Adjuvant intraperitoneal ceftriaxone in the treatment of septic peritonitis in horses
BackgroundIntraperitoneal administration of ceftriaxone maintains therapeutic abdominal concentrations for 24 hours in healthy horses. Therefore, it is a possible treatment for septic peritonitis. The aim of this study was to evaluate the efficacy of ceftriaxone as an adjuvant treatment in horses wi...
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| Veröffentlicht in: | Veterinary record 2020-08, Vol.187 (4), p.e29-e29 |
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| creator | Alonso, Juliana de Moura Rosa, Gustavo dos Santos Santos, Bruna Guerra, Simony Ribeiro, Márcio Watanabe, Marcos Jun Alves, A Rodrigues, Celso Takahira, Regina Kiomi Hussni, Carlos Alberto |
| description | BackgroundIntraperitoneal administration of ceftriaxone maintains therapeutic abdominal concentrations for 24 hours in healthy horses. Therefore, it is a possible treatment for septic peritonitis. The aim of this study was to evaluate the efficacy of ceftriaxone as an adjuvant treatment in horses with septic peritonitis.MethodsTwenty-six horses with clinical signs, sonography and/or laboratory findings of septic peritonitis were included. Peritoneal fluid was collected for microbiological culture and in vitro microbial sensitivity profile assessment. Daily intraperitoneal administration of ceftriaxone (25 mg/kg) was initiated with supportive and systemic antimicrobial treatment. The animals were divided into three groups: group 1—gastrointestinal tract injuries and abdominal surgery (excluding perforations/ruptures); group 2—not related to changes in the gastrointestinal tract; group 3—secondary to intestinal rupture and/or faeces contamination.ResultsThe mean success rate of the treatment was 77 per cent (20/26 animals), with success rates of 84.6 per cent in group 1; 87.5 per cent, group 2; and 40 per cent, group 3.ConclusionsThis is the first study to report adjuvant intraperitoneal treatment ceftriaxone for septic peritonitis in horses and indicates that this treatment can successfully treat septic peritonitis in horses. |
| doi_str_mv | 10.1136/vr.105570 |
| format | Article |
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Therefore, it is a possible treatment for septic peritonitis. The aim of this study was to evaluate the efficacy of ceftriaxone as an adjuvant treatment in horses with septic peritonitis.MethodsTwenty-six horses with clinical signs, sonography and/or laboratory findings of septic peritonitis were included. Peritoneal fluid was collected for microbiological culture and in vitro microbial sensitivity profile assessment. Daily intraperitoneal administration of ceftriaxone (25 mg/kg) was initiated with supportive and systemic antimicrobial treatment. The animals were divided into three groups: group 1—gastrointestinal tract injuries and abdominal surgery (excluding perforations/ruptures); group 2—not related to changes in the gastrointestinal tract; group 3—secondary to intestinal rupture and/or faeces contamination.ResultsThe mean success rate of the treatment was 77 per cent (20/26 animals), with success rates of 84.6 per cent in group 1; 87.5 per cent, group 2; and 40 per cent, group 3.ConclusionsThis is the first study to report adjuvant intraperitoneal treatment ceftriaxone for septic peritonitis in horses and indicates that this treatment can successfully treat septic peritonitis in horses.</description><identifier>ISSN: 0042-4900</identifier><identifier>EISSN: 2042-7670</identifier><identifier>DOI: 10.1136/vr.105570</identifier><identifier>PMID: 32234866</identifier><language>eng</language><publisher>England: BMJ Publishing Group Limited</publisher><subject>Abdomen ; Abdominal surgery ; Animals ; Antibiotics ; antimicrobials ; Catheters ; cephalosporins ; horses ; Laboratories ; peritoneum ; Peritonitis ; Ultrasonic imaging ; Veterinary medicine</subject><ispartof>Veterinary record, 2020-08, Vol.187 (4), p.e29-e29</ispartof><rights>British Veterinary Association 2020. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2020 British Veterinary Association</rights><rights>2020 British Veterinary Association 2020. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b3860-8fc208384e9489890c77136a7d8d7ef5d76c3e03e2726ac5c7dfb7193865621d3</citedby><cites>FETCH-LOGICAL-b3860-8fc208384e9489890c77136a7d8d7ef5d76c3e03e2726ac5c7dfb7193865621d3</cites><orcidid>0000-0001-5421-2904 ; 0000-0002-8664-5963</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1136%2Fvr.105570$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1136%2Fvr.105570$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32234866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alonso, Juliana de Moura</creatorcontrib><creatorcontrib>Rosa, Gustavo dos Santos</creatorcontrib><creatorcontrib>Santos, Bruna</creatorcontrib><creatorcontrib>Guerra, Simony</creatorcontrib><creatorcontrib>Ribeiro, Márcio</creatorcontrib><creatorcontrib>Watanabe, Marcos Jun</creatorcontrib><creatorcontrib>Alves, A</creatorcontrib><creatorcontrib>Rodrigues, Celso</creatorcontrib><creatorcontrib>Takahira, Regina Kiomi</creatorcontrib><creatorcontrib>Hussni, Carlos Alberto</creatorcontrib><title>Adjuvant intraperitoneal ceftriaxone in the treatment of septic peritonitis in horses</title><title>Veterinary record</title><addtitle>Vet Rec</addtitle><description>BackgroundIntraperitoneal administration of ceftriaxone maintains therapeutic abdominal concentrations for 24 hours in healthy horses. Therefore, it is a possible treatment for septic peritonitis. The aim of this study was to evaluate the efficacy of ceftriaxone as an adjuvant treatment in horses with septic peritonitis.MethodsTwenty-six horses with clinical signs, sonography and/or laboratory findings of septic peritonitis were included. Peritoneal fluid was collected for microbiological culture and in vitro microbial sensitivity profile assessment. Daily intraperitoneal administration of ceftriaxone (25 mg/kg) was initiated with supportive and systemic antimicrobial treatment. The animals were divided into three groups: group 1—gastrointestinal tract injuries and abdominal surgery (excluding perforations/ruptures); group 2—not related to changes in the gastrointestinal tract; group 3—secondary to intestinal rupture and/or faeces contamination.ResultsThe mean success rate of the treatment was 77 per cent (20/26 animals), with success rates of 84.6 per cent in group 1; 87.5 per cent, group 2; and 40 per cent, group 3.ConclusionsThis is the first study to report adjuvant intraperitoneal treatment ceftriaxone for septic peritonitis in horses and indicates that this treatment can successfully treat septic peritonitis in horses.</description><subject>Abdomen</subject><subject>Abdominal surgery</subject><subject>Animals</subject><subject>Antibiotics</subject><subject>antimicrobials</subject><subject>Catheters</subject><subject>cephalosporins</subject><subject>horses</subject><subject>Laboratories</subject><subject>peritoneum</subject><subject>Peritonitis</subject><subject>Ultrasonic imaging</subject><subject>Veterinary medicine</subject><issn>0042-4900</issn><issn>2042-7670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kEtLAzEUhYMoWh8L_4AM6EIXrXeSmSSzLOILBKGo25Bm7mDKPGqSqfrvTZnqQtBVEs53zr05hBynMElTxi9XbpJCngvYIiMKGR0LLmCbjGB9zwqAPbLv_QKAFjmju2SPUcoyyfmIPE_LRb_SbUhsG5xeorOha1HXicEqOKs_4itqSXjFJDjUocEId1XicRmsSTYOG6xfY6-d8-gPyU6la49Hm_OAPN9cP13djR8eb--vpg_jOZMcxrIyFCSTGRaZLGQBRoj4Hy1KWQqs8lJwwxAYUkG5NrkRZTUXaRHNOadpyQ7I-ZC7dN1bjz6oxnqDda1b7HqvKJO5oFlKs4ie_kIXXe_auJ2KKgeZA4dIXQyUcZ33Diu1dLbR7lOloNZdq5VTQ9eRPdkk9vMGyx_yu9wIsAF4tzV-_p2kXq6fZi-zn9izwTVvFv9M_wLp5JPw</recordid><startdate>20200822</startdate><enddate>20200822</enddate><creator>Alonso, Juliana de Moura</creator><creator>Rosa, Gustavo dos Santos</creator><creator>Santos, Bruna</creator><creator>Guerra, Simony</creator><creator>Ribeiro, Márcio</creator><creator>Watanabe, Marcos Jun</creator><creator>Alves, A</creator><creator>Rodrigues, Celso</creator><creator>Takahira, Regina Kiomi</creator><creator>Hussni, Carlos Alberto</creator><general>BMJ Publishing Group Limited</general><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5421-2904</orcidid><orcidid>https://orcid.org/0000-0002-8664-5963</orcidid></search><sort><creationdate>20200822</creationdate><title>Adjuvant intraperitoneal ceftriaxone in the treatment of septic peritonitis in horses</title><author>Alonso, Juliana de Moura ; Rosa, Gustavo dos Santos ; Santos, Bruna ; Guerra, Simony ; Ribeiro, Márcio ; Watanabe, Marcos Jun ; Alves, A ; Rodrigues, Celso ; Takahira, Regina Kiomi ; Hussni, Carlos Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b3860-8fc208384e9489890c77136a7d8d7ef5d76c3e03e2726ac5c7dfb7193865621d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdomen</topic><topic>Abdominal surgery</topic><topic>Animals</topic><topic>Antibiotics</topic><topic>antimicrobials</topic><topic>Catheters</topic><topic>cephalosporins</topic><topic>horses</topic><topic>Laboratories</topic><topic>peritoneum</topic><topic>Peritonitis</topic><topic>Ultrasonic imaging</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alonso, Juliana de Moura</creatorcontrib><creatorcontrib>Rosa, Gustavo dos Santos</creatorcontrib><creatorcontrib>Santos, Bruna</creatorcontrib><creatorcontrib>Guerra, Simony</creatorcontrib><creatorcontrib>Ribeiro, Márcio</creatorcontrib><creatorcontrib>Watanabe, Marcos Jun</creatorcontrib><creatorcontrib>Alves, A</creatorcontrib><creatorcontrib>Rodrigues, Celso</creatorcontrib><creatorcontrib>Takahira, Regina Kiomi</creatorcontrib><creatorcontrib>Hussni, Carlos Alberto</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary record</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alonso, Juliana de Moura</au><au>Rosa, Gustavo dos Santos</au><au>Santos, Bruna</au><au>Guerra, Simony</au><au>Ribeiro, Márcio</au><au>Watanabe, Marcos Jun</au><au>Alves, A</au><au>Rodrigues, Celso</au><au>Takahira, Regina Kiomi</au><au>Hussni, Carlos Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adjuvant intraperitoneal ceftriaxone in the treatment of septic peritonitis in horses</atitle><jtitle>Veterinary record</jtitle><addtitle>Vet Rec</addtitle><date>2020-08-22</date><risdate>2020</risdate><volume>187</volume><issue>4</issue><spage>e29</spage><epage>e29</epage><pages>e29-e29</pages><issn>0042-4900</issn><eissn>2042-7670</eissn><abstract>BackgroundIntraperitoneal administration of ceftriaxone maintains therapeutic abdominal concentrations for 24 hours in healthy horses. Therefore, it is a possible treatment for septic peritonitis. The aim of this study was to evaluate the efficacy of ceftriaxone as an adjuvant treatment in horses with septic peritonitis.MethodsTwenty-six horses with clinical signs, sonography and/or laboratory findings of septic peritonitis were included. Peritoneal fluid was collected for microbiological culture and in vitro microbial sensitivity profile assessment. Daily intraperitoneal administration of ceftriaxone (25 mg/kg) was initiated with supportive and systemic antimicrobial treatment. The animals were divided into three groups: group 1—gastrointestinal tract injuries and abdominal surgery (excluding perforations/ruptures); group 2—not related to changes in the gastrointestinal tract; group 3—secondary to intestinal rupture and/or faeces contamination.ResultsThe mean success rate of the treatment was 77 per cent (20/26 animals), with success rates of 84.6 per cent in group 1; 87.5 per cent, group 2; and 40 per cent, group 3.ConclusionsThis is the first study to report adjuvant intraperitoneal treatment ceftriaxone for septic peritonitis in horses and indicates that this treatment can successfully treat septic peritonitis in horses.</abstract><cop>England</cop><pub>BMJ Publishing Group Limited</pub><pmid>32234866</pmid><doi>10.1136/vr.105570</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5421-2904</orcidid><orcidid>https://orcid.org/0000-0002-8664-5963</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Abdomen Abdominal surgery Animals Antibiotics antimicrobials Catheters cephalosporins horses Laboratories peritoneum Peritonitis Ultrasonic imaging Veterinary medicine |
| title | Adjuvant intraperitoneal ceftriaxone in the treatment of septic peritonitis in horses |
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