Immobilized enzyme reactors based on nucleoside phosphorylases and 2′-deoxyribosyltransferase for the in-flow synthesis of pharmaceutically relevant nucleoside analogues

[Display omitted] •An in-flow enzymatic system based on immobilized NPs and NDT was developed.•LrNDT and CpUP/AhPNP were immobilized on monolithic silica columns.•The two immobilized enzyme reactors (IMERs) catalyzed continuous reactions in flow.•Pure nucleoside analogues were synthesized in suitabl...

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Veröffentlicht in:	Bioresource technology 2020-07, Vol.307, p.123258-123258, Article 123258
Hauptverfasser:	Rinaldi, Francesca, Fernández-Lucas, Jesús, de la Fuente, Diego, Zheng, Changping, Bavaro, Teodora, Peters, Benjamin, Massolini, Gabriella, Annunziata, Francesca, Conti, Paola, de la Mata, Isabel, Terreni, Marco, Calleri, Enrica
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Enzymes, Immobilized Immobilized enzyme reactors Nucleoside 2′-deoxyribosyltransferases Nucleoside analogues Nucleoside phosphorylases Nucleosides Pentosyltransferases Purine-Nucleoside Phosphorylase
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