Obesity-associated methylation in breast tumors: a possible link to disparate outcomes?

Purpose As a primary risk factor and modifier of breast cancer incidence and prognosis, obesity may contribute to race disparities in breast cancer outcomes. This study examined association between obesity and DNA methylation in non-Hispanic Black and White women diagnosed with breast cancer. Method...

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Veröffentlicht in:	Breast cancer research and treatment 2020-05, Vol.181 (1), p.135-144
Hauptverfasser:	Do, Whitney L., Conneely, Karen, Gabram-Mendola, Sheryl, Krishnamurti, Uma, D’Angelo, Olivia, Miller-Kleinhenz, Jasmine, Gogineni, Keerthi, Torres, Mylin, McCullough, Lauren E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Black or African American - statistics & numerical data Body Mass Index Breast cancer Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - surgery Cancer Cancer research CpG Islands Cytosine Deoxyribonucleic acid DNA DNA Methylation Epidemiology Epigenesis, Genetic Estrogen Estrogen receptors Female Follow-Up Studies Genomes Guanine Health aspects Health risk assessment Humans Medical colleges Medicine Medicine & Public Health Methylation Middle Aged Mortality Obesity Obesity - physiopathology Oncology Oncology, Experimental Prognosis Pyrimidines Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Regression analysis Risk factors Survival Rate Tumors White People - statistics & numerical data
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