-positive bacteria. This work not only demonstrates the potential of AIE luminogens in comprehensive cancer treatments but also stimulates the enthusiasm of scientists to design more multifunctional AIE systems for both cancer and bacteria theranostics.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/c8tb00572a</identifier><identifier>PMID: 32254317</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Agglomeration ; Bacteria ; Cancer ; Emission ; Fluorescence ; Gram-positive bacteria ; Imaging ; Metastases ; Precision medicine ; Reactive oxygen species</subject><ispartof>Journal of materials chemistry. 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| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2018-06, Vol.6 (23), p.3894-3903 |
| issn | 2050-750X 2050-7518 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Agglomeration Bacteria Cancer Emission Fluorescence Gram-positive bacteria Imaging Metastases Precision medicine Reactive oxygen species |
| title | A multifunctional luminogen with aggregation-induced emission characteristics for selective imaging and photodynamic killing of both cancer cells and Gram-positive bacteria |
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