Donor hepatectomy time influences ischemia-reperfusion injury of the biliary tree in donation after circulatory death liver transplantation
Donor hepatectomy time is associated with graft survival after liver transplantation. The aim of this study was to identify the impact of donor hepatectomy time on biliary injury during donation after circulatory death liver transplantation. First, bile duct biopsies of livers included in (pre)clini...
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| Veröffentlicht in: | Surgery 2020-07, Vol.168 (1), p.160-166 |
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| creator | van Leeuwen, Otto B. van Reeven, Marjolein van der Helm, Danny IJzermans, Jan N.M. de Meijer, Vincent E. van den Berg, Aad P. Darwish Murad, Sarwa van Hoek, Bart Alwayn, Ian P.J. Porte, Robert J. Polak, Wojciech G. |
| description | Donor hepatectomy time is associated with graft survival after liver transplantation. The aim of this study was to identify the impact of donor hepatectomy time on biliary injury during donation after circulatory death liver transplantation.
First, bile duct biopsies of livers included in (pre)clinical machine perfusion research were analyzed. Secondly, of the same livers, bile samples were collected during normothermic machine perfusion. Lastly, a nationwide retrospective cohort study was performed including 273 adult patients undergoing donation after circulatory death liver transplantation between January 1, 2002 and January 1, 2017. Primary endpoint was development of non-anastomotic biliary strictures within 2 years of donation after circulatory death liver transplantation. Cox proportional-hazards regression analyses were used to assess the influence of hepatectomy time on the development of non-anastomotic biliary strictures.
Livers with severe histological bile duct injury had a higher median hepatectomy time (P = .03). During normothermic machine perfusion, livers with a hepatectomy time >50 minutes had lower biliary bicarbonate and bile pH levels. In the nationwide retrospective study, donor hepatectomy time was an independent risk factor for non-anastomotic biliary strictures after donation after circulatory death liver transplantation (Hazard Ratio 1.18 per 10 minutes increase, 95% Confidence Interval 1.06–1.30, P value = .002).
Donor hepatectomy time negatively influences histological bile duct injury before normothermic machine perfusion and bile composition during normothermic machine perfusion. Additionally, hepatectomy time is a significant independent risk factor for the development of non-anastomotic biliary strictures after donation after circulatory death liver transplantation. |
| doi_str_mv | 10.1016/j.surg.2020.02.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2384844275</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0039606020300714</els_id><sourcerecordid>2384844275</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-595725ba0dc9b772282f46526cb45fc44e396c068c69256d2594a198cea936a43</originalsourceid><addsrcrecordid>eNp9kU2O1DAQhS0EYnoGLsACeckmoeK_xBIbNPwM0khsYG05ToV2K4mD7Yw0d-AQnIWT4dADS1ZWyd97qlePkBcN1A006vWpTlv8VjNgUAOrAeQjcmgkZ1XLVfOYHAC4rhQouCCXKZ0AQIume0ouOGOM604cyI93YQmRHnG1GV0O8z3Nfkbql3HacHGYqE_uiLO3VcQV47glH5byf9riPQ0jzUekvZ-8LWOOuEvpEBabd8yOGSN1PrptsjkUZECbj3Tydxh__czRLmmd7JL_4M_Ik9FOCZ8_vFfk64f3X65vqtvPHz9dv72tnADIldSyZbK3MDjdty1jHRuFkky5XsjRCYFcKweqc0ozqQYmtbCN7hxazZUV_Iq8OvuuMXzfMGUzl5A4lUUwbMkw3olOCNbKgrIz6mJIKeJo1ujnktU0YPYWzMnsLZi9BQPMlBaK6OWD_9bPOPyT_D17Ad6cASwp7zxGk5zfrz34WFowQ_D_8_8NXSGc8A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2384844275</pqid></control><display><type>article</type><title>Donor hepatectomy time influences ischemia-reperfusion injury of the biliary tree in donation after circulatory death liver transplantation</title><source>Elsevier ScienceDirect Journals Complete</source><creator>van Leeuwen, Otto B. ; van Reeven, Marjolein ; van der Helm, Danny ; IJzermans, Jan N.M. ; de Meijer, Vincent E. ; van den Berg, Aad P. ; Darwish Murad, Sarwa ; van Hoek, Bart ; Alwayn, Ian P.J. ; Porte, Robert J. ; Polak, Wojciech G.</creator><creatorcontrib>van Leeuwen, Otto B. ; van Reeven, Marjolein ; van der Helm, Danny ; IJzermans, Jan N.M. ; de Meijer, Vincent E. ; van den Berg, Aad P. ; Darwish Murad, Sarwa ; van Hoek, Bart ; Alwayn, Ian P.J. ; Porte, Robert J. ; Polak, Wojciech G.</creatorcontrib><description>Donor hepatectomy time is associated with graft survival after liver transplantation. The aim of this study was to identify the impact of donor hepatectomy time on biliary injury during donation after circulatory death liver transplantation.
First, bile duct biopsies of livers included in (pre)clinical machine perfusion research were analyzed. Secondly, of the same livers, bile samples were collected during normothermic machine perfusion. Lastly, a nationwide retrospective cohort study was performed including 273 adult patients undergoing donation after circulatory death liver transplantation between January 1, 2002 and January 1, 2017. Primary endpoint was development of non-anastomotic biliary strictures within 2 years of donation after circulatory death liver transplantation. Cox proportional-hazards regression analyses were used to assess the influence of hepatectomy time on the development of non-anastomotic biliary strictures.
Livers with severe histological bile duct injury had a higher median hepatectomy time (P = .03). During normothermic machine perfusion, livers with a hepatectomy time >50 minutes had lower biliary bicarbonate and bile pH levels. In the nationwide retrospective study, donor hepatectomy time was an independent risk factor for non-anastomotic biliary strictures after donation after circulatory death liver transplantation (Hazard Ratio 1.18 per 10 minutes increase, 95% Confidence Interval 1.06–1.30, P value = .002).
Donor hepatectomy time negatively influences histological bile duct injury before normothermic machine perfusion and bile composition during normothermic machine perfusion. Additionally, hepatectomy time is a significant independent risk factor for the development of non-anastomotic biliary strictures after donation after circulatory death liver transplantation.</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/j.surg.2020.02.005</identifier><identifier>PMID: 32223984</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><ispartof>Surgery, 2020-07, Vol.168 (1), p.160-166</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-595725ba0dc9b772282f46526cb45fc44e396c068c69256d2594a198cea936a43</citedby><cites>FETCH-LOGICAL-c400t-595725ba0dc9b772282f46526cb45fc44e396c068c69256d2594a198cea936a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0039606020300714$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32223984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Leeuwen, Otto B.</creatorcontrib><creatorcontrib>van Reeven, Marjolein</creatorcontrib><creatorcontrib>van der Helm, Danny</creatorcontrib><creatorcontrib>IJzermans, Jan N.M.</creatorcontrib><creatorcontrib>de Meijer, Vincent E.</creatorcontrib><creatorcontrib>van den Berg, Aad P.</creatorcontrib><creatorcontrib>Darwish Murad, Sarwa</creatorcontrib><creatorcontrib>van Hoek, Bart</creatorcontrib><creatorcontrib>Alwayn, Ian P.J.</creatorcontrib><creatorcontrib>Porte, Robert J.</creatorcontrib><creatorcontrib>Polak, Wojciech G.</creatorcontrib><title>Donor hepatectomy time influences ischemia-reperfusion injury of the biliary tree in donation after circulatory death liver transplantation</title><title>Surgery</title><addtitle>Surgery</addtitle><description>Donor hepatectomy time is associated with graft survival after liver transplantation. The aim of this study was to identify the impact of donor hepatectomy time on biliary injury during donation after circulatory death liver transplantation.
First, bile duct biopsies of livers included in (pre)clinical machine perfusion research were analyzed. Secondly, of the same livers, bile samples were collected during normothermic machine perfusion. Lastly, a nationwide retrospective cohort study was performed including 273 adult patients undergoing donation after circulatory death liver transplantation between January 1, 2002 and January 1, 2017. Primary endpoint was development of non-anastomotic biliary strictures within 2 years of donation after circulatory death liver transplantation. Cox proportional-hazards regression analyses were used to assess the influence of hepatectomy time on the development of non-anastomotic biliary strictures.
Livers with severe histological bile duct injury had a higher median hepatectomy time (P = .03). During normothermic machine perfusion, livers with a hepatectomy time >50 minutes had lower biliary bicarbonate and bile pH levels. In the nationwide retrospective study, donor hepatectomy time was an independent risk factor for non-anastomotic biliary strictures after donation after circulatory death liver transplantation (Hazard Ratio 1.18 per 10 minutes increase, 95% Confidence Interval 1.06–1.30, P value = .002).
Donor hepatectomy time negatively influences histological bile duct injury before normothermic machine perfusion and bile composition during normothermic machine perfusion. Additionally, hepatectomy time is a significant independent risk factor for the development of non-anastomotic biliary strictures after donation after circulatory death liver transplantation.</description><issn>0039-6060</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU2O1DAQhS0EYnoGLsACeckmoeK_xBIbNPwM0khsYG05ToV2K4mD7Yw0d-AQnIWT4dADS1ZWyd97qlePkBcN1A006vWpTlv8VjNgUAOrAeQjcmgkZ1XLVfOYHAC4rhQouCCXKZ0AQIume0ouOGOM604cyI93YQmRHnG1GV0O8z3Nfkbql3HacHGYqE_uiLO3VcQV47glH5byf9riPQ0jzUekvZ-8LWOOuEvpEBabd8yOGSN1PrptsjkUZECbj3Tydxh__czRLmmd7JL_4M_Ik9FOCZ8_vFfk64f3X65vqtvPHz9dv72tnADIldSyZbK3MDjdty1jHRuFkky5XsjRCYFcKweqc0ozqQYmtbCN7hxazZUV_Iq8OvuuMXzfMGUzl5A4lUUwbMkw3olOCNbKgrIz6mJIKeJo1ujnktU0YPYWzMnsLZi9BQPMlBaK6OWD_9bPOPyT_D17Ad6cASwp7zxGk5zfrz34WFowQ_D_8_8NXSGc8A</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>van Leeuwen, Otto B.</creator><creator>van Reeven, Marjolein</creator><creator>van der Helm, Danny</creator><creator>IJzermans, Jan N.M.</creator><creator>de Meijer, Vincent E.</creator><creator>van den Berg, Aad P.</creator><creator>Darwish Murad, Sarwa</creator><creator>van Hoek, Bart</creator><creator>Alwayn, Ian P.J.</creator><creator>Porte, Robert J.</creator><creator>Polak, Wojciech G.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200701</creationdate><title>Donor hepatectomy time influences ischemia-reperfusion injury of the biliary tree in donation after circulatory death liver transplantation</title><author>van Leeuwen, Otto B. ; van Reeven, Marjolein ; van der Helm, Danny ; IJzermans, Jan N.M. ; de Meijer, Vincent E. ; van den Berg, Aad P. ; Darwish Murad, Sarwa ; van Hoek, Bart ; Alwayn, Ian P.J. ; Porte, Robert J. ; Polak, Wojciech G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-595725ba0dc9b772282f46526cb45fc44e396c068c69256d2594a198cea936a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Leeuwen, Otto B.</creatorcontrib><creatorcontrib>van Reeven, Marjolein</creatorcontrib><creatorcontrib>van der Helm, Danny</creatorcontrib><creatorcontrib>IJzermans, Jan N.M.</creatorcontrib><creatorcontrib>de Meijer, Vincent E.</creatorcontrib><creatorcontrib>van den Berg, Aad P.</creatorcontrib><creatorcontrib>Darwish Murad, Sarwa</creatorcontrib><creatorcontrib>van Hoek, Bart</creatorcontrib><creatorcontrib>Alwayn, Ian P.J.</creatorcontrib><creatorcontrib>Porte, Robert J.</creatorcontrib><creatorcontrib>Polak, Wojciech G.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Leeuwen, Otto B.</au><au>van Reeven, Marjolein</au><au>van der Helm, Danny</au><au>IJzermans, Jan N.M.</au><au>de Meijer, Vincent E.</au><au>van den Berg, Aad P.</au><au>Darwish Murad, Sarwa</au><au>van Hoek, Bart</au><au>Alwayn, Ian P.J.</au><au>Porte, Robert J.</au><au>Polak, Wojciech G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Donor hepatectomy time influences ischemia-reperfusion injury of the biliary tree in donation after circulatory death liver transplantation</atitle><jtitle>Surgery</jtitle><addtitle>Surgery</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>168</volume><issue>1</issue><spage>160</spage><epage>166</epage><pages>160-166</pages><issn>0039-6060</issn><eissn>1532-7361</eissn><abstract>Donor hepatectomy time is associated with graft survival after liver transplantation. The aim of this study was to identify the impact of donor hepatectomy time on biliary injury during donation after circulatory death liver transplantation.
First, bile duct biopsies of livers included in (pre)clinical machine perfusion research were analyzed. Secondly, of the same livers, bile samples were collected during normothermic machine perfusion. Lastly, a nationwide retrospective cohort study was performed including 273 adult patients undergoing donation after circulatory death liver transplantation between January 1, 2002 and January 1, 2017. Primary endpoint was development of non-anastomotic biliary strictures within 2 years of donation after circulatory death liver transplantation. Cox proportional-hazards regression analyses were used to assess the influence of hepatectomy time on the development of non-anastomotic biliary strictures.
Livers with severe histological bile duct injury had a higher median hepatectomy time (P = .03). During normothermic machine perfusion, livers with a hepatectomy time >50 minutes had lower biliary bicarbonate and bile pH levels. In the nationwide retrospective study, donor hepatectomy time was an independent risk factor for non-anastomotic biliary strictures after donation after circulatory death liver transplantation (Hazard Ratio 1.18 per 10 minutes increase, 95% Confidence Interval 1.06–1.30, P value = .002).
Donor hepatectomy time negatively influences histological bile duct injury before normothermic machine perfusion and bile composition during normothermic machine perfusion. Additionally, hepatectomy time is a significant independent risk factor for the development of non-anastomotic biliary strictures after donation after circulatory death liver transplantation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32223984</pmid><doi>10.1016/j.surg.2020.02.005</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| title | Donor hepatectomy time influences ischemia-reperfusion injury of the biliary tree in donation after circulatory death liver transplantation |
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