Safety and immunogenicity of the tetravalent, live-attenuated dengue vaccine Butantan-DV in adults in Brazil: a two-step, double-blind, randomised placebo-controlled phase 2 trial

The Butantan Institute has manufactured a lyophilised tetravalent live-attenuated dengue vaccine Butantan-DV, which is analogous to the US National Institutes of Health (NIH) TV003 admixture. We aimed to assess the safety and immunogenicity of Butantan-DV. We did a two-step, double-blind, randomised...

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Veröffentlicht in:	The Lancet infectious diseases 2020-07, Vol.20 (7), p.839-850
Hauptverfasser:	Kallas, Esper G, Precioso, Alexander Roberto, Palacios, Ricardo, Thomé, Beatriz, Braga, Patrícia Emília, Vanni, Tazio, Campos, Lúcia M A, Ferrari, Lilian, Mondini, Gabriella, da Graça Salomão, Maria, da Silva, Anderson, Espinola, Heloisa M, do Prado Santos, Joane, Santos, Cecilia L S, Timenetsky, Maria do Carmo S T, Miraglia, João Luiz, Gallina, Neuza M F, Weiskopf, Daniela, Sette, Alessandro, Goulart, Raphaella, Salles, Rafael Tavares, Maestri, Alvino, Sallum, Adriana Maluf Elias, Farhat, Sylvia Costa Lima, Sakita, Neusa K, Ferreira, Juliana C O A, Silveira, Cassia G T, Costa, Priscilla R, Raw, Isaias, Whitehead, Stephen S, Durbin, Anna P, Kalil, Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Analysis Antibodies Autoimmune diseases Clinical trials Collection Dengue Dengue fever Diabetes mellitus Double-blind studies Exposure Hepatitis C HIV Human immunodeficiency virus Immunogenicity Infections Infectious diseases Kidney diseases Laboratories Licenses Liver diseases Lung diseases Pregnancy Public health Randomization Safety Seroconversion Serology Serotypes Side effects Studies Vaccination Vaccines Vector-borne diseases Viremia Viruses
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