Translation of the copper/bipyridine-promoted Petasis reaction to solid phase-coupled DNA for encoded library synthesis

[Display omitted] The Petasis three-component reaction gives rise to diverse substituted α-aryl glycines from readily available amines, boronic acids and glyoxalic acid. Thus, this reaction is highly attractive for DNA-encoded small molecule screening library synthesis. The Petasis reaction is for i...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2020-05, Vol.28 (9), p.115441-115441, Article 115441
Hauptverfasser:	Potowski, Marco, Esken, Robin, Brunschweiger, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA-encoded library Encoded chemistry Multicomponent reaction Petasis reaction α-aryl glycines
Online-Zugang:	Volltext
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