Hyodeoxycholic acid (HDCA) suppresses intestinal epithelial cell proliferation through FXR‐PI3K/AKT pathway, accompanied by alteration of bile acids metabolism profiles induced by gut bacteria

Bile acids (BAs) have been implicated in regulation of intestinal epithelial signaling and function. This study aimed to investigate the effects of hyodeoxycholic acid (HDCA) on intestinal epithelial cell proliferation and explore the underlying mechanisms. IPEC‐J2 cells and weaned piglets were trea...

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Veröffentlicht in:	The FASEB journal 2020-05, Vol.34 (5), p.7103-7117
Hauptverfasser:	Song, Min, Yang, Qiang, Zhang, Fenglin, Chen, Lin, Su, Han, Yang, Xiaohua, He, Haiwen, Liu, Fangfang, Zheng, Jisong, Ling, Mingfa, Lai, Xumin, Zhu, Xiaotong, Wang, Lina, Gao, Ping, Shu, Gang, Jiang, Qingyan, Wang, Songbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Acids and Salts - metabolism bile acids metabolism profiles Cell Line Cell Proliferation - drug effects Deoxycholic Acid - administration & dosage Dietary Supplements Female FXR‐PI3K/AKT Gastrointestinal Microbiome - drug effects gut bacteria hyodeoxycholic acid (HDCA) intestinal epithelial cell proliferation Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Male Metabolome - drug effects Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Receptors, Cytoplasmic and Nuclear - metabolism Signal Transduction - drug effects Sus scrofa Swine
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