Distance dependent shedding of IL-6R

Proteolytic processing of membrane proteins by A disintegrin and metalloprotease-17 (ADAM17) is a key regulatory step in many physiological and pathophysiological processes. This so-called shedding is essential for development, regeneration and immune defense. An uncontrolled ADAM17 activity promote...

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Veröffentlicht in:	Biochemical and biophysical research communications 2020-05, Vol.526 (2), p.355-360
Hauptverfasser:	Düsterhöft, Stefan, Bartels, Anne-Kathrin, Koudelka, Tomas, Lilienthal, Eva, Schäfer, Miriam, Garbers, Christoph, Tholey, Andreas, Grötzinger, Joachim, Lorenzen, Inken
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation ADAM17 ADAM17 Protein - chemistry ADAM17 Protein - metabolism Amino Acid Sequence Catalytic Domain Conformational change HEK293 Cells Humans Interleukin-6 receptor Mutation Phosphatidylserines - metabolism Proteolysis Receptors, Interleukin-6 - chemistry Receptors, Interleukin-6 - genetics Receptors, Interleukin-6 - metabolism Shedding activity
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