Extent of Peritoneal Metastases on Preoperative DW-MRI is Predictive of Disease-Free and Overall Survival for CRS/HIPEC Candidates with Colorectal Cancer
Objective The aim of this study was to determine whether the extent of peritoneal metastases (PMs) on preoperative diffusion-weighted magnetic resonance imaging (DW-MRI) can be used as a biomarker of disease-free and overall survival in patients with colorectal cancer who are considered for cytoredu...
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| Veröffentlicht in: | Annals of surgical oncology 2020-09, Vol.27 (9), p.3516-3524 |
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| creator | Engbersen, Maurits P. Aalbers, Arend G. J. Van‘t Sant-Jansen, Iris Velsing, Jeroen D. R. Lambregts, Doenja M. J. Beets-Tan, Regina G. H. Kok, Niels F. M. Lahaye, Max J. |
| description | Objective
The aim of this study was to determine whether the extent of peritoneal metastases (PMs) on preoperative diffusion-weighted magnetic resonance imaging (DW-MRI) can be used as a biomarker of disease-free and overall survival in patients with colorectal cancer who are considered for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).
Methods
For this retrospective cohort study, patients with PMs considered for CRS/HIPEC who underwent DW-MRI for preoperative staging in 2016–2017 were included. The DW-MRI protocol consisted of diffusion-weighted, T2-weighted, and pre- and post-gadolinium T1-weighted imaging of the chest, abdomen, and pelvis. DW-MRI images were evaluated by two independent readers to determine the extent of PMs represented by the Peritoneal Cancer Index (MRI-PCI), as well as extraperitoneal metastases. Cox regression and Kaplan–Meier analysis was performed to determine the prognostic value of DW-MRI for overall and disease-free survival.
Results
Seventy-eight patients were included. CRS/HIPEC was planned for 53 patients and completed in 50 patients (60.5%). Median follow-up after DW-MRI was 23 months (interquartile range 13–24). The MRI-PCI of both readers showed prognostic value for overall survival, independently of whether R1 resection was achieved (hazard ratio [HR] 1.06–1.08;
p
|
| doi_str_mv | 10.1245/s10434-020-08416-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2385708332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2430817172</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-cbc25052cb2b64a8bd3b6b652938daae98aafe2d7577bd2725117ec4fb14c3543</originalsourceid><addsrcrecordid>eNp9kV9rFDEUxQdRbK1-AR8k4Isvsfk7yT7KdGsXWrq0io8hydzRlNnJmmRW_Sh-W7PdquCDEEg493fODZymeUnJW8qEPM2UCC4wYQQTLWiL1aPmmMoqiVbTx_VNWo0XrJVHzbOc7wihihP5tDnijPEF5_q4-bn8XmAqKA5oDSmUOIEd0RUUm-uBjOKE1gniFpItYQfo7BO-ulmhkPdyH_y9WN1nIUM14PMEgOzUo-tdtYwjup3TLuxq6BAT6m5uTy9W62WHusqE3pa64lsoX1AXx5jAlwrWkYf0vHky2DHDi4f7pPl4vvzQXeDL6_er7t0l9lzJgr3zTBLJvGOuFVa7nrvWtZItuO6thYW2dgDWK6mU65liklIFXgyOCs-l4CfNm0PuNsWvM-RiNiF7GEc7QZyzYVxLRTTnrKKv_0Hv4pym-jvDBCeaKqr2FDtQPsWcEwxmm8LGph-GErMvzhyKM7U4c1-cUdX06iF6dhvo_1h-N1UBfgByHU2fIf3d_Z_YX0pDo6c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2430817172</pqid></control><display><type>article</type><title>Extent of Peritoneal Metastases on Preoperative DW-MRI is Predictive of Disease-Free and Overall Survival for CRS/HIPEC Candidates with Colorectal Cancer</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Engbersen, Maurits P. ; Aalbers, Arend G. J. ; Van‘t Sant-Jansen, Iris ; Velsing, Jeroen D. R. ; Lambregts, Doenja M. J. ; Beets-Tan, Regina G. H. ; Kok, Niels F. M. ; Lahaye, Max J.</creator><creatorcontrib>Engbersen, Maurits P. ; Aalbers, Arend G. J. ; Van‘t Sant-Jansen, Iris ; Velsing, Jeroen D. R. ; Lambregts, Doenja M. J. ; Beets-Tan, Regina G. H. ; Kok, Niels F. M. ; Lahaye, Max J.</creatorcontrib><description>Objective
The aim of this study was to determine whether the extent of peritoneal metastases (PMs) on preoperative diffusion-weighted magnetic resonance imaging (DW-MRI) can be used as a biomarker of disease-free and overall survival in patients with colorectal cancer who are considered for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).
Methods
For this retrospective cohort study, patients with PMs considered for CRS/HIPEC who underwent DW-MRI for preoperative staging in 2016–2017 were included. The DW-MRI protocol consisted of diffusion-weighted, T2-weighted, and pre- and post-gadolinium T1-weighted imaging of the chest, abdomen, and pelvis. DW-MRI images were evaluated by two independent readers to determine the extent of PMs represented by the Peritoneal Cancer Index (MRI-PCI), as well as extraperitoneal metastases. Cox regression and Kaplan–Meier analysis was performed to determine the prognostic value of DW-MRI for overall and disease-free survival.
Results
Seventy-eight patients were included. CRS/HIPEC was planned for 53 patients and completed in 50 patients (60.5%). Median follow-up after DW-MRI was 23 months (interquartile range 13–24). The MRI-PCI of both readers showed prognostic value for overall survival, independently of whether R1 resection was achieved (hazard ratio [HR] 1.06–1.08;
p
< 0.05). For the patients who received successful CRS/HIPEC, the MRI-PCI also showed independent prognostic value for disease-free survival for both readers (HR 1.09–1.10;
p
< 0.05).
Conclusion
The extent of PMs on preoperative DW-MRI is an independent predictor of overall and disease-free survival and should therefore be considered as a non-invasive prognostic biomarker.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-020-08416-7</identifier><identifier>PMID: 32239338</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Biomarkers ; Cancer ; Chemotherapy ; Chemotherapy, Cancer, Regional Perfusion ; Colorectal Cancer ; Colorectal carcinoma ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Diffusion Magnetic Resonance Imaging ; Disease-Free Survival ; Female ; Gadolinium ; Gastric cancer ; Humans ; Hyperthermic Intraperitoneal Chemotherapy ; Magnetic resonance imaging ; Male ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Middle Aged ; Neoplasm Staging ; Oncology ; Pelvis ; Peritoneal Neoplasms - diagnostic imaging ; Peritoneal Neoplasms - drug therapy ; Peritoneal Neoplasms - secondary ; Peritoneal Neoplasms - surgery ; Peritoneum ; Preoperative Care ; Prognosis ; Retrospective Studies ; Surgery ; Surgical Oncology ; Survival ; Survival Analysis ; Survival Rate</subject><ispartof>Annals of surgical oncology, 2020-09, Vol.27 (9), p.3516-3524</ispartof><rights>Society of Surgical Oncology 2020</rights><rights>Society of Surgical Oncology 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-cbc25052cb2b64a8bd3b6b652938daae98aafe2d7577bd2725117ec4fb14c3543</citedby><cites>FETCH-LOGICAL-c375t-cbc25052cb2b64a8bd3b6b652938daae98aafe2d7577bd2725117ec4fb14c3543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-020-08416-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-020-08416-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32239338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Engbersen, Maurits P.</creatorcontrib><creatorcontrib>Aalbers, Arend G. J.</creatorcontrib><creatorcontrib>Van‘t Sant-Jansen, Iris</creatorcontrib><creatorcontrib>Velsing, Jeroen D. R.</creatorcontrib><creatorcontrib>Lambregts, Doenja M. J.</creatorcontrib><creatorcontrib>Beets-Tan, Regina G. H.</creatorcontrib><creatorcontrib>Kok, Niels F. M.</creatorcontrib><creatorcontrib>Lahaye, Max J.</creatorcontrib><title>Extent of Peritoneal Metastases on Preoperative DW-MRI is Predictive of Disease-Free and Overall Survival for CRS/HIPEC Candidates with Colorectal Cancer</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Objective
The aim of this study was to determine whether the extent of peritoneal metastases (PMs) on preoperative diffusion-weighted magnetic resonance imaging (DW-MRI) can be used as a biomarker of disease-free and overall survival in patients with colorectal cancer who are considered for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).
Methods
For this retrospective cohort study, patients with PMs considered for CRS/HIPEC who underwent DW-MRI for preoperative staging in 2016–2017 were included. The DW-MRI protocol consisted of diffusion-weighted, T2-weighted, and pre- and post-gadolinium T1-weighted imaging of the chest, abdomen, and pelvis. DW-MRI images were evaluated by two independent readers to determine the extent of PMs represented by the Peritoneal Cancer Index (MRI-PCI), as well as extraperitoneal metastases. Cox regression and Kaplan–Meier analysis was performed to determine the prognostic value of DW-MRI for overall and disease-free survival.
Results
Seventy-eight patients were included. CRS/HIPEC was planned for 53 patients and completed in 50 patients (60.5%). Median follow-up after DW-MRI was 23 months (interquartile range 13–24). The MRI-PCI of both readers showed prognostic value for overall survival, independently of whether R1 resection was achieved (hazard ratio [HR] 1.06–1.08;
p
< 0.05). For the patients who received successful CRS/HIPEC, the MRI-PCI also showed independent prognostic value for disease-free survival for both readers (HR 1.09–1.10;
p
< 0.05).
Conclusion
The extent of PMs on preoperative DW-MRI is an independent predictor of overall and disease-free survival and should therefore be considered as a non-invasive prognostic biomarker.</description><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Biomarkers</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Cancer, Regional Perfusion</subject><subject>Colorectal Cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Combined Modality Therapy</subject><subject>Cytoreduction Surgical Procedures</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gadolinium</subject><subject>Gastric cancer</subject><subject>Humans</subject><subject>Hyperthermic Intraperitoneal Chemotherapy</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Pelvis</subject><subject>Peritoneal Neoplasms - diagnostic imaging</subject><subject>Peritoneal Neoplasms - drug therapy</subject><subject>Peritoneal Neoplasms - secondary</subject><subject>Peritoneal Neoplasms - surgery</subject><subject>Peritoneum</subject><subject>Preoperative Care</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Survival Rate</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kV9rFDEUxQdRbK1-AR8k4Isvsfk7yT7KdGsXWrq0io8hydzRlNnJmmRW_Sh-W7PdquCDEEg493fODZymeUnJW8qEPM2UCC4wYQQTLWiL1aPmmMoqiVbTx_VNWo0XrJVHzbOc7wihihP5tDnijPEF5_q4-bn8XmAqKA5oDSmUOIEd0RUUm-uBjOKE1gniFpItYQfo7BO-ulmhkPdyH_y9WN1nIUM14PMEgOzUo-tdtYwjup3TLuxq6BAT6m5uTy9W62WHusqE3pa64lsoX1AXx5jAlwrWkYf0vHky2DHDi4f7pPl4vvzQXeDL6_er7t0l9lzJgr3zTBLJvGOuFVa7nrvWtZItuO6thYW2dgDWK6mU65liklIFXgyOCs-l4CfNm0PuNsWvM-RiNiF7GEc7QZyzYVxLRTTnrKKv_0Hv4pym-jvDBCeaKqr2FDtQPsWcEwxmm8LGph-GErMvzhyKM7U4c1-cUdX06iF6dhvo_1h-N1UBfgByHU2fIf3d_Z_YX0pDo6c</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Engbersen, Maurits P.</creator><creator>Aalbers, Arend G. J.</creator><creator>Van‘t Sant-Jansen, Iris</creator><creator>Velsing, Jeroen D. R.</creator><creator>Lambregts, Doenja M. J.</creator><creator>Beets-Tan, Regina G. H.</creator><creator>Kok, Niels F. M.</creator><creator>Lahaye, Max J.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200901</creationdate><title>Extent of Peritoneal Metastases on Preoperative DW-MRI is Predictive of Disease-Free and Overall Survival for CRS/HIPEC Candidates with Colorectal Cancer</title><author>Engbersen, Maurits P. ; Aalbers, Arend G. J. ; Van‘t Sant-Jansen, Iris ; Velsing, Jeroen D. R. ; Lambregts, Doenja M. J. ; Beets-Tan, Regina G. H. ; Kok, Niels F. M. ; Lahaye, Max J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-cbc25052cb2b64a8bd3b6b652938daae98aafe2d7577bd2725117ec4fb14c3543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</topic><topic>Biomarkers</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Chemotherapy, Cancer, Regional Perfusion</topic><topic>Colorectal Cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Combined Modality Therapy</topic><topic>Cytoreduction Surgical Procedures</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gadolinium</topic><topic>Gastric cancer</topic><topic>Humans</topic><topic>Hyperthermic Intraperitoneal Chemotherapy</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Pelvis</topic><topic>Peritoneal Neoplasms - diagnostic imaging</topic><topic>Peritoneal Neoplasms - drug therapy</topic><topic>Peritoneal Neoplasms - secondary</topic><topic>Peritoneal Neoplasms - surgery</topic><topic>Peritoneum</topic><topic>Preoperative Care</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Engbersen, Maurits P.</creatorcontrib><creatorcontrib>Aalbers, Arend G. J.</creatorcontrib><creatorcontrib>Van‘t Sant-Jansen, Iris</creatorcontrib><creatorcontrib>Velsing, Jeroen D. R.</creatorcontrib><creatorcontrib>Lambregts, Doenja M. J.</creatorcontrib><creatorcontrib>Beets-Tan, Regina G. H.</creatorcontrib><creatorcontrib>Kok, Niels F. M.</creatorcontrib><creatorcontrib>Lahaye, Max J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Engbersen, Maurits P.</au><au>Aalbers, Arend G. J.</au><au>Van‘t Sant-Jansen, Iris</au><au>Velsing, Jeroen D. R.</au><au>Lambregts, Doenja M. J.</au><au>Beets-Tan, Regina G. H.</au><au>Kok, Niels F. M.</au><au>Lahaye, Max J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extent of Peritoneal Metastases on Preoperative DW-MRI is Predictive of Disease-Free and Overall Survival for CRS/HIPEC Candidates with Colorectal Cancer</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>27</volume><issue>9</issue><spage>3516</spage><epage>3524</epage><pages>3516-3524</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Objective
The aim of this study was to determine whether the extent of peritoneal metastases (PMs) on preoperative diffusion-weighted magnetic resonance imaging (DW-MRI) can be used as a biomarker of disease-free and overall survival in patients with colorectal cancer who are considered for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).
Methods
For this retrospective cohort study, patients with PMs considered for CRS/HIPEC who underwent DW-MRI for preoperative staging in 2016–2017 were included. The DW-MRI protocol consisted of diffusion-weighted, T2-weighted, and pre- and post-gadolinium T1-weighted imaging of the chest, abdomen, and pelvis. DW-MRI images were evaluated by two independent readers to determine the extent of PMs represented by the Peritoneal Cancer Index (MRI-PCI), as well as extraperitoneal metastases. Cox regression and Kaplan–Meier analysis was performed to determine the prognostic value of DW-MRI for overall and disease-free survival.
Results
Seventy-eight patients were included. CRS/HIPEC was planned for 53 patients and completed in 50 patients (60.5%). Median follow-up after DW-MRI was 23 months (interquartile range 13–24). The MRI-PCI of both readers showed prognostic value for overall survival, independently of whether R1 resection was achieved (hazard ratio [HR] 1.06–1.08;
p
< 0.05). For the patients who received successful CRS/HIPEC, the MRI-PCI also showed independent prognostic value for disease-free survival for both readers (HR 1.09–1.10;
p
< 0.05).
Conclusion
The extent of PMs on preoperative DW-MRI is an independent predictor of overall and disease-free survival and should therefore be considered as a non-invasive prognostic biomarker.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32239338</pmid><doi>10.1245/s10434-020-08416-7</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2020-09, Vol.27 (9), p.3516-3524 |
| issn | 1068-9265 1534-4681 |
| language | eng |
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| source | MEDLINE; Springer Online Journals Complete |
| subjects | Aged Antineoplastic Combined Chemotherapy Protocols - administration & dosage Biomarkers Cancer Chemotherapy Chemotherapy, Cancer, Regional Perfusion Colorectal Cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Combined Modality Therapy Cytoreduction Surgical Procedures Diffusion Magnetic Resonance Imaging Disease-Free Survival Female Gadolinium Gastric cancer Humans Hyperthermic Intraperitoneal Chemotherapy Magnetic resonance imaging Male Medicine Medicine & Public Health Metastases Metastasis Middle Aged Neoplasm Staging Oncology Pelvis Peritoneal Neoplasms - diagnostic imaging Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - secondary Peritoneal Neoplasms - surgery Peritoneum Preoperative Care Prognosis Retrospective Studies Surgery Surgical Oncology Survival Survival Analysis Survival Rate |
| title | Extent of Peritoneal Metastases on Preoperative DW-MRI is Predictive of Disease-Free and Overall Survival for CRS/HIPEC Candidates with Colorectal Cancer |
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