Protection of human retinal pigment epithelial cells from oxidative damage using cysteine prodrugs

Age-related macular degeneration (AMD) is one of the major causes of vision loss in the elderly in most developed countries. Among other causes, oxidative stress in the retinal pigment epithelium (RPE) has been hypothesized to be a major driving force of AMD pathology. Oxidative stress could be trea...

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Veröffentlicht in:	Free radical biology & medicine 2020-05, Vol.152, p.386-394
Hauptverfasser:	Kularatne, Ruvanthi N., Bulumulla, Chandima, Catchpole, Timothy, Takacs, Alison, Christie, Abigail, Stefan, Mihaela C., Csaky, Karl G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age-related macular degeneration Glutathione Mitochondria N-acetylcysteine butyl ester (NACBE) Oxidative stress
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