Characterization of N-(2,6-dimethylphenyl)hydroxylamine adducts of 2′-deoxyguanosine under weakly basic conditions

Aromatic amines are a class of chemical carcinogens that are activated by cytochrome P450 enzymes to form arylhydroxylamines that are conjugated to form N-acetoxyarylamines or N-sulfonyloxyarylamines. These conjugates undergo N–O bond cleavage to become reactive nitrenium ions that may form DNA addu...

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Veröffentlicht in:	Chemosphere (Oxford) 2020-08, Vol.252, p.126530-126530, Article 126530
Hauptverfasser:	Matsui, Takuya, Yamada, Naohito, Kuno, Hideyuki, Kanaly, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2,6-dimethylaniline 2′-deoxyguanosine Aromatic amines DNA adducts LC-HRMS N-(2,6-dimethylphenyl)hydroxylamine
Online-Zugang:	Volltext
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