Relevance of Fitness to Mortality Risk in Men Receiving Contemporary Medical Care
An inverse association between cardiorespiratory fitness and mortality was robustly demonstrated 3 decades ago. The purpose of this study was to determine whether significant advances in disease prevention, detection, and treatment since that time have modified this association. A total of 47,862 me...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2020-04, Vol.75 (13), p.1538-1547 |
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| container_title | Journal of the American College of Cardiology |
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| creator | Farrell, Stephen W. DeFina, Laura F. Radford, Nina B. Leonard, David Barlow, Carolyn E. Pavlovic, Andjelka Willis, Benjamin L. Haskell, William L. Lee, I-Min |
| description | An inverse association between cardiorespiratory fitness and mortality was robustly demonstrated 3 decades ago.
The purpose of this study was to determine whether significant advances in disease prevention, detection, and treatment since that time have modified this association.
A total of 47,862 men completed baseline examinations, including a maximal treadmill test. Cohort 1 (n = 24,475) was examined during 1971 to 1991 and followed for mortality through 1992. Cohort 2 (n = 23,387) was examined during 1992 to 2013 with follow-up through 2014. Men were categorized as low fit, moderate fit, or high fit using Cooper Clinic normative data. Hazard ratios (HRs) for all-cause, cardiovascular disease, and cancer mortality were determined across fitness categories in the 2 cohorts.
A significant inverse trend between fitness categories and all-cause (HR: 1.0, 0.60, and 0.53 in cohort 1 and HR: 1.0, 0.76, and 0.52 in cohort 2) and cardiovascular disease mortality (HR: 1.0, 0.55, and 0.43 in cohort 1 and HR: 1.0, 0.84, and 0.52 in cohort 2) was observed (p trend |
| doi_str_mv | 10.1016/j.jacc.2020.01.049 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2386281824</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0735109720305283</els_id><sourcerecordid>2386281824</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-8d34846c2f3ea4faf64ef9ac6168a1fc872f50a0fc61cccff048f1a2d707941b3</originalsourceid><addsrcrecordid>eNp9kM9O4zAQh60VaCnsvgAH5COXhPGfOI60F1RtFyQqpAJnyzhj5JLGxU4r8TY8C09GqrIcOY00-n4_zXyEnDIoGTB1sSyX1rmSA4cSWAmy-UEmrKp0IaqmPiATqEVVMGjqI3Kc8xIAlGbNT3IkOJdMqGZC7hbY4db2Dmn0dBaGHnOmQ6TzmAbbheGVLkJ-pqF_f5tjTxfoMGxD_0SnsR9wtY7Jplc6xzY4272_TW3CX-TQ2y7j7895Qh5mf--nV8XN7b_r6eVN4USlhkK3QmqpHPcCrfTWK4m-sU4xpS3zTtfcV2DBjxvnnPcgtWeWtzXUjWSP4oSc73vXKb5sMA9mFbLDrrM9xk02XGjFNdNcjijfoy7FnBN6s05hNV5uGJidTLM0O5lmJ9MAM6PMMXT22b95XGH7FflvbwT-7AEcv9wGTCa7gKPLNiR0g2lj-K7_AzRHh2A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2386281824</pqid></control><display><type>article</type><title>Relevance of Fitness to Mortality Risk in Men Receiving Contemporary Medical Care</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>ScienceDirect Journals (5 years ago - present)</source><source>Alma/SFX Local Collection</source><creator>Farrell, Stephen W. ; DeFina, Laura F. ; Radford, Nina B. ; Leonard, David ; Barlow, Carolyn E. ; Pavlovic, Andjelka ; Willis, Benjamin L. ; Haskell, William L. ; Lee, I-Min</creator><creatorcontrib>Farrell, Stephen W. ; DeFina, Laura F. ; Radford, Nina B. ; Leonard, David ; Barlow, Carolyn E. ; Pavlovic, Andjelka ; Willis, Benjamin L. ; Haskell, William L. ; Lee, I-Min</creatorcontrib><description>An inverse association between cardiorespiratory fitness and mortality was robustly demonstrated 3 decades ago.
The purpose of this study was to determine whether significant advances in disease prevention, detection, and treatment since that time have modified this association.
A total of 47,862 men completed baseline examinations, including a maximal treadmill test. Cohort 1 (n = 24,475) was examined during 1971 to 1991 and followed for mortality through 1992. Cohort 2 (n = 23,387) was examined during 1992 to 2013 with follow-up through 2014. Men were categorized as low fit, moderate fit, or high fit using Cooper Clinic normative data. Hazard ratios (HRs) for all-cause, cardiovascular disease, and cancer mortality were determined across fitness categories in the 2 cohorts.
A significant inverse trend between fitness categories and all-cause (HR: 1.0, 0.60, and 0.53 in cohort 1 and HR: 1.0, 0.76, and 0.52 in cohort 2) and cardiovascular disease mortality (HR: 1.0, 0.55, and 0.43 in cohort 1 and HR: 1.0, 0.84, and 0.52 in cohort 2) was observed (p trend <0.001 for all). The trend across fitness categories and cancer mortality was significant for cohort 1 (HR: 1.0, 0.62, and 0.48; p < 0.001), but not for cohort 2 (HR: 1.0, 1.08, and 0.74; p = 0.19). HRs for all-cause mortality were 0.86 (95% confidence interval: 0.82 to 0.90) and 0.87 (95% confidence interval: 0.83 to 0.91) per 1-MET increment in fitness for cohorts 1 and 2, respectively (p < 0.001 for both). Similar values were seen for cardiovascular disease and cancer mortality.
Despite significant advances in disease prevention, detection, and treatment since fitness was first shown to be associated with mortality, the inverse association between fitness and mortality remains consistent in a contemporary cohort of men.
[Display omitted]</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2020.01.049</identifier><identifier>PMID: 32241369</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Cardiorespiratory Fitness ; exercise testing ; Follow-Up Studies ; Humans ; Male ; Mass Screening ; Middle Aged ; Mortality ; Preventive Medicine</subject><ispartof>Journal of the American College of Cardiology, 2020-04, Vol.75 (13), p.1538-1547</ispartof><rights>2020 American College of Cardiology Foundation</rights><rights>Copyright © 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-8d34846c2f3ea4faf64ef9ac6168a1fc872f50a0fc61cccff048f1a2d707941b3</citedby><cites>FETCH-LOGICAL-c356t-8d34846c2f3ea4faf64ef9ac6168a1fc872f50a0fc61cccff048f1a2d707941b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jacc.2020.01.049$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32241369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farrell, Stephen W.</creatorcontrib><creatorcontrib>DeFina, Laura F.</creatorcontrib><creatorcontrib>Radford, Nina B.</creatorcontrib><creatorcontrib>Leonard, David</creatorcontrib><creatorcontrib>Barlow, Carolyn E.</creatorcontrib><creatorcontrib>Pavlovic, Andjelka</creatorcontrib><creatorcontrib>Willis, Benjamin L.</creatorcontrib><creatorcontrib>Haskell, William L.</creatorcontrib><creatorcontrib>Lee, I-Min</creatorcontrib><title>Relevance of Fitness to Mortality Risk in Men Receiving Contemporary Medical Care</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>An inverse association between cardiorespiratory fitness and mortality was robustly demonstrated 3 decades ago.
The purpose of this study was to determine whether significant advances in disease prevention, detection, and treatment since that time have modified this association.
A total of 47,862 men completed baseline examinations, including a maximal treadmill test. Cohort 1 (n = 24,475) was examined during 1971 to 1991 and followed for mortality through 1992. Cohort 2 (n = 23,387) was examined during 1992 to 2013 with follow-up through 2014. Men were categorized as low fit, moderate fit, or high fit using Cooper Clinic normative data. Hazard ratios (HRs) for all-cause, cardiovascular disease, and cancer mortality were determined across fitness categories in the 2 cohorts.
A significant inverse trend between fitness categories and all-cause (HR: 1.0, 0.60, and 0.53 in cohort 1 and HR: 1.0, 0.76, and 0.52 in cohort 2) and cardiovascular disease mortality (HR: 1.0, 0.55, and 0.43 in cohort 1 and HR: 1.0, 0.84, and 0.52 in cohort 2) was observed (p trend <0.001 for all). The trend across fitness categories and cancer mortality was significant for cohort 1 (HR: 1.0, 0.62, and 0.48; p < 0.001), but not for cohort 2 (HR: 1.0, 1.08, and 0.74; p = 0.19). HRs for all-cause mortality were 0.86 (95% confidence interval: 0.82 to 0.90) and 0.87 (95% confidence interval: 0.83 to 0.91) per 1-MET increment in fitness for cohorts 1 and 2, respectively (p < 0.001 for both). Similar values were seen for cardiovascular disease and cancer mortality.
Despite significant advances in disease prevention, detection, and treatment since fitness was first shown to be associated with mortality, the inverse association between fitness and mortality remains consistent in a contemporary cohort of men.
[Display omitted]</description><subject>Adult</subject><subject>Cardiorespiratory Fitness</subject><subject>exercise testing</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Preventive Medicine</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9O4zAQh60VaCnsvgAH5COXhPGfOI60F1RtFyQqpAJnyzhj5JLGxU4r8TY8C09GqrIcOY00-n4_zXyEnDIoGTB1sSyX1rmSA4cSWAmy-UEmrKp0IaqmPiATqEVVMGjqI3Kc8xIAlGbNT3IkOJdMqGZC7hbY4db2Dmn0dBaGHnOmQ6TzmAbbheGVLkJ-pqF_f5tjTxfoMGxD_0SnsR9wtY7Jplc6xzY4272_TW3CX-TQ2y7j7895Qh5mf--nV8XN7b_r6eVN4USlhkK3QmqpHPcCrfTWK4m-sU4xpS3zTtfcV2DBjxvnnPcgtWeWtzXUjWSP4oSc73vXKb5sMA9mFbLDrrM9xk02XGjFNdNcjijfoy7FnBN6s05hNV5uGJidTLM0O5lmJ9MAM6PMMXT22b95XGH7FflvbwT-7AEcv9wGTCa7gKPLNiR0g2lj-K7_AzRHh2A</recordid><startdate>20200407</startdate><enddate>20200407</enddate><creator>Farrell, Stephen W.</creator><creator>DeFina, Laura F.</creator><creator>Radford, Nina B.</creator><creator>Leonard, David</creator><creator>Barlow, Carolyn E.</creator><creator>Pavlovic, Andjelka</creator><creator>Willis, Benjamin L.</creator><creator>Haskell, William L.</creator><creator>Lee, I-Min</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200407</creationdate><title>Relevance of Fitness to Mortality Risk in Men Receiving Contemporary Medical Care</title><author>Farrell, Stephen W. ; DeFina, Laura F. ; Radford, Nina B. ; Leonard, David ; Barlow, Carolyn E. ; Pavlovic, Andjelka ; Willis, Benjamin L. ; Haskell, William L. ; Lee, I-Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-8d34846c2f3ea4faf64ef9ac6168a1fc872f50a0fc61cccff048f1a2d707941b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Cardiorespiratory Fitness</topic><topic>exercise testing</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Mass Screening</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Preventive Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farrell, Stephen W.</creatorcontrib><creatorcontrib>DeFina, Laura F.</creatorcontrib><creatorcontrib>Radford, Nina B.</creatorcontrib><creatorcontrib>Leonard, David</creatorcontrib><creatorcontrib>Barlow, Carolyn E.</creatorcontrib><creatorcontrib>Pavlovic, Andjelka</creatorcontrib><creatorcontrib>Willis, Benjamin L.</creatorcontrib><creatorcontrib>Haskell, William L.</creatorcontrib><creatorcontrib>Lee, I-Min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farrell, Stephen W.</au><au>DeFina, Laura F.</au><au>Radford, Nina B.</au><au>Leonard, David</au><au>Barlow, Carolyn E.</au><au>Pavlovic, Andjelka</au><au>Willis, Benjamin L.</au><au>Haskell, William L.</au><au>Lee, I-Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relevance of Fitness to Mortality Risk in Men Receiving Contemporary Medical Care</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2020-04-07</date><risdate>2020</risdate><volume>75</volume><issue>13</issue><spage>1538</spage><epage>1547</epage><pages>1538-1547</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><abstract>An inverse association between cardiorespiratory fitness and mortality was robustly demonstrated 3 decades ago.
The purpose of this study was to determine whether significant advances in disease prevention, detection, and treatment since that time have modified this association.
A total of 47,862 men completed baseline examinations, including a maximal treadmill test. Cohort 1 (n = 24,475) was examined during 1971 to 1991 and followed for mortality through 1992. Cohort 2 (n = 23,387) was examined during 1992 to 2013 with follow-up through 2014. Men were categorized as low fit, moderate fit, or high fit using Cooper Clinic normative data. Hazard ratios (HRs) for all-cause, cardiovascular disease, and cancer mortality were determined across fitness categories in the 2 cohorts.
A significant inverse trend between fitness categories and all-cause (HR: 1.0, 0.60, and 0.53 in cohort 1 and HR: 1.0, 0.76, and 0.52 in cohort 2) and cardiovascular disease mortality (HR: 1.0, 0.55, and 0.43 in cohort 1 and HR: 1.0, 0.84, and 0.52 in cohort 2) was observed (p trend <0.001 for all). The trend across fitness categories and cancer mortality was significant for cohort 1 (HR: 1.0, 0.62, and 0.48; p < 0.001), but not for cohort 2 (HR: 1.0, 1.08, and 0.74; p = 0.19). HRs for all-cause mortality were 0.86 (95% confidence interval: 0.82 to 0.90) and 0.87 (95% confidence interval: 0.83 to 0.91) per 1-MET increment in fitness for cohorts 1 and 2, respectively (p < 0.001 for both). Similar values were seen for cardiovascular disease and cancer mortality.
Despite significant advances in disease prevention, detection, and treatment since fitness was first shown to be associated with mortality, the inverse association between fitness and mortality remains consistent in a contemporary cohort of men.
[Display omitted]</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32241369</pmid><doi>10.1016/j.jacc.2020.01.049</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Adult Cardiorespiratory Fitness exercise testing Follow-Up Studies Humans Male Mass Screening Middle Aged Mortality Preventive Medicine |
| title | Relevance of Fitness to Mortality Risk in Men Receiving Contemporary Medical Care |
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