Predicting Recovery and Outcome after Pediatric Stroke: Results from the International Pediatric Stroke Study
Objective To characterize predictors of recovery and outcome following pediatric arterial ischemic stroke, hypothesizing that age influences recovery after stroke. Methods We studied children enrolled in the International Pediatric Stroke Study between January 1, 2003 and July 31, 2014 with 2‐year f...
Gespeichert in:
| Veröffentlicht in: | Annals of neurology 2020-06, Vol.87 (6), p.840-852 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 852 |
|---|---|
| container_issue | 6 |
| container_start_page | 840 |
| container_title | Annals of neurology |
| container_volume | 87 |
| creator | Felling, Ryan J. Rafay, Mubeen F. Bernard, Timothy J. Carpenter, Jessica L. Dlamini, Nomazulu Hassanein, Sahar M. A. Jordan, Lori C. Noetzel, Michael J. Rivkin, Michael J. Shapiro, Kevin A. Slim, Mahmoud deVeber, Gabrielle |
| description | Objective
To characterize predictors of recovery and outcome following pediatric arterial ischemic stroke, hypothesizing that age influences recovery after stroke.
Methods
We studied children enrolled in the International Pediatric Stroke Study between January 1, 2003 and July 31, 2014 with 2‐year follow‐up after arterial ischemic stroke. Outcomes were defined at discharge by clinician grading and at 2 years by the Pediatric Stroke Outcome Measure. Demographic, clinical, and radiologic outcome predictors were examined. We defined changes in outcome from discharge to 2 years as recovery (improved outcome), emerging deficit (worse outcome), or no change.
Results
Our population consisted of 587 patients, including 174 with neonatal stroke and 413 with childhood stroke, with recurrent stroke in 8.2% of childhood patients. Moderate to severe neurological impairment was present in 9.4% of neonates versus 48.8% of children at discharge compared to 8.0% versus 24.7% after 2 years. Predictors of poor outcome included age between 28 days and 1 year (compared to neonates, odds ratio [OR] = 3.58, p |
| doi_str_mv | 10.1002/ana.25718 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2384211051</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2405201161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3888-4dbdd2727842547f73de925e2cfe87aea8378639505d8dde99d2d9e02ec869633</originalsourceid><addsrcrecordid>eNp10ctKxDAUBuAgio6jC19AAm50USeXpk3cDeINBhUv6xKTU622jSapMm9vdNSF4uos8p0fcn6EtijZp4Swie71PhMllUtoRAWnmWS5WkYjwos8E5Tna2g9hEdCiCooWUVrnDEqVKFGqLv0YBsTm_4eX4Fxr-DnWPcWXwzRuA6wriN4fJmQjr4x-Dp69wQHCYehjQHX3nU4PgA-6xPsdWxcr9s_C2kMdr6BVmrdBtj8mmN0e3x0c3iazS5Ozg6ns8xwKWWW2ztrWclKmTORl3XJLSgmgJkaZKlBS17KgitBhJU2vSnLrALCwMhCFZyP0e4i99m7lwFCrLomGGhb3YMbQsV4SqaUpNuM0c4v-uiG9I82qZwIRigtPtTeQhnvQvBQV8--6bSfV5RUHx1UqYPqs4Nkt78Sh7sO7I_8PnoCkwV4a1qY_59UTc-ni8h3GKOQMw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2405201161</pqid></control><display><type>article</type><title>Predicting Recovery and Outcome after Pediatric Stroke: Results from the International Pediatric Stroke Study</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Felling, Ryan J. ; Rafay, Mubeen F. ; Bernard, Timothy J. ; Carpenter, Jessica L. ; Dlamini, Nomazulu ; Hassanein, Sahar M. A. ; Jordan, Lori C. ; Noetzel, Michael J. ; Rivkin, Michael J. ; Shapiro, Kevin A. ; Slim, Mahmoud ; deVeber, Gabrielle</creator><creatorcontrib>Felling, Ryan J. ; Rafay, Mubeen F. ; Bernard, Timothy J. ; Carpenter, Jessica L. ; Dlamini, Nomazulu ; Hassanein, Sahar M. A. ; Jordan, Lori C. ; Noetzel, Michael J. ; Rivkin, Michael J. ; Shapiro, Kevin A. ; Slim, Mahmoud ; deVeber, Gabrielle ; International Pediatric Stroke Study Group ; the International Pediatric Stroke Study Group</creatorcontrib><description>Objective
To characterize predictors of recovery and outcome following pediatric arterial ischemic stroke, hypothesizing that age influences recovery after stroke.
Methods
We studied children enrolled in the International Pediatric Stroke Study between January 1, 2003 and July 31, 2014 with 2‐year follow‐up after arterial ischemic stroke. Outcomes were defined at discharge by clinician grading and at 2 years by the Pediatric Stroke Outcome Measure. Demographic, clinical, and radiologic outcome predictors were examined. We defined changes in outcome from discharge to 2 years as recovery (improved outcome), emerging deficit (worse outcome), or no change.
Results
Our population consisted of 587 patients, including 174 with neonatal stroke and 413 with childhood stroke, with recurrent stroke in 8.2% of childhood patients. Moderate to severe neurological impairment was present in 9.4% of neonates versus 48.8% of children at discharge compared to 8.0% versus 24.7% after 2 years. Predictors of poor outcome included age between 28 days and 1 year (compared to neonates, odds ratio [OR] = 3.58, p < 0.05), underlying chronic disorder (OR = 2.23, p < 0.05), and involvement of both small and large vascular territories (OR = 2.84, p < 0.05). Recovery patterns differed, with emerging deficits more common in children <1 year of age (p < 0.05).
Interpretation
Outcomes after pediatric stroke are generally favorable, but moderate to severe neurological impairments are still common. Age between 28 days and 1 year appears to be a particularly vulnerable period. Understanding the timing and predictors of recovery will allow us to better counsel families and target therapies to improve outcomes after pediatric stroke. ANN NEUROL 2020;87:840–852</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.25718</identifier><identifier>PMID: 32215969</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Age ; Children ; Discharge ; Ischemia ; Neonates ; Neurological complications ; Patients ; Pediatrics ; Recovery ; Stroke</subject><ispartof>Annals of neurology, 2020-06, Vol.87 (6), p.840-852</ispartof><rights>2020 American Neurological Association</rights><rights>2020 American Neurological Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3888-4dbdd2727842547f73de925e2cfe87aea8378639505d8dde99d2d9e02ec869633</citedby><cites>FETCH-LOGICAL-c3888-4dbdd2727842547f73de925e2cfe87aea8378639505d8dde99d2d9e02ec869633</cites><orcidid>0000-0002-0191-8425 ; 0000-0002-0845-9356</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.25718$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.25718$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32215969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Felling, Ryan J.</creatorcontrib><creatorcontrib>Rafay, Mubeen F.</creatorcontrib><creatorcontrib>Bernard, Timothy J.</creatorcontrib><creatorcontrib>Carpenter, Jessica L.</creatorcontrib><creatorcontrib>Dlamini, Nomazulu</creatorcontrib><creatorcontrib>Hassanein, Sahar M. A.</creatorcontrib><creatorcontrib>Jordan, Lori C.</creatorcontrib><creatorcontrib>Noetzel, Michael J.</creatorcontrib><creatorcontrib>Rivkin, Michael J.</creatorcontrib><creatorcontrib>Shapiro, Kevin A.</creatorcontrib><creatorcontrib>Slim, Mahmoud</creatorcontrib><creatorcontrib>deVeber, Gabrielle</creatorcontrib><creatorcontrib>International Pediatric Stroke Study Group</creatorcontrib><creatorcontrib>the International Pediatric Stroke Study Group</creatorcontrib><title>Predicting Recovery and Outcome after Pediatric Stroke: Results from the International Pediatric Stroke Study</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Objective
To characterize predictors of recovery and outcome following pediatric arterial ischemic stroke, hypothesizing that age influences recovery after stroke.
Methods
We studied children enrolled in the International Pediatric Stroke Study between January 1, 2003 and July 31, 2014 with 2‐year follow‐up after arterial ischemic stroke. Outcomes were defined at discharge by clinician grading and at 2 years by the Pediatric Stroke Outcome Measure. Demographic, clinical, and radiologic outcome predictors were examined. We defined changes in outcome from discharge to 2 years as recovery (improved outcome), emerging deficit (worse outcome), or no change.
Results
Our population consisted of 587 patients, including 174 with neonatal stroke and 413 with childhood stroke, with recurrent stroke in 8.2% of childhood patients. Moderate to severe neurological impairment was present in 9.4% of neonates versus 48.8% of children at discharge compared to 8.0% versus 24.7% after 2 years. Predictors of poor outcome included age between 28 days and 1 year (compared to neonates, odds ratio [OR] = 3.58, p < 0.05), underlying chronic disorder (OR = 2.23, p < 0.05), and involvement of both small and large vascular territories (OR = 2.84, p < 0.05). Recovery patterns differed, with emerging deficits more common in children <1 year of age (p < 0.05).
Interpretation
Outcomes after pediatric stroke are generally favorable, but moderate to severe neurological impairments are still common. Age between 28 days and 1 year appears to be a particularly vulnerable period. Understanding the timing and predictors of recovery will allow us to better counsel families and target therapies to improve outcomes after pediatric stroke. ANN NEUROL 2020;87:840–852</description><subject>Age</subject><subject>Children</subject><subject>Discharge</subject><subject>Ischemia</subject><subject>Neonates</subject><subject>Neurological complications</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Recovery</subject><subject>Stroke</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp10ctKxDAUBuAgio6jC19AAm50USeXpk3cDeINBhUv6xKTU622jSapMm9vdNSF4uos8p0fcn6EtijZp4Swie71PhMllUtoRAWnmWS5WkYjwos8E5Tna2g9hEdCiCooWUVrnDEqVKFGqLv0YBsTm_4eX4Fxr-DnWPcWXwzRuA6wriN4fJmQjr4x-Dp69wQHCYehjQHX3nU4PgA-6xPsdWxcr9s_C2kMdr6BVmrdBtj8mmN0e3x0c3iazS5Ozg6ns8xwKWWW2ztrWclKmTORl3XJLSgmgJkaZKlBS17KgitBhJU2vSnLrALCwMhCFZyP0e4i99m7lwFCrLomGGhb3YMbQsV4SqaUpNuM0c4v-uiG9I82qZwIRigtPtTeQhnvQvBQV8--6bSfV5RUHx1UqYPqs4Nkt78Sh7sO7I_8PnoCkwV4a1qY_59UTc-ni8h3GKOQMw</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Felling, Ryan J.</creator><creator>Rafay, Mubeen F.</creator><creator>Bernard, Timothy J.</creator><creator>Carpenter, Jessica L.</creator><creator>Dlamini, Nomazulu</creator><creator>Hassanein, Sahar M. A.</creator><creator>Jordan, Lori C.</creator><creator>Noetzel, Michael J.</creator><creator>Rivkin, Michael J.</creator><creator>Shapiro, Kevin A.</creator><creator>Slim, Mahmoud</creator><creator>deVeber, Gabrielle</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0191-8425</orcidid><orcidid>https://orcid.org/0000-0002-0845-9356</orcidid></search><sort><creationdate>202006</creationdate><title>Predicting Recovery and Outcome after Pediatric Stroke: Results from the International Pediatric Stroke Study</title><author>Felling, Ryan J. ; Rafay, Mubeen F. ; Bernard, Timothy J. ; Carpenter, Jessica L. ; Dlamini, Nomazulu ; Hassanein, Sahar M. A. ; Jordan, Lori C. ; Noetzel, Michael J. ; Rivkin, Michael J. ; Shapiro, Kevin A. ; Slim, Mahmoud ; deVeber, Gabrielle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3888-4dbdd2727842547f73de925e2cfe87aea8378639505d8dde99d2d9e02ec869633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Children</topic><topic>Discharge</topic><topic>Ischemia</topic><topic>Neonates</topic><topic>Neurological complications</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Recovery</topic><topic>Stroke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Felling, Ryan J.</creatorcontrib><creatorcontrib>Rafay, Mubeen F.</creatorcontrib><creatorcontrib>Bernard, Timothy J.</creatorcontrib><creatorcontrib>Carpenter, Jessica L.</creatorcontrib><creatorcontrib>Dlamini, Nomazulu</creatorcontrib><creatorcontrib>Hassanein, Sahar M. A.</creatorcontrib><creatorcontrib>Jordan, Lori C.</creatorcontrib><creatorcontrib>Noetzel, Michael J.</creatorcontrib><creatorcontrib>Rivkin, Michael J.</creatorcontrib><creatorcontrib>Shapiro, Kevin A.</creatorcontrib><creatorcontrib>Slim, Mahmoud</creatorcontrib><creatorcontrib>deVeber, Gabrielle</creatorcontrib><creatorcontrib>International Pediatric Stroke Study Group</creatorcontrib><creatorcontrib>the International Pediatric Stroke Study Group</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Felling, Ryan J.</au><au>Rafay, Mubeen F.</au><au>Bernard, Timothy J.</au><au>Carpenter, Jessica L.</au><au>Dlamini, Nomazulu</au><au>Hassanein, Sahar M. A.</au><au>Jordan, Lori C.</au><au>Noetzel, Michael J.</au><au>Rivkin, Michael J.</au><au>Shapiro, Kevin A.</au><au>Slim, Mahmoud</au><au>deVeber, Gabrielle</au><aucorp>International Pediatric Stroke Study Group</aucorp><aucorp>the International Pediatric Stroke Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predicting Recovery and Outcome after Pediatric Stroke: Results from the International Pediatric Stroke Study</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2020-06</date><risdate>2020</risdate><volume>87</volume><issue>6</issue><spage>840</spage><epage>852</epage><pages>840-852</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><abstract>Objective
To characterize predictors of recovery and outcome following pediatric arterial ischemic stroke, hypothesizing that age influences recovery after stroke.
Methods
We studied children enrolled in the International Pediatric Stroke Study between January 1, 2003 and July 31, 2014 with 2‐year follow‐up after arterial ischemic stroke. Outcomes were defined at discharge by clinician grading and at 2 years by the Pediatric Stroke Outcome Measure. Demographic, clinical, and radiologic outcome predictors were examined. We defined changes in outcome from discharge to 2 years as recovery (improved outcome), emerging deficit (worse outcome), or no change.
Results
Our population consisted of 587 patients, including 174 with neonatal stroke and 413 with childhood stroke, with recurrent stroke in 8.2% of childhood patients. Moderate to severe neurological impairment was present in 9.4% of neonates versus 48.8% of children at discharge compared to 8.0% versus 24.7% after 2 years. Predictors of poor outcome included age between 28 days and 1 year (compared to neonates, odds ratio [OR] = 3.58, p < 0.05), underlying chronic disorder (OR = 2.23, p < 0.05), and involvement of both small and large vascular territories (OR = 2.84, p < 0.05). Recovery patterns differed, with emerging deficits more common in children <1 year of age (p < 0.05).
Interpretation
Outcomes after pediatric stroke are generally favorable, but moderate to severe neurological impairments are still common. Age between 28 days and 1 year appears to be a particularly vulnerable period. Understanding the timing and predictors of recovery will allow us to better counsel families and target therapies to improve outcomes after pediatric stroke. ANN NEUROL 2020;87:840–852</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32215969</pmid><doi>10.1002/ana.25718</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-0191-8425</orcidid><orcidid>https://orcid.org/0000-0002-0845-9356</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-5134 |
| ispartof | Annals of neurology, 2020-06, Vol.87 (6), p.840-852 |
| issn | 0364-5134 1531-8249 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2384211051 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Age Children Discharge Ischemia Neonates Neurological complications Patients Pediatrics Recovery Stroke |
| title | Predicting Recovery and Outcome after Pediatric Stroke: Results from the International Pediatric Stroke Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T04%3A53%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Predicting%20Recovery%20and%20Outcome%20after%20Pediatric%20Stroke:%20Results%20from%20the%20International%20Pediatric%20Stroke%20Study&rft.jtitle=Annals%20of%20neurology&rft.au=Felling,%20Ryan%20J.&rft.aucorp=International%20Pediatric%20Stroke%20Study%20Group&rft.date=2020-06&rft.volume=87&rft.issue=6&rft.spage=840&rft.epage=852&rft.pages=840-852&rft.issn=0364-5134&rft.eissn=1531-8249&rft_id=info:doi/10.1002/ana.25718&rft_dat=%3Cproquest_cross%3E2405201161%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2405201161&rft_id=info:pmid/32215969&rfr_iscdi=true |