Metformin arrests the progression of established kidney disease in the subtotal nephrectomy model of chronic kidney disease

Metformin, an AMP-activated protein kinase (AMPK) activator, has been shown in previous studies to reduce kidney fibrosis in different models of experimental chronic kidney disease (CKD). However, in all of these studies, the administration of metformin was initiated before the establishment of rena...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2020-05, Vol.318 (5), p.F1229-F1236
Hauptverfasser:	Borges, Cynthia M, Fujihara, Clarice Kazue, Malheiros, Denise M A C, de Ávila, Victor Ferreira, Formigari, Guilherme Pedrom, Lopes de Faria, José B
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP AMP-activated protein kinase Animal models Blood glucose Blood pressure Fibrosis Kidney diseases Kinases Metformin Mitochondria Nephrectomy Rodents Surgery
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