Salivary protein candidates for biomarkers of oral disorders in alcohol and tobacco dependents
Objectives To evaluate the oral condition of alcohol and tobacco dependents and identify salivary protein candidates for biomarkers of oral disorders. Subjects and methods Thirty‐three male volunteers were evaluated for alcohol abuse rehabilitation; nine were selected for proteomic analysis. Intraor...
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| Veröffentlicht in: | Oral diseases 2020-09, Vol.26 (6), p.1200-1208 |
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| creator | Penteado, Carlos Antonio Schaffer Batista, Thiago Beltrami Dias Chaiben, Cassiano Lima Bonacin, Bruna Guedes Ventura, Talita M. O. Dionizio, Aline Couto Souza, Paulo Henrique Buzalaf, Marília Afonso Rabelo Azevedo‐Alanis, Luciana Reis |
| description | Objectives
To evaluate the oral condition of alcohol and tobacco dependents and identify salivary protein candidates for biomarkers of oral disorders.
Subjects and methods
Thirty‐three male volunteers were evaluated for alcohol abuse rehabilitation; nine were selected for proteomic analysis. Intraoral examination was performed, and non‐stimulated saliva was collected. Salivary proteins were extracted and processed for analysis. A list of proteins identified in saliva was generated from the database and manually revised, obtaining the total number of candidate biomarkers for oral disorders.
Results
The mean age (n = 33) was 42.94 ± 8.61 years. Fourteen (42.4%) subjects presented with 23 oral mucosa changes, and 31 (94%) had dental plaque. A total of 282 proteins were found in saliva (n = 9), of which 26 were identified as candidates for biomarkers of oral disorders. After manual review, 21 proteins were selected. The highest number of candidates for biomarkers was associated with carcinoma of head and neck (n = 10), nasopharyngeal carcinoma (n = 6), and periodontal disease (n = 6).
Conclusion
Alcohol and tobacco dependents showed gingival inflammation, and less than half of them showed oral mucosa changes. Twenty‐one protein candidates for biomarkers of oral disorders were identified in saliva. The two major oral disorders in number of candidates for biomarkers were head and neck cancer and periodontal disease. |
| doi_str_mv | 10.1111/odi.13337 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2385708918</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2385708918</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4197-4ea1925ac917b1de0ff128b0e1c3d6d758b185e98f12d219c09a3f330890e56d3</originalsourceid><addsrcrecordid>eNp1kE1LAzEURYMotlYX_gEJuNHFtPloOjNLqV-FQhcquDJkkjeYOp3UZEbpvzd1qgvBt8njcnJJDkKnlAxpnJEzdkg55-ke6tMJoQnJmNiPOxfjRDD-3ENHISwJoWnO2SHqccZ4Sgjpo5cHVdkP5Td47V0DtsZa1cYa1UDApfO4sG6l_Bv4gF2JnVcVNjY4b7ZJxFWl3aurcLyFG1corR02sIbaQN2EY3RQqirAye4coKfbm8fpfTJf3M2mV_NEj2meJmNQNGdC6ZymBTVAypKyrCBANTcTk4qsoJmAPIuxYTTXJFe85JxkOQExMXyALrre-Iv3FkIjVzZoqCpVg2uDZDwTaaRpFtHzP-jStb6Or5NszIUgPEqK1GVHae9C8FDKtbdRxEZSIrfSZZQuv6VH9mzX2BYrML_kj-UIjDrg01aw-b9JLq5nXeUX4dWK9w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2435503793</pqid></control><display><type>article</type><title>Salivary protein candidates for biomarkers of oral disorders in alcohol and tobacco dependents</title><source>Access via Wiley Online Library</source><creator>Penteado, Carlos Antonio Schaffer ; Batista, Thiago Beltrami Dias ; Chaiben, Cassiano Lima ; Bonacin, Bruna Guedes ; Ventura, Talita M. O. ; Dionizio, Aline ; Couto Souza, Paulo Henrique ; Buzalaf, Marília Afonso Rabelo ; Azevedo‐Alanis, Luciana Reis</creator><creatorcontrib>Penteado, Carlos Antonio Schaffer ; Batista, Thiago Beltrami Dias ; Chaiben, Cassiano Lima ; Bonacin, Bruna Guedes ; Ventura, Talita M. O. ; Dionizio, Aline ; Couto Souza, Paulo Henrique ; Buzalaf, Marília Afonso Rabelo ; Azevedo‐Alanis, Luciana Reis</creatorcontrib><description>Objectives
To evaluate the oral condition of alcohol and tobacco dependents and identify salivary protein candidates for biomarkers of oral disorders.
Subjects and methods
Thirty‐three male volunteers were evaluated for alcohol abuse rehabilitation; nine were selected for proteomic analysis. Intraoral examination was performed, and non‐stimulated saliva was collected. Salivary proteins were extracted and processed for analysis. A list of proteins identified in saliva was generated from the database and manually revised, obtaining the total number of candidate biomarkers for oral disorders.
Results
The mean age (n = 33) was 42.94 ± 8.61 years. Fourteen (42.4%) subjects presented with 23 oral mucosa changes, and 31 (94%) had dental plaque. A total of 282 proteins were found in saliva (n = 9), of which 26 were identified as candidates for biomarkers of oral disorders. After manual review, 21 proteins were selected. The highest number of candidates for biomarkers was associated with carcinoma of head and neck (n = 10), nasopharyngeal carcinoma (n = 6), and periodontal disease (n = 6).
Conclusion
Alcohol and tobacco dependents showed gingival inflammation, and less than half of them showed oral mucosa changes. Twenty‐one protein candidates for biomarkers of oral disorders were identified in saliva. The two major oral disorders in number of candidates for biomarkers were head and neck cancer and periodontal disease.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.13337</identifier><identifier>PMID: 32237000</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Abuse ; Alcohol ; Alcohol abuse ; alcoholism ; Biomarkers ; Candidates ; Dental plaque ; Drug abuse ; Head & neck cancer ; head and neck cancer ; Mucosa ; Nasopharyngeal carcinoma ; Periodontal diseases ; Proteins ; proteomics ; Rehabilitation ; Saliva ; salivary proteins and peptides ; Tobacco ; tobacco use disorder</subject><ispartof>Oral diseases, 2020-09, Vol.26 (6), p.1200-1208</ispartof><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved</rights><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.</rights><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4197-4ea1925ac917b1de0ff128b0e1c3d6d758b185e98f12d219c09a3f330890e56d3</citedby><cites>FETCH-LOGICAL-c4197-4ea1925ac917b1de0ff128b0e1c3d6d758b185e98f12d219c09a3f330890e56d3</cites><orcidid>0000-0001-8809-3579</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.13337$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.13337$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27926,27927,45576,45577</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32237000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Penteado, Carlos Antonio Schaffer</creatorcontrib><creatorcontrib>Batista, Thiago Beltrami Dias</creatorcontrib><creatorcontrib>Chaiben, Cassiano Lima</creatorcontrib><creatorcontrib>Bonacin, Bruna Guedes</creatorcontrib><creatorcontrib>Ventura, Talita M. O.</creatorcontrib><creatorcontrib>Dionizio, Aline</creatorcontrib><creatorcontrib>Couto Souza, Paulo Henrique</creatorcontrib><creatorcontrib>Buzalaf, Marília Afonso Rabelo</creatorcontrib><creatorcontrib>Azevedo‐Alanis, Luciana Reis</creatorcontrib><title>Salivary protein candidates for biomarkers of oral disorders in alcohol and tobacco dependents</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objectives
To evaluate the oral condition of alcohol and tobacco dependents and identify salivary protein candidates for biomarkers of oral disorders.
Subjects and methods
Thirty‐three male volunteers were evaluated for alcohol abuse rehabilitation; nine were selected for proteomic analysis. Intraoral examination was performed, and non‐stimulated saliva was collected. Salivary proteins were extracted and processed for analysis. A list of proteins identified in saliva was generated from the database and manually revised, obtaining the total number of candidate biomarkers for oral disorders.
Results
The mean age (n = 33) was 42.94 ± 8.61 years. Fourteen (42.4%) subjects presented with 23 oral mucosa changes, and 31 (94%) had dental plaque. A total of 282 proteins were found in saliva (n = 9), of which 26 were identified as candidates for biomarkers of oral disorders. After manual review, 21 proteins were selected. The highest number of candidates for biomarkers was associated with carcinoma of head and neck (n = 10), nasopharyngeal carcinoma (n = 6), and periodontal disease (n = 6).
Conclusion
Alcohol and tobacco dependents showed gingival inflammation, and less than half of them showed oral mucosa changes. Twenty‐one protein candidates for biomarkers of oral disorders were identified in saliva. The two major oral disorders in number of candidates for biomarkers were head and neck cancer and periodontal disease.</description><subject>Abuse</subject><subject>Alcohol</subject><subject>Alcohol abuse</subject><subject>alcoholism</subject><subject>Biomarkers</subject><subject>Candidates</subject><subject>Dental plaque</subject><subject>Drug abuse</subject><subject>Head & neck cancer</subject><subject>head and neck cancer</subject><subject>Mucosa</subject><subject>Nasopharyngeal carcinoma</subject><subject>Periodontal diseases</subject><subject>Proteins</subject><subject>proteomics</subject><subject>Rehabilitation</subject><subject>Saliva</subject><subject>salivary proteins and peptides</subject><subject>Tobacco</subject><subject>tobacco use disorder</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LAzEURYMotlYX_gEJuNHFtPloOjNLqV-FQhcquDJkkjeYOp3UZEbpvzd1qgvBt8njcnJJDkKnlAxpnJEzdkg55-ke6tMJoQnJmNiPOxfjRDD-3ENHISwJoWnO2SHqccZ4Sgjpo5cHVdkP5Td47V0DtsZa1cYa1UDApfO4sG6l_Bv4gF2JnVcVNjY4b7ZJxFWl3aurcLyFG1corR02sIbaQN2EY3RQqirAye4coKfbm8fpfTJf3M2mV_NEj2meJmNQNGdC6ZymBTVAypKyrCBANTcTk4qsoJmAPIuxYTTXJFe85JxkOQExMXyALrre-Iv3FkIjVzZoqCpVg2uDZDwTaaRpFtHzP-jStb6Or5NszIUgPEqK1GVHae9C8FDKtbdRxEZSIrfSZZQuv6VH9mzX2BYrML_kj-UIjDrg01aw-b9JLq5nXeUX4dWK9w</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Penteado, Carlos Antonio Schaffer</creator><creator>Batista, Thiago Beltrami Dias</creator><creator>Chaiben, Cassiano Lima</creator><creator>Bonacin, Bruna Guedes</creator><creator>Ventura, Talita M. O.</creator><creator>Dionizio, Aline</creator><creator>Couto Souza, Paulo Henrique</creator><creator>Buzalaf, Marília Afonso Rabelo</creator><creator>Azevedo‐Alanis, Luciana Reis</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8809-3579</orcidid></search><sort><creationdate>202009</creationdate><title>Salivary protein candidates for biomarkers of oral disorders in alcohol and tobacco dependents</title><author>Penteado, Carlos Antonio Schaffer ; Batista, Thiago Beltrami Dias ; Chaiben, Cassiano Lima ; Bonacin, Bruna Guedes ; Ventura, Talita M. O. ; Dionizio, Aline ; Couto Souza, Paulo Henrique ; Buzalaf, Marília Afonso Rabelo ; Azevedo‐Alanis, Luciana Reis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4197-4ea1925ac917b1de0ff128b0e1c3d6d758b185e98f12d219c09a3f330890e56d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abuse</topic><topic>Alcohol</topic><topic>Alcohol abuse</topic><topic>alcoholism</topic><topic>Biomarkers</topic><topic>Candidates</topic><topic>Dental plaque</topic><topic>Drug abuse</topic><topic>Head & neck cancer</topic><topic>head and neck cancer</topic><topic>Mucosa</topic><topic>Nasopharyngeal carcinoma</topic><topic>Periodontal diseases</topic><topic>Proteins</topic><topic>proteomics</topic><topic>Rehabilitation</topic><topic>Saliva</topic><topic>salivary proteins and peptides</topic><topic>Tobacco</topic><topic>tobacco use disorder</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Penteado, Carlos Antonio Schaffer</creatorcontrib><creatorcontrib>Batista, Thiago Beltrami Dias</creatorcontrib><creatorcontrib>Chaiben, Cassiano Lima</creatorcontrib><creatorcontrib>Bonacin, Bruna Guedes</creatorcontrib><creatorcontrib>Ventura, Talita M. O.</creatorcontrib><creatorcontrib>Dionizio, Aline</creatorcontrib><creatorcontrib>Couto Souza, Paulo Henrique</creatorcontrib><creatorcontrib>Buzalaf, Marília Afonso Rabelo</creatorcontrib><creatorcontrib>Azevedo‐Alanis, Luciana Reis</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Penteado, Carlos Antonio Schaffer</au><au>Batista, Thiago Beltrami Dias</au><au>Chaiben, Cassiano Lima</au><au>Bonacin, Bruna Guedes</au><au>Ventura, Talita M. O.</au><au>Dionizio, Aline</au><au>Couto Souza, Paulo Henrique</au><au>Buzalaf, Marília Afonso Rabelo</au><au>Azevedo‐Alanis, Luciana Reis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salivary protein candidates for biomarkers of oral disorders in alcohol and tobacco dependents</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2020-09</date><risdate>2020</risdate><volume>26</volume><issue>6</issue><spage>1200</spage><epage>1208</epage><pages>1200-1208</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Objectives
To evaluate the oral condition of alcohol and tobacco dependents and identify salivary protein candidates for biomarkers of oral disorders.
Subjects and methods
Thirty‐three male volunteers were evaluated for alcohol abuse rehabilitation; nine were selected for proteomic analysis. Intraoral examination was performed, and non‐stimulated saliva was collected. Salivary proteins were extracted and processed for analysis. A list of proteins identified in saliva was generated from the database and manually revised, obtaining the total number of candidate biomarkers for oral disorders.
Results
The mean age (n = 33) was 42.94 ± 8.61 years. Fourteen (42.4%) subjects presented with 23 oral mucosa changes, and 31 (94%) had dental plaque. A total of 282 proteins were found in saliva (n = 9), of which 26 were identified as candidates for biomarkers of oral disorders. After manual review, 21 proteins were selected. The highest number of candidates for biomarkers was associated with carcinoma of head and neck (n = 10), nasopharyngeal carcinoma (n = 6), and periodontal disease (n = 6).
Conclusion
Alcohol and tobacco dependents showed gingival inflammation, and less than half of them showed oral mucosa changes. Twenty‐one protein candidates for biomarkers of oral disorders were identified in saliva. The two major oral disorders in number of candidates for biomarkers were head and neck cancer and periodontal disease.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32237000</pmid><doi>10.1111/odi.13337</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8809-3579</orcidid></addata></record> |
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| ispartof | Oral diseases, 2020-09, Vol.26 (6), p.1200-1208 |
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| language | eng |
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| source | Access via Wiley Online Library |
| subjects | Abuse Alcohol Alcohol abuse alcoholism Biomarkers Candidates Dental plaque Drug abuse Head & neck cancer head and neck cancer Mucosa Nasopharyngeal carcinoma Periodontal diseases Proteins proteomics Rehabilitation Saliva salivary proteins and peptides Tobacco tobacco use disorder |
| title | Salivary protein candidates for biomarkers of oral disorders in alcohol and tobacco dependents |
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