Vascularized neural constructs for ex-vivo reconstitution of blood-brain barrier function

Ex-vivo blood-brain barrier (BBB) model is of great value for studying brain function and drug development, but it is still challenging to engineer macroscale three-dimensional (3D) tissue constructs to recapitulate physiological and functional aspects of BBB. Here, we describe a delicate 3D vascula...

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Veröffentlicht in:	Biomaterials 2020-07, Vol.245, p.119980-119980, Article 119980
Hauptverfasser:	Yue, Haibing, Xie, Kai, Ji, Xianglin, Xu, Bingzhe, Wang, Chong, Shi, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	3D printing Blood-Brain Barrier Coculture Techniques Drug screening Endothelial Cells Neuro-engineering Organ on a chip Pericytes Tissue Engineering Vasculature network
Online-Zugang:	Volltext
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