Novel electrocardiography parameter for paroxysmal atrial fibrillation in acute ischaemic stroke patients: P wave peak time

IntroductionIn this study, we aimed to investigate the usefulness of P wave peak time (PWPT), a novel ECG parameter, in patients who were diagnosed with acute ischaemic stroke (IS) and had paroxysmal atrial fibrillation (PAF) on Holter monitoring.Materials and methodsIn this retrospective cohort stu...

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Veröffentlicht in:Postgraduate medical journal 2020-10, Vol.96 (1140), p.584-588
Hauptverfasser: Öz, Ahmet, Cinar, Tufan, Kızılto Güler, Cansu, Efe, Süleyman Çağan, Emre, Ufuk, Karabağ, Turgut, Ayça, Burak
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container_issue 1140
container_start_page 584
container_title Postgraduate medical journal
container_volume 96
creator Öz, Ahmet
Cinar, Tufan
Kızılto Güler, Cansu
Efe, Süleyman Çağan
Emre, Ufuk
Karabağ, Turgut
Ayça, Burak
description IntroductionIn this study, we aimed to investigate the usefulness of P wave peak time (PWPT), a novel ECG parameter, in patients who were diagnosed with acute ischaemic stroke (IS) and had paroxysmal atrial fibrillation (PAF) on Holter monitoring.Materials and methodsIn this retrospective cohort study, we included 90 consecutive patients with acute IS who were admitted to our hospital between January 2017 and July 2019. PWPT was described as the time from the beginning of the P wave to its peak, and it was measured from leads DII and VI. The PAF diagnosis was confirmed if it was detected on the ECG during palpitation or in rhythm during the Holter recordings.ResultsIn this study, 34 (37.7%) patients with acute IS were diagnosed with PAF. In multivariate analyses, the independent predictors of PAF were age, PWPT in lead VI and PWPT in lead DII (OR: 1.34, 95% CI 1.15 to 1.56; p
doi_str_mv 10.1136/postgradmedj-2020-137540
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PWPT was described as the time from the beginning of the P wave to its peak, and it was measured from leads DII and VI. The PAF diagnosis was confirmed if it was detected on the ECG during palpitation or in rhythm during the Holter recordings.ResultsIn this study, 34 (37.7%) patients with acute IS were diagnosed with PAF. In multivariate analyses, the independent predictors of PAF were age, PWPT in lead VI and PWPT in lead DII (OR: 1.34, 95% CI 1.15 to 1.56; p&lt;0.001). A receiver operating curve analysis demonstrated that area under the curve values for PWPT in lead DII for PAF were 0.88 (95% CI 0.81 to 0.95, p&lt;0.001). The cut-off value for PWPT in lead DII in predicting PAF was 68.5 ms with a sensitivity of 82.4% and a specificity of 75.0%.ConclusionTo the best of our knowledge, this is the first study to demonstrate a significant relationship between PWPT in lead DII and PAF among patients with acute IS.</description><identifier>ISSN: 0032-5473</identifier><identifier>EISSN: 1469-0756</identifier><identifier>DOI: 10.1136/postgradmedj-2020-137540</identifier><identifier>PMID: 32234836</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Blood ; Cardiac arrhythmia ; Cardiovascular disease ; Carotid arteries ; Coronary vessels ; Diabetes ; Electrocardiography ; Hospitals ; Hypertension ; Laboratories ; Morphology ; Software ; Stroke ; Variables</subject><ispartof>Postgraduate medical journal, 2020-10, Vol.96 (1140), p.584-588</ispartof><rights>Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2020 Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b387t-2c6df2e69d8ef05ba24dab1ac6ab1dd11216714476a610958c85cfc54899e2f03</citedby><cites>FETCH-LOGICAL-b387t-2c6df2e69d8ef05ba24dab1ac6ab1dd11216714476a610958c85cfc54899e2f03</cites><orcidid>0000-0003-0268-9641 ; 0000-0001-8188-5020</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32234836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Öz, Ahmet</creatorcontrib><creatorcontrib>Cinar, Tufan</creatorcontrib><creatorcontrib>Kızılto Güler, Cansu</creatorcontrib><creatorcontrib>Efe, Süleyman Çağan</creatorcontrib><creatorcontrib>Emre, Ufuk</creatorcontrib><creatorcontrib>Karabağ, Turgut</creatorcontrib><creatorcontrib>Ayça, Burak</creatorcontrib><title>Novel electrocardiography parameter for paroxysmal atrial fibrillation in acute ischaemic stroke patients: P wave peak time</title><title>Postgraduate medical journal</title><addtitle>Postgrad Med J</addtitle><description>IntroductionIn this study, we aimed to investigate the usefulness of P wave peak time (PWPT), a novel ECG parameter, in patients who were diagnosed with acute ischaemic stroke (IS) and had paroxysmal atrial fibrillation (PAF) on Holter monitoring.Materials and methodsIn this retrospective cohort study, we included 90 consecutive patients with acute IS who were admitted to our hospital between January 2017 and July 2019. PWPT was described as the time from the beginning of the P wave to its peak, and it was measured from leads DII and VI. The PAF diagnosis was confirmed if it was detected on the ECG during palpitation or in rhythm during the Holter recordings.ResultsIn this study, 34 (37.7%) patients with acute IS were diagnosed with PAF. In multivariate analyses, the independent predictors of PAF were age, PWPT in lead VI and PWPT in lead DII (OR: 1.34, 95% CI 1.15 to 1.56; p&lt;0.001). A receiver operating curve analysis demonstrated that area under the curve values for PWPT in lead DII for PAF were 0.88 (95% CI 0.81 to 0.95, p&lt;0.001). The cut-off value for PWPT in lead DII in predicting PAF was 68.5 ms with a sensitivity of 82.4% and a specificity of 75.0%.ConclusionTo the best of our knowledge, this is the first study to demonstrate a significant relationship between PWPT in lead DII and PAF among patients with acute IS.</description><subject>Blood</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular disease</subject><subject>Carotid arteries</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Electrocardiography</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Laboratories</subject><subject>Morphology</subject><subject>Software</subject><subject>Stroke</subject><subject>Variables</subject><issn>0032-5473</issn><issn>1469-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc1u1DAUhS0EokPhFZClbtiE-i-Oww5VLVSqgAWsrRvnhnqaxMF22o54eTyaFlWs2PjK9nfOPdIhhHL2nnOpT5eQ8s8I_YT9thJMsIrLplbsGdlwpduKNbV-TjaMSVHVqpFH5FVKW8YKpfhLciSFkMpIvSG_v4RbHCmO6HIMDmLvQ3Fernd0gQgTZox0CHF_C_e7NMFIIUdfxuC76McRsg8z9TMFt2akPrlrwMk7morhDRZh9jjn9IF-o3dwWx4Qbmj2E74mLwYYE755mMfkx8X597PP1dXXT5dnH6-qTpomV8LpfhCo297gwOoOhOqh4-B0Ofuec8F1w5VqNGjO2to4U7vB1cq0LYqByWPy7uC7xPBrxZTtVFJiiT5jWJMV0tSNUK3WBT35B92GNc4lnRVKmaZlRu4NzYFyMaQUcbBL9BPEneXM7guyTwuy-4LsoaAiffuwYO3K51_hYyMFkAegm7b_b_sHwq-jDw</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Öz, Ahmet</creator><creator>Cinar, Tufan</creator><creator>Kızılto Güler, Cansu</creator><creator>Efe, Süleyman Çağan</creator><creator>Emre, Ufuk</creator><creator>Karabağ, Turgut</creator><creator>Ayça, Burak</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0268-9641</orcidid><orcidid>https://orcid.org/0000-0001-8188-5020</orcidid></search><sort><creationdate>20201001</creationdate><title>Novel electrocardiography parameter for paroxysmal atrial fibrillation in acute ischaemic stroke patients: P wave peak time</title><author>Öz, Ahmet ; Cinar, Tufan ; Kızılto Güler, Cansu ; Efe, Süleyman Çağan ; Emre, Ufuk ; Karabağ, Turgut ; Ayça, Burak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b387t-2c6df2e69d8ef05ba24dab1ac6ab1dd11216714476a610958c85cfc54899e2f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Blood</topic><topic>Cardiac arrhythmia</topic><topic>Cardiovascular disease</topic><topic>Carotid arteries</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Electrocardiography</topic><topic>Hospitals</topic><topic>Hypertension</topic><topic>Laboratories</topic><topic>Morphology</topic><topic>Software</topic><topic>Stroke</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Öz, Ahmet</creatorcontrib><creatorcontrib>Cinar, Tufan</creatorcontrib><creatorcontrib>Kızılto Güler, Cansu</creatorcontrib><creatorcontrib>Efe, Süleyman Çağan</creatorcontrib><creatorcontrib>Emre, Ufuk</creatorcontrib><creatorcontrib>Karabağ, Turgut</creatorcontrib><creatorcontrib>Ayça, Burak</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; 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Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Postgraduate medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Öz, Ahmet</au><au>Cinar, Tufan</au><au>Kızılto Güler, Cansu</au><au>Efe, Süleyman Çağan</au><au>Emre, Ufuk</au><au>Karabağ, Turgut</au><au>Ayça, Burak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel electrocardiography parameter for paroxysmal atrial fibrillation in acute ischaemic stroke patients: P wave peak time</atitle><jtitle>Postgraduate medical journal</jtitle><addtitle>Postgrad Med J</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>96</volume><issue>1140</issue><spage>584</spage><epage>588</epage><pages>584-588</pages><issn>0032-5473</issn><eissn>1469-0756</eissn><abstract>IntroductionIn this study, we aimed to investigate the usefulness of P wave peak time (PWPT), a novel ECG parameter, in patients who were diagnosed with acute ischaemic stroke (IS) and had paroxysmal atrial fibrillation (PAF) on Holter monitoring.Materials and methodsIn this retrospective cohort study, we included 90 consecutive patients with acute IS who were admitted to our hospital between January 2017 and July 2019. PWPT was described as the time from the beginning of the P wave to its peak, and it was measured from leads DII and VI. The PAF diagnosis was confirmed if it was detected on the ECG during palpitation or in rhythm during the Holter recordings.ResultsIn this study, 34 (37.7%) patients with acute IS were diagnosed with PAF. In multivariate analyses, the independent predictors of PAF were age, PWPT in lead VI and PWPT in lead DII (OR: 1.34, 95% CI 1.15 to 1.56; p&lt;0.001). A receiver operating curve analysis demonstrated that area under the curve values for PWPT in lead DII for PAF were 0.88 (95% CI 0.81 to 0.95, p&lt;0.001). The cut-off value for PWPT in lead DII in predicting PAF was 68.5 ms with a sensitivity of 82.4% and a specificity of 75.0%.ConclusionTo the best of our knowledge, this is the first study to demonstrate a significant relationship between PWPT in lead DII and PAF among patients with acute IS.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>32234836</pmid><doi>10.1136/postgradmedj-2020-137540</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-0268-9641</orcidid><orcidid>https://orcid.org/0000-0001-8188-5020</orcidid></addata></record>
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source Oxford University Press Journals All Titles (1996-Current)
subjects Blood
Cardiac arrhythmia
Cardiovascular disease
Carotid arteries
Coronary vessels
Diabetes
Electrocardiography
Hospitals
Hypertension
Laboratories
Morphology
Software
Stroke
Variables
title Novel electrocardiography parameter for paroxysmal atrial fibrillation in acute ischaemic stroke patients: P wave peak time
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