Development of Magoh protein‐overexpressing HEK cells for optimized therapeutic protein production

In the pharmaceutical industry, the need for high levels of protein expression in mammalian cells has prompted the search for new strategies, including technologies to obtain cells with improved mechanisms that enhance its transcriptional activity, folding, or protein secretion. Chinese Hamster Ovar...

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Veröffentlicht in:	Biotechnology and applied biochemistry 2021-04, Vol.68 (2), p.230-238
Hauptverfasser:	Mufarrege, Eduardo F., Benizio, Evangelina L., Prieto, Claudio C., Chiappini, Fabricio, Rodriguez, María Celeste, Etcheverrigaray, Marina, Kratje, Ricardo B.
Format:	Artikel
Sprache:	eng
Schlagworte:	cell engineering Gene sequencing HEK cells Immunogenicity Mago protein Mammalian cells Pharmaceutical industry Polysaccharides Protein expression Protein folding Proteins rhEPO therapeutic protein production Transcription
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