A thiol-ene microfluidic device enabling continuous enzymatic digestion and electrophoretic separation as front-end to mass spectrometric peptide analysis

One of the most attractive aspects of microfluidic chips is their capability of integrating several functional units into one single platform. In particular, enzymatic digestion and chemical separation are important steps in processing samples for many biochemical assays. This study presents the dev...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2020-06, Vol.412 (15), p.3559-3571
Hauptverfasser:	Lu, Nan, Sticker, Drago, Kretschmann, Andreas, Petersen, Nickolaj J., Kutter, Jörg P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis Analytical Chemistry Animals Ascorbic acid Biochemistry Characterization and Evaluation of Materials Chemical separation Chemical synthesis Chemistry Chemistry and Materials Science Click Chemistry Digestion Electrophoresis Electrophoresis, Microchip - instrumentation Enzymes Enzymes, Immobilized - chemistry Equipment Design Fluorescent dyes Fluorescent indicators Food Science Lab-On-A-Chip Devices Laboratory Medicine Mass spectrometry Mass Spectrometry - instrumentation Microfluidic devices Microfluidics Monitoring/Environmental Analysis Paper in Forefront Pepsin Pepsin A - chemistry Peptides Peptides - analysis Peptides - isolation & purification Proteolysis Sample preparation Spectrometry Sulfhydryl Compounds - chemistry Swine Thiols
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