Long-Term Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density: a 4-Year Longitudinal Study
Introduction Bone mineral density (BMD) declines in the initial years after bariatric surgery, but long-term skeletal effects are unclear and comparisons between sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are rare. Design and Methods An observational longitudinal study of obese pati...
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| Veröffentlicht in: | Obesity surgery 2020-09, Vol.30 (9), p.3317-3325 |
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| creator | Cadart, O. Degrandi, O. Barnetche, T. Mehsen-Cetre, N. Monsaingeon-Henry, M. Pupier, E. Bosc, L. Collet, D. Gronnier, C. Tremollieres, F. Gatta-Cherifi, Blandine |
| description | Introduction
Bone mineral density (BMD) declines in the initial years after bariatric surgery, but long-term skeletal effects are unclear and comparisons between sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are rare.
Design and Methods
An observational longitudinal study of obese patients undergoing SG or RYGB was performed. Whole-body (WB) BMD, along with BMD of the total hip (TH), femoral neck (FN), and lumbar spine (LS), was measured by dual-energy X-ray absorptiometry (DXA) before surgery and yearly thereafter for 4 years. Calciotropic hormones were also measured.
Results
Forty-seven patients undergoing RYGB surgery and 28 patients undergoing SG were included. Four years after RYGB, BMD declined by 2.8 ± 5.8% in LS, 8.6 ± 5% in FN, 10.9 ± 6.3% in TH, and 4.2 ± 6.2% in WB, relative to baseline. For SG, BMD declined by 8.1 ± 5.5% in FN, 7.7 ± 6% in TH, 2.0 ± 7.2% in LS, and 2.5 ± 6.4% in WB after 4 years, relative to baseline. Vitamin D levels increased with supplementation in both groups. Whereas parathyroid hormone levels increased slightly in the RYGB group, they decreased modestly in the SG group (
P
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| doi_str_mv | 10.1007/s11695-020-04568-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2386289056</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2386289056</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-4cfd8564e22002fc0158426189455c5b6c9ae738485ef368f32d13e5643fa7023</originalsourceid><addsrcrecordid>eNp9kU9rFTEUxYNY7LP6BVxIwE030fyfjDtbaxVeKdi66CqkmZsyZSZ5JjPifHvznKrgoqsknN-555KD0CtG3zJKm3eFMd0qQjklVCptiHiCNqyhpj65eYo2tNWUmJaLQ_S8lHtKOdOcP0OHgnOpJeMbtGxTvCPXkEd8FgL4qeAU8Nc0_yQQyQ0-d2XKvccny86Vgl3s8NUA8ANWpRrSuOAU8UmKgC_6CNkN-CPE0k_Le-ywJDfgMt7H9NPc9bHKV_WyvEAHwQ0FXj6cR-jbp7Pr089ke3n-5fTDlngp2USkD51RWgLndf_gKVNGcs1MK5Xy6lb71kEjjDQKgtAmCN4xAdUhgmsoF0foeJ27y-n7DGWyY188DIOLkOZiuTCam5YqXdE3_6H3ac5140rVTNHU79tTfKV8TqVkCHaX-9HlxTJq98XYtRhbi7G_i7Giml4_jJ5vR-j-Wv40UQGxAqVK8Q7yv-xHxv4CiXWWXQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2426371626</pqid></control><display><type>article</type><title>Long-Term Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density: a 4-Year Longitudinal Study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Cadart, O. ; Degrandi, O. ; Barnetche, T. ; Mehsen-Cetre, N. ; Monsaingeon-Henry, M. ; Pupier, E. ; Bosc, L. ; Collet, D. ; Gronnier, C. ; Tremollieres, F. ; Gatta-Cherifi, Blandine</creator><creatorcontrib>Cadart, O. ; Degrandi, O. ; Barnetche, T. ; Mehsen-Cetre, N. ; Monsaingeon-Henry, M. ; Pupier, E. ; Bosc, L. ; Collet, D. ; Gronnier, C. ; Tremollieres, F. ; Gatta-Cherifi, Blandine</creatorcontrib><description>Introduction
Bone mineral density (BMD) declines in the initial years after bariatric surgery, but long-term skeletal effects are unclear and comparisons between sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are rare.
Design and Methods
An observational longitudinal study of obese patients undergoing SG or RYGB was performed. Whole-body (WB) BMD, along with BMD of the total hip (TH), femoral neck (FN), and lumbar spine (LS), was measured by dual-energy X-ray absorptiometry (DXA) before surgery and yearly thereafter for 4 years. Calciotropic hormones were also measured.
Results
Forty-seven patients undergoing RYGB surgery and 28 patients undergoing SG were included. Four years after RYGB, BMD declined by 2.8 ± 5.8% in LS, 8.6 ± 5% in FN, 10.9 ± 6.3% in TH, and 4.2 ± 6.2% in WB, relative to baseline. For SG, BMD declined by 8.1 ± 5.5% in FN, 7.7 ± 6% in TH, 2.0 ± 7.2% in LS, and 2.5 ± 6.4% in WB after 4 years, relative to baseline. Vitamin D levels increased with supplementation in both groups. Whereas parathyroid hormone levels increased slightly in the RYGB group, they decreased modestly in the SG group (
P
< 0.05 in both groups).
Conclusions
Bone loss after 4 years was comparable between the two procedures, although RYGB was associated with a slightly greater decrease at the TH than SG. Bone health should therefore be monitored after both RYGB and SG.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-020-04568-3</identifier><identifier>PMID: 32246412</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Bone Density ; Gastrectomy ; Gastric Bypass ; Gastrointestinal surgery ; Humans ; Longitudinal Studies ; Medicine ; Medicine & Public Health ; Obesity, Morbid - surgery ; Original Contributions ; Surgery ; Weight Loss</subject><ispartof>Obesity surgery, 2020-09, Vol.30 (9), p.3317-3325</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-4cfd8564e22002fc0158426189455c5b6c9ae738485ef368f32d13e5643fa7023</citedby><cites>FETCH-LOGICAL-c441t-4cfd8564e22002fc0158426189455c5b6c9ae738485ef368f32d13e5643fa7023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-020-04568-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-020-04568-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32246412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cadart, O.</creatorcontrib><creatorcontrib>Degrandi, O.</creatorcontrib><creatorcontrib>Barnetche, T.</creatorcontrib><creatorcontrib>Mehsen-Cetre, N.</creatorcontrib><creatorcontrib>Monsaingeon-Henry, M.</creatorcontrib><creatorcontrib>Pupier, E.</creatorcontrib><creatorcontrib>Bosc, L.</creatorcontrib><creatorcontrib>Collet, D.</creatorcontrib><creatorcontrib>Gronnier, C.</creatorcontrib><creatorcontrib>Tremollieres, F.</creatorcontrib><creatorcontrib>Gatta-Cherifi, Blandine</creatorcontrib><title>Long-Term Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density: a 4-Year Longitudinal Study</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Introduction
Bone mineral density (BMD) declines in the initial years after bariatric surgery, but long-term skeletal effects are unclear and comparisons between sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are rare.
Design and Methods
An observational longitudinal study of obese patients undergoing SG or RYGB was performed. Whole-body (WB) BMD, along with BMD of the total hip (TH), femoral neck (FN), and lumbar spine (LS), was measured by dual-energy X-ray absorptiometry (DXA) before surgery and yearly thereafter for 4 years. Calciotropic hormones were also measured.
Results
Forty-seven patients undergoing RYGB surgery and 28 patients undergoing SG were included. Four years after RYGB, BMD declined by 2.8 ± 5.8% in LS, 8.6 ± 5% in FN, 10.9 ± 6.3% in TH, and 4.2 ± 6.2% in WB, relative to baseline. For SG, BMD declined by 8.1 ± 5.5% in FN, 7.7 ± 6% in TH, 2.0 ± 7.2% in LS, and 2.5 ± 6.4% in WB after 4 years, relative to baseline. Vitamin D levels increased with supplementation in both groups. Whereas parathyroid hormone levels increased slightly in the RYGB group, they decreased modestly in the SG group (
P
< 0.05 in both groups).
Conclusions
Bone loss after 4 years was comparable between the two procedures, although RYGB was associated with a slightly greater decrease at the TH than SG. Bone health should therefore be monitored after both RYGB and SG.</description><subject>Bone Density</subject><subject>Gastrectomy</subject><subject>Gastric Bypass</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obesity, Morbid - surgery</subject><subject>Original Contributions</subject><subject>Surgery</subject><subject>Weight Loss</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU9rFTEUxYNY7LP6BVxIwE030fyfjDtbaxVeKdi66CqkmZsyZSZ5JjPifHvznKrgoqsknN-555KD0CtG3zJKm3eFMd0qQjklVCptiHiCNqyhpj65eYo2tNWUmJaLQ_S8lHtKOdOcP0OHgnOpJeMbtGxTvCPXkEd8FgL4qeAU8Nc0_yQQyQ0-d2XKvccny86Vgl3s8NUA8ANWpRrSuOAU8UmKgC_6CNkN-CPE0k_Le-ywJDfgMt7H9NPc9bHKV_WyvEAHwQ0FXj6cR-jbp7Pr089ke3n-5fTDlngp2USkD51RWgLndf_gKVNGcs1MK5Xy6lb71kEjjDQKgtAmCN4xAdUhgmsoF0foeJ27y-n7DGWyY188DIOLkOZiuTCam5YqXdE3_6H3ac5140rVTNHU79tTfKV8TqVkCHaX-9HlxTJq98XYtRhbi7G_i7Giml4_jJ5vR-j-Wv40UQGxAqVK8Q7yv-xHxv4CiXWWXQ</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Cadart, O.</creator><creator>Degrandi, O.</creator><creator>Barnetche, T.</creator><creator>Mehsen-Cetre, N.</creator><creator>Monsaingeon-Henry, M.</creator><creator>Pupier, E.</creator><creator>Bosc, L.</creator><creator>Collet, D.</creator><creator>Gronnier, C.</creator><creator>Tremollieres, F.</creator><creator>Gatta-Cherifi, Blandine</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200901</creationdate><title>Long-Term Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density: a 4-Year Longitudinal Study</title><author>Cadart, O. ; Degrandi, O. ; Barnetche, T. ; Mehsen-Cetre, N. ; Monsaingeon-Henry, M. ; Pupier, E. ; Bosc, L. ; Collet, D. ; Gronnier, C. ; Tremollieres, F. ; Gatta-Cherifi, Blandine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-4cfd8564e22002fc0158426189455c5b6c9ae738485ef368f32d13e5643fa7023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Bone Density</topic><topic>Gastrectomy</topic><topic>Gastric Bypass</topic><topic>Gastrointestinal surgery</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obesity, Morbid - surgery</topic><topic>Original Contributions</topic><topic>Surgery</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cadart, O.</creatorcontrib><creatorcontrib>Degrandi, O.</creatorcontrib><creatorcontrib>Barnetche, T.</creatorcontrib><creatorcontrib>Mehsen-Cetre, N.</creatorcontrib><creatorcontrib>Monsaingeon-Henry, M.</creatorcontrib><creatorcontrib>Pupier, E.</creatorcontrib><creatorcontrib>Bosc, L.</creatorcontrib><creatorcontrib>Collet, D.</creatorcontrib><creatorcontrib>Gronnier, C.</creatorcontrib><creatorcontrib>Tremollieres, F.</creatorcontrib><creatorcontrib>Gatta-Cherifi, Blandine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cadart, O.</au><au>Degrandi, O.</au><au>Barnetche, T.</au><au>Mehsen-Cetre, N.</au><au>Monsaingeon-Henry, M.</au><au>Pupier, E.</au><au>Bosc, L.</au><au>Collet, D.</au><au>Gronnier, C.</au><au>Tremollieres, F.</au><au>Gatta-Cherifi, Blandine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density: a 4-Year Longitudinal Study</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>30</volume><issue>9</issue><spage>3317</spage><epage>3325</epage><pages>3317-3325</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Introduction
Bone mineral density (BMD) declines in the initial years after bariatric surgery, but long-term skeletal effects are unclear and comparisons between sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are rare.
Design and Methods
An observational longitudinal study of obese patients undergoing SG or RYGB was performed. Whole-body (WB) BMD, along with BMD of the total hip (TH), femoral neck (FN), and lumbar spine (LS), was measured by dual-energy X-ray absorptiometry (DXA) before surgery and yearly thereafter for 4 years. Calciotropic hormones were also measured.
Results
Forty-seven patients undergoing RYGB surgery and 28 patients undergoing SG were included. Four years after RYGB, BMD declined by 2.8 ± 5.8% in LS, 8.6 ± 5% in FN, 10.9 ± 6.3% in TH, and 4.2 ± 6.2% in WB, relative to baseline. For SG, BMD declined by 8.1 ± 5.5% in FN, 7.7 ± 6% in TH, 2.0 ± 7.2% in LS, and 2.5 ± 6.4% in WB after 4 years, relative to baseline. Vitamin D levels increased with supplementation in both groups. Whereas parathyroid hormone levels increased slightly in the RYGB group, they decreased modestly in the SG group (
P
< 0.05 in both groups).
Conclusions
Bone loss after 4 years was comparable between the two procedures, although RYGB was associated with a slightly greater decrease at the TH than SG. Bone health should therefore be monitored after both RYGB and SG.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32246412</pmid><doi>10.1007/s11695-020-04568-3</doi><tpages>9</tpages></addata></record> |
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| subjects | Bone Density Gastrectomy Gastric Bypass Gastrointestinal surgery Humans Longitudinal Studies Medicine Medicine & Public Health Obesity, Morbid - surgery Original Contributions Surgery Weight Loss |
| title | Long-Term Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density: a 4-Year Longitudinal Study |
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