Facile synthesis of copper doping hierarchical hollow porous hydroxyapatite beads by rapid gelling strategy
Calcium phosphate based ceramic materials are widely used in bone tissue engineering. Till now, it remains an unmet challenge to construct monodispersed hollow porous calcium phosphate beads through facile and scalable-production strategy. Herein, a rapid gelling strategy is used to combine the guar...
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| Veröffentlicht in: | Materials Science & Engineering C 2020-04, Vol.109, p.110531-110531, Article 110531 |
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| creator | Hui, Yang Dong, Zhang Wenkun, Peng Yao, Di Huichang, Gao Tongxiang, Liang |
| description | Calcium phosphate based ceramic materials are widely used in bone tissue engineering. Till now, it remains an unmet challenge to construct monodispersed hollow porous calcium phosphate beads through facile and scalable-production strategy. Herein, a rapid gelling strategy is used to combine the guar gum and metal hydroxide, which helps to prepare hollow hierarchical porous hydroxyapatite beads. Results show that the concentration of copper ions and calcination temperature greatly affect the microstructure transformation of the product. Higher concentrations of copper ions lead to the growth of hollow structures, and these ceramic beads exhibit excellent biocompatibility and antibacterial properties. The structure evolution of the products is systematically investigated, and a formation mechanism has been proposed.
•Hierarchical hollow porous hydroxyapatite beads have been synthesized by rapid gelling process.•Metal hydroxide plays key role in the crosslinking of guar gum.•CuHA beads owns excellent biocompatibility and antibacterial property. |
| doi_str_mv | 10.1016/j.msec.2019.110531 |
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Till now, it remains an unmet challenge to construct monodispersed hollow porous calcium phosphate beads through facile and scalable-production strategy. Herein, a rapid gelling strategy is used to combine the guar gum and metal hydroxide, which helps to prepare hollow hierarchical porous hydroxyapatite beads. Results show that the concentration of copper ions and calcination temperature greatly affect the microstructure transformation of the product. Higher concentrations of copper ions lead to the growth of hollow structures, and these ceramic beads exhibit excellent biocompatibility and antibacterial properties. The structure evolution of the products is systematically investigated, and a formation mechanism has been proposed.
•Hierarchical hollow porous hydroxyapatite beads have been synthesized by rapid gelling process.•Metal hydroxide plays key role in the crosslinking of guar gum.•CuHA beads owns excellent biocompatibility and antibacterial property.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32228968</pmid><doi>10.1016/j.msec.2019.110531</doi><tpages>1</tpages></addata></record> |
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| subjects | Antibacterial Beads Biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Calcium Calcium phosphate Calcium phosphates Cell Line Copper Copper - chemistry Copper - pharmacology Copper doping Durapatite - chemistry Durapatite - pharmacology Gel Gelation Guar gum Hollow structure Humans Hydroxyapatite Ions Materials science Materials Testing Porosity Strategy Tissue Engineering |
| title | Facile synthesis of copper doping hierarchical hollow porous hydroxyapatite beads by rapid gelling strategy |
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