Letting the GENIE Out of Its Bottle: Examining the Potential of Real-World Clinicogenomic Data

In this issue, Smyth and colleagues investigate the natural history of -mutant metastatic breast cancer using the AACR Project GENIE, a novel research platform comprised of real-world, clinicogenomic data. A rare subset of tumors, -mutant breast cancers demonstrated similar clinical and demographic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer discovery 2020-04, Vol.10 (4), p.490-491
Hauptverfasser:	Castellanos, Emily, Baxi, Shrujal S
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - drug therapy Breast Neoplasms - genetics Humans Registries
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	491
container_issue	4
container_start_page	490
container_title	Cancer discovery
container_volume	10
creator	Castellanos, Emily Baxi, Shrujal S
description	In this issue, Smyth and colleagues investigate the natural history of -mutant metastatic breast cancer using the AACR Project GENIE, a novel research platform comprised of real-world, clinicogenomic data. A rare subset of tumors, -mutant breast cancers demonstrated similar clinical and demographic characteristics and overall survival as -wild-type tumors, but a longer duration of therapy on mTOR inhibitors. .
doi_str_mv	10.1158/2159-8290.CD-20-0039
format	Article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2385735800</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2385735800</sourcerecordid><originalsourceid>FETCH-LOGICAL-c237t-61583dc8c5c748a021dbaf86dbc4d37ef585cad5127f5951cfc49e0d29a183eb3</originalsourceid><addsrcrecordid>eNo9kF9LwzAUxYMobsx9A5E8-tKZP82a-qZdnYPhRBTfDGmSzkrazCYF_fa2zO2-3MvlnHs5PwAuMZphzPgNwSyNOEnRLFtEBEUI0fQEjI_r0-OcxCMw9f4L9RWnMUPJORhRQiinKRuDj7UJoWq2MHwauMyfVjncdAG6Eq6Ch_cuBGtuYf4j66o5yJ5dME2opB1kL0ba6N21VsPM9hrltqZxdaXgQgZ5Ac5Kab2Z_vcJeHvIX7PHaL1ZrrK7daQITUI07zNRrbhiKom5RATrQpZ8rgsVa5qYknGmpGaYJCVLGValilODNEkl5tQUdAKu93d3rfvujA-irrwy1srGuM6LPi5LKOM9pwmI91LVOu9bU4pdW9Wy_RUYiQGuGMiJgaLIFoIgMcDtbVf_H7qiNvpoOqCkf8tzc_k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2385735800</pqid></control><display><type>article</type><title>Letting the GENIE Out of Its Bottle: Examining the Potential of Real-World Clinicogenomic Data</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Castellanos, Emily ; Baxi, Shrujal S</creator><creatorcontrib>Castellanos, Emily ; Baxi, Shrujal S</creatorcontrib><description>In this issue, Smyth and colleagues investigate the natural history of -mutant metastatic breast cancer using the AACR Project GENIE, a novel research platform comprised of real-world, clinicogenomic data. A rare subset of tumors, -mutant breast cancers demonstrated similar clinical and demographic characteristics and overall survival as -wild-type tumors, but a longer duration of therapy on mTOR inhibitors. .</description><identifier>ISSN: 2159-8274</identifier><identifier>EISSN: 2159-8290</identifier><identifier>DOI: 10.1158/2159-8290.CD-20-0039</identifier><identifier>PMID: 32238395</identifier><language>eng</language><publisher>United States</publisher><subject>Breast Neoplasms - drug therapy ; Breast Neoplasms - genetics ; Humans ; Registries</subject><ispartof>Cancer discovery, 2020-04, Vol.10 (4), p.490-491</ispartof><rights>2020 American Association for Cancer Research.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c237t-61583dc8c5c748a021dbaf86dbc4d37ef585cad5127f5951cfc49e0d29a183eb3</citedby><cites>FETCH-LOGICAL-c237t-61583dc8c5c748a021dbaf86dbc4d37ef585cad5127f5951cfc49e0d29a183eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32238395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castellanos, Emily</creatorcontrib><creatorcontrib>Baxi, Shrujal S</creatorcontrib><title>Letting the GENIE Out of Its Bottle: Examining the Potential of Real-World Clinicogenomic Data</title><title>Cancer discovery</title><addtitle>Cancer Discov</addtitle><description>In this issue, Smyth and colleagues investigate the natural history of -mutant metastatic breast cancer using the AACR Project GENIE, a novel research platform comprised of real-world, clinicogenomic data. A rare subset of tumors, -mutant breast cancers demonstrated similar clinical and demographic characteristics and overall survival as -wild-type tumors, but a longer duration of therapy on mTOR inhibitors. .</description><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - genetics</subject><subject>Humans</subject><subject>Registries</subject><issn>2159-8274</issn><issn>2159-8290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF9LwzAUxYMobsx9A5E8-tKZP82a-qZdnYPhRBTfDGmSzkrazCYF_fa2zO2-3MvlnHs5PwAuMZphzPgNwSyNOEnRLFtEBEUI0fQEjI_r0-OcxCMw9f4L9RWnMUPJORhRQiinKRuDj7UJoWq2MHwauMyfVjncdAG6Eq6Ch_cuBGtuYf4j66o5yJ5dME2opB1kL0ba6N21VsPM9hrltqZxdaXgQgZ5Ac5Kab2Z_vcJeHvIX7PHaL1ZrrK7daQITUI07zNRrbhiKom5RATrQpZ8rgsVa5qYknGmpGaYJCVLGValilODNEkl5tQUdAKu93d3rfvujA-irrwy1srGuM6LPi5LKOM9pwmI91LVOu9bU4pdW9Wy_RUYiQGuGMiJgaLIFoIgMcDtbVf_H7qiNvpoOqCkf8tzc_k</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Castellanos, Emily</creator><creator>Baxi, Shrujal S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202004</creationdate><title>Letting the GENIE Out of Its Bottle: Examining the Potential of Real-World Clinicogenomic Data</title><author>Castellanos, Emily ; Baxi, Shrujal S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c237t-61583dc8c5c748a021dbaf86dbc4d37ef585cad5127f5951cfc49e0d29a183eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - genetics</topic><topic>Humans</topic><topic>Registries</topic><toplevel>online_resources</toplevel><creatorcontrib>Castellanos, Emily</creatorcontrib><creatorcontrib>Baxi, Shrujal S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer discovery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castellanos, Emily</au><au>Baxi, Shrujal S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Letting the GENIE Out of Its Bottle: Examining the Potential of Real-World Clinicogenomic Data</atitle><jtitle>Cancer discovery</jtitle><addtitle>Cancer Discov</addtitle><date>2020-04</date><risdate>2020</risdate><volume>10</volume><issue>4</issue><spage>490</spage><epage>491</epage><pages>490-491</pages><issn>2159-8274</issn><eissn>2159-8290</eissn><abstract>In this issue, Smyth and colleagues investigate the natural history of -mutant metastatic breast cancer using the AACR Project GENIE, a novel research platform comprised of real-world, clinicogenomic data. A rare subset of tumors, -mutant breast cancers demonstrated similar clinical and demographic characteristics and overall survival as -wild-type tumors, but a longer duration of therapy on mTOR inhibitors. .</abstract><cop>United States</cop><pmid>32238395</pmid><doi>10.1158/2159-8290.CD-20-0039</doi><tpages>2</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 2159-8274
ispartof	Cancer discovery, 2020-04, Vol.10 (4), p.490-491
issn	2159-8274 2159-8290
language	eng
recordid	cdi_proquest_miscellaneous_2385735800
source	MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects	Breast Neoplasms - drug therapy Breast Neoplasms - genetics Humans Registries
title	Letting the GENIE Out of Its Bottle: Examining the Potential of Real-World Clinicogenomic Data
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T17%3A16%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Letting%20the%20GENIE%20Out%20of%20Its%20Bottle:%20Examining%20the%20Potential%20of%20Real-World%20Clinicogenomic%20Data&rft.jtitle=Cancer%20discovery&rft.au=Castellanos,%20Emily&rft.date=2020-04&rft.volume=10&rft.issue=4&rft.spage=490&rft.epage=491&rft.pages=490-491&rft.issn=2159-8274&rft.eissn=2159-8290&rft_id=info:doi/10.1158/2159-8290.CD-20-0039&rft_dat=%3Cproquest_cross%3E2385735800%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2385735800&rft_id=info:pmid/32238395&rfr_iscdi=true