Effects of Palmaria palmata on lipid metabolism and glycemic control in participants with hypercholesterolemia in a randomized double‐blind placebo‐controlled trial
Background Red algae have been reported to improve lipid and glucose metabolism in rats. We investigated the effects of Palmaria palmata (P. palmata), a red alga from northern Japan, on lipid metabolism and glycemic control in participants with hypercholesterolemia. Methods We conducted an 8‐week, r...
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| Veröffentlicht in: | Phytotherapy research 2020-09, Vol.34 (9), p.2303-2312 |
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| creator | Takase, Takahiro Nakamura, Akinobu Miyoshi, Hideaki Koga, Minori Toyomaki, Atsuhito Kusumi, Ichiro Kino, Rikako Konishi, Yasuyuki Kiso, Yoshinobu Atsumi, Tatsuya |
| description | Background
Red algae have been reported to improve lipid and glucose metabolism in rats. We investigated the effects of Palmaria palmata (P. palmata), a red alga from northern Japan, on lipid metabolism and glycemic control in participants with hypercholesterolemia.
Methods
We conducted an 8‐week, randomized, double‐blind, placebo‐controlled, and parallel‐group comparison trial. The study enrolled Japanese participants with a serum low‐density protein cholesterol (LDL‐C) ≥120 mg/dL. The participants were randomly assigned to take either capsules containing P. palmata (2 g/day) or placebo capsules. The primary endpoint was the change in LDL‐C from baseline to week 8 and the secondary endpoints were the changes in other lipid parameters and glycemic control.
Results
Of the 104 participants completed the study protocol. There were no significant differences in change in LDL‐C, body mass index, waist circumference, or glycemic control between the two groups. However, serum triglyceride showed significantly greater improvement in women in the P. palmata group (−9.0 [−25.0, +5.0]) vs. those in the placebo group (−1.0 [−11.0, +19.0]; p = .03).
Conclusions
The present study did not show that P. palmata had significant effect on serum LDL‐C nor glycemic control, but hypertriglyceridemia could be ameliorated by administration of P. palmata in women. |
| doi_str_mv | 10.1002/ptr.6680 |
| format | Article |
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Red algae have been reported to improve lipid and glucose metabolism in rats. We investigated the effects of Palmaria palmata (P. palmata), a red alga from northern Japan, on lipid metabolism and glycemic control in participants with hypercholesterolemia.
Methods
We conducted an 8‐week, randomized, double‐blind, placebo‐controlled, and parallel‐group comparison trial. The study enrolled Japanese participants with a serum low‐density protein cholesterol (LDL‐C) ≥120 mg/dL. The participants were randomly assigned to take either capsules containing P. palmata (2 g/day) or placebo capsules. The primary endpoint was the change in LDL‐C from baseline to week 8 and the secondary endpoints were the changes in other lipid parameters and glycemic control.
Results
Of the 104 participants completed the study protocol. There were no significant differences in change in LDL‐C, body mass index, waist circumference, or glycemic control between the two groups. However, serum triglyceride showed significantly greater improvement in women in the P. palmata group (−9.0 [−25.0, +5.0]) vs. those in the placebo group (−1.0 [−11.0, +19.0]; p = .03).
Conclusions
The present study did not show that P. palmata had significant effect on serum LDL‐C nor glycemic control, but hypertriglyceridemia could be ameliorated by administration of P. palmata in women.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.6680</identifier><identifier>PMID: 32242987</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Algae ; Body mass ; Body mass index ; Body size ; Cholesterol ; Double-blind studies ; dyslipidemia ; Glucose metabolism ; Hypercholesterolemia ; Hypertriglyceridemia ; Lipid metabolism ; Lipids ; Low density lipoprotein ; Metabolic disorders ; Metabolism ; Palmaria palmata ; red alga ; Triglycerides</subject><ispartof>Phytotherapy research, 2020-09, Vol.34 (9), p.2303-2312</ispartof><rights>2020 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3490-b21491a3920b30a6c66f70ebcf9029294b12031084a70afdea6113ad5c42891b3</citedby><cites>FETCH-LOGICAL-c3490-b21491a3920b30a6c66f70ebcf9029294b12031084a70afdea6113ad5c42891b3</cites><orcidid>0000-0001-6089-2395</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.6680$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.6680$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32242987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takase, Takahiro</creatorcontrib><creatorcontrib>Nakamura, Akinobu</creatorcontrib><creatorcontrib>Miyoshi, Hideaki</creatorcontrib><creatorcontrib>Koga, Minori</creatorcontrib><creatorcontrib>Toyomaki, Atsuhito</creatorcontrib><creatorcontrib>Kusumi, Ichiro</creatorcontrib><creatorcontrib>Kino, Rikako</creatorcontrib><creatorcontrib>Konishi, Yasuyuki</creatorcontrib><creatorcontrib>Kiso, Yoshinobu</creatorcontrib><creatorcontrib>Atsumi, Tatsuya</creatorcontrib><title>Effects of Palmaria palmata on lipid metabolism and glycemic control in participants with hypercholesterolemia in a randomized double‐blind placebo‐controlled trial</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>Background
Red algae have been reported to improve lipid and glucose metabolism in rats. We investigated the effects of Palmaria palmata (P. palmata), a red alga from northern Japan, on lipid metabolism and glycemic control in participants with hypercholesterolemia.
Methods
We conducted an 8‐week, randomized, double‐blind, placebo‐controlled, and parallel‐group comparison trial. The study enrolled Japanese participants with a serum low‐density protein cholesterol (LDL‐C) ≥120 mg/dL. The participants were randomly assigned to take either capsules containing P. palmata (2 g/day) or placebo capsules. The primary endpoint was the change in LDL‐C from baseline to week 8 and the secondary endpoints were the changes in other lipid parameters and glycemic control.
Results
Of the 104 participants completed the study protocol. There were no significant differences in change in LDL‐C, body mass index, waist circumference, or glycemic control between the two groups. However, serum triglyceride showed significantly greater improvement in women in the P. palmata group (−9.0 [−25.0, +5.0]) vs. those in the placebo group (−1.0 [−11.0, +19.0]; p = .03).
Conclusions
The present study did not show that P. palmata had significant effect on serum LDL‐C nor glycemic control, but hypertriglyceridemia could be ameliorated by administration of P. palmata in women.</description><subject>Algae</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Cholesterol</subject><subject>Double-blind studies</subject><subject>dyslipidemia</subject><subject>Glucose metabolism</subject><subject>Hypercholesterolemia</subject><subject>Hypertriglyceridemia</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Palmaria palmata</subject><subject>red alga</subject><subject>Triglycerides</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kdtqFTEUhoModlsFn0AC3ngz7cphZk8updQDFFqkgndhJZNxp2QmYzJD2b3qI_QxfC6fxGy7W0HwKgl86-Nf-Ql5zeCIAfDjaU5HTdPCE7JioFTF6rV4SlagalZJ1n47IC9yvgIAxUE-JweCc8lVu16Rn6d97-ycaezpBYYBk0c67S4z0jjS4Cff0cHNaGLweaA4dvR72Fo3eEttHOcUA_VjmUmzt37Csciu_byhm-3kkt3E4PLsClUmcEciTUUSB3_jOtrFxQT36_bOBF_MU0DrTCzvvToUZi6ZwkvyrMeQ3av9eUi-fji9PPlUnZ1__Hzy_qyyQiqoDGdSMRRlUSMAG9s0_Rqcsb0CrriShnEQDFqJa8C-c9gwJrCrreStYkYcknf33inFH0uJrgefrQsBRxeXrLloG94yBVDQt_-gV3FJY0mnuZSybmqp2r9Cm2LOyfV6Sr7881Yz0Lv2dGlP79or6Ju9cDGD6x7Bh7oKUN0D1z647X9F-uLyyx_hb5r3qJk</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Takase, Takahiro</creator><creator>Nakamura, Akinobu</creator><creator>Miyoshi, Hideaki</creator><creator>Koga, Minori</creator><creator>Toyomaki, Atsuhito</creator><creator>Kusumi, Ichiro</creator><creator>Kino, Rikako</creator><creator>Konishi, Yasuyuki</creator><creator>Kiso, Yoshinobu</creator><creator>Atsumi, Tatsuya</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6089-2395</orcidid></search><sort><creationdate>202009</creationdate><title>Effects of Palmaria palmata on lipid metabolism and glycemic control in participants with hypercholesterolemia in a randomized double‐blind placebo‐controlled trial</title><author>Takase, Takahiro ; Nakamura, Akinobu ; Miyoshi, Hideaki ; Koga, Minori ; Toyomaki, Atsuhito ; Kusumi, Ichiro ; Kino, Rikako ; Konishi, Yasuyuki ; Kiso, Yoshinobu ; Atsumi, Tatsuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3490-b21491a3920b30a6c66f70ebcf9029294b12031084a70afdea6113ad5c42891b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Algae</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Cholesterol</topic><topic>Double-blind studies</topic><topic>dyslipidemia</topic><topic>Glucose metabolism</topic><topic>Hypercholesterolemia</topic><topic>Hypertriglyceridemia</topic><topic>Lipid metabolism</topic><topic>Lipids</topic><topic>Low density lipoprotein</topic><topic>Metabolic disorders</topic><topic>Metabolism</topic><topic>Palmaria palmata</topic><topic>red alga</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takase, Takahiro</creatorcontrib><creatorcontrib>Nakamura, Akinobu</creatorcontrib><creatorcontrib>Miyoshi, Hideaki</creatorcontrib><creatorcontrib>Koga, Minori</creatorcontrib><creatorcontrib>Toyomaki, Atsuhito</creatorcontrib><creatorcontrib>Kusumi, Ichiro</creatorcontrib><creatorcontrib>Kino, Rikako</creatorcontrib><creatorcontrib>Konishi, Yasuyuki</creatorcontrib><creatorcontrib>Kiso, Yoshinobu</creatorcontrib><creatorcontrib>Atsumi, Tatsuya</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takase, Takahiro</au><au>Nakamura, Akinobu</au><au>Miyoshi, Hideaki</au><au>Koga, Minori</au><au>Toyomaki, Atsuhito</au><au>Kusumi, Ichiro</au><au>Kino, Rikako</au><au>Konishi, Yasuyuki</au><au>Kiso, Yoshinobu</au><au>Atsumi, Tatsuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Palmaria palmata on lipid metabolism and glycemic control in participants with hypercholesterolemia in a randomized double‐blind placebo‐controlled trial</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2020-09</date><risdate>2020</risdate><volume>34</volume><issue>9</issue><spage>2303</spage><epage>2312</epage><pages>2303-2312</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Background
Red algae have been reported to improve lipid and glucose metabolism in rats. We investigated the effects of Palmaria palmata (P. palmata), a red alga from northern Japan, on lipid metabolism and glycemic control in participants with hypercholesterolemia.
Methods
We conducted an 8‐week, randomized, double‐blind, placebo‐controlled, and parallel‐group comparison trial. The study enrolled Japanese participants with a serum low‐density protein cholesterol (LDL‐C) ≥120 mg/dL. The participants were randomly assigned to take either capsules containing P. palmata (2 g/day) or placebo capsules. The primary endpoint was the change in LDL‐C from baseline to week 8 and the secondary endpoints were the changes in other lipid parameters and glycemic control.
Results
Of the 104 participants completed the study protocol. There were no significant differences in change in LDL‐C, body mass index, waist circumference, or glycemic control between the two groups. However, serum triglyceride showed significantly greater improvement in women in the P. palmata group (−9.0 [−25.0, +5.0]) vs. those in the placebo group (−1.0 [−11.0, +19.0]; p = .03).
Conclusions
The present study did not show that P. palmata had significant effect on serum LDL‐C nor glycemic control, but hypertriglyceridemia could be ameliorated by administration of P. palmata in women.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>32242987</pmid><doi>10.1002/ptr.6680</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6089-2395</orcidid></addata></record> |
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| ispartof | Phytotherapy research, 2020-09, Vol.34 (9), p.2303-2312 |
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| subjects | Algae Body mass Body mass index Body size Cholesterol Double-blind studies dyslipidemia Glucose metabolism Hypercholesterolemia Hypertriglyceridemia Lipid metabolism Lipids Low density lipoprotein Metabolic disorders Metabolism Palmaria palmata red alga Triglycerides |
| title | Effects of Palmaria palmata on lipid metabolism and glycemic control in participants with hypercholesterolemia in a randomized double‐blind placebo‐controlled trial |
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