Impact of GPCR Structures on Drug Discovery

Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with over 370 structures in total bound to different ligands and the receptors in various conformational states. Structure-based drug design has been applied to an increasing number of GPCR targets over the past decade...

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Veröffentlicht in:	Cell 2020-04, Vol.181 (1), p.81-91
Hauptverfasser:	Congreve, Miles, de Graaf, Chris, Swain, Nigel A., Tate, Christopher G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Design Drug Discovery Humans Ligands Molecular Conformation Molecular Structure Receptors, G-Protein-Coupled - chemistry
Online-Zugang:	Volltext
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