Biodegradable pH-responsive hydrogels for controlled dual-drug release

Dual-drug loaded pH-responsive hydrogels were prepared as a delivery system carrying, as exemplars, both anti-cancer and anti-bacterial agents for pH controlled drug release. The hydrogels were composed of poly(l-lactide)-co-polyethyleneglycol-co-poly(l-lactide) dimethacrylates (with various molecul...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2018-01, Vol.6 (3), p.510-517
Hauptverfasser:	Xu, Liang, Qiu, Linzi, Sheng, Yang, Sun, Yixin, Deng, Linhong, Li, Xinqing, Bradley, Mark, Zhang, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic acid Anticancer properties Antiinfectives and antibacterials Biocompatibility Biodegradability Biodegradable materials Biodegradation Cancer Copolymerization Crosslinking Doxorubicin Drug delivery systems Gels Hydrogels Hydrogen ions Isopropylacrylamide Macromolecules Mechanical properties Oligomers pH effects Poly(L-lactide) Polyethylene glycol
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