S100A9 plays a pivotal role in a mouse model of herpetic neuralgia via TLR4/TNF pathway

•S100A9 is overexpressed in DRGs after HSV-1 infection.•S100A9 positively modulate herpetic neuralgia.•Neutrophils are the main source of S100A9 in DRGs after HSV-1 infection.•S100A9 mediates herpetic neuralgia via the TLR4/TNF pathway. Herpetic neuralgia is a painful condition following herpes zost...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2020-08, Vol.88, p.353-362
Hauptverfasser:	Silva, Cássia R., Melo, Bruno M.S., Silva, Jaqueline R., Lopes, Alexandre H., Pereira, Janaina A., Cecilio, Nerry T., Berlink, Jonilson, Souza, Giovani G., Lucas, Guilherme, Vogl, Thomas, Cunha, Fernando Q., Alves-Filho, José C., Cunha, Thiago M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calgranulin B Disease Models, Animal Herpes Zoster Herpetic neuralgia Mice Neuralgia Neuroglia Neutrophil Pain S100A9 TLR4 Toll-Like Receptor 4 - genetics
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