Characterization of the signature of peripheral innate immunity in women with later-life major depressive disorder
•The prevalence of later life depression (LLD) is higher in women than in men.•We examined sex difference in gene expression patterns in leukocytes of LLD patients.•The marked sex-difference was found in genes expressed in leukocytes of LLD patients.•Altered inflammatory activity may be involved in...
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2020-07, Vol.87, p.831-839 |
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| creator | Miyata, Shigeo Yamagata, Hirotaka Matsuo, Koji Uchida, Shusaku Harada, Kenichiro Fujihara, Kazuyuki Yanagawa, Yuchio Watanabe, Yoshifumi Mikuni, Masahiko Nakagawa, Shin Fukuda, Masato |
| description | •The prevalence of later life depression (LLD) is higher in women than in men.•We examined sex difference in gene expression patterns in leukocytes of LLD patients.•The marked sex-difference was found in genes expressed in leukocytes of LLD patients.•Altered inflammatory activity may be involved in the pathophysiology of LLD in women.•In contrast, abnormal inflammation may be an uncommon feature in LLD males.
The prevalence of depression in later life is higher in women than in men. However, the sex difference in the pathophysiology of depression in elderly patients is not fully understood. Here, we performed gene expression profiling in leukocytes of middle-aged and elderly patients with major depressive disorder, termed later-life depression (LLD) in this context, and we characterized the sex-dependent pathophysiology of LLD.
A microarray dataset obtained from leukocytes of patients (aged ≥50 years) with LLD (32 males and 39 females) and age-matched healthy individuals (20 males and 24 females) was used. Differentially expressed probes were determined by comparing the expression levels between patients and healthy individuals, and then functional annotation analyses (Ingenuity Pathway Analysis, Reactome pathway analysis, and cell-type enrichment analysis) were performed.
A total of 1656 probes were differentially expressed in LLD females, but only 3 genes were differentially expressed in LLD males. The differentially expressed genes in LLD females were relevant to leukocyte extravasation signaling, Tec kinase signaling and the innate immune response. The upregulated genes were relevant to myeloid lineage cells such as CD14+ monocytes. In contrast, the downregulated genes were relevant to CD4+ and CD8+ T cells.
Remarkable innate immune signatures are present in the leukocytes of LLD females but not males. Because inflammation is involved in the pathophysiology of depression, the altered inflammatory activity may be involved in the pathophysiology of LLD in women. In contrast, abnormal inflammation may be an uncommon feature in LLD males. |
| doi_str_mv | 10.1016/j.bbi.2020.03.018 |
| format | Article |
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The prevalence of depression in later life is higher in women than in men. However, the sex difference in the pathophysiology of depression in elderly patients is not fully understood. Here, we performed gene expression profiling in leukocytes of middle-aged and elderly patients with major depressive disorder, termed later-life depression (LLD) in this context, and we characterized the sex-dependent pathophysiology of LLD.
A microarray dataset obtained from leukocytes of patients (aged ≥50 years) with LLD (32 males and 39 females) and age-matched healthy individuals (20 males and 24 females) was used. Differentially expressed probes were determined by comparing the expression levels between patients and healthy individuals, and then functional annotation analyses (Ingenuity Pathway Analysis, Reactome pathway analysis, and cell-type enrichment analysis) were performed.
A total of 1656 probes were differentially expressed in LLD females, but only 3 genes were differentially expressed in LLD males. The differentially expressed genes in LLD females were relevant to leukocyte extravasation signaling, Tec kinase signaling and the innate immune response. The upregulated genes were relevant to myeloid lineage cells such as CD14+ monocytes. In contrast, the downregulated genes were relevant to CD4+ and CD8+ T cells.
Remarkable innate immune signatures are present in the leukocytes of LLD females but not males. Because inflammation is involved in the pathophysiology of depression, the altered inflammatory activity may be involved in the pathophysiology of LLD in women. In contrast, abnormal inflammation may be an uncommon feature in LLD males.</description><identifier>ISSN: 0889-1591</identifier><identifier>EISSN: 1090-2139</identifier><identifier>DOI: 10.1016/j.bbi.2020.03.018</identifier><identifier>PMID: 32217081</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Aged ; Blood ; CD8-Positive T-Lymphocytes ; Depressive Disorder, Major - genetics ; Elderly ; Female ; Gene Expression Profiling ; Humans ; Immune system ; Immunity, Innate ; Major depressive disorder ; Male ; Microarray ; Microarray Analysis ; Middle Aged ; Sex difference</subject><ispartof>Brain, behavior, and immunity, 2020-07, Vol.87, p.831-839</ispartof><rights>2020 The Authors</rights><rights>Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-b008be923b8bef5f8bc411672f4db4d7931f8d1b56d5ecc65424fce2ec114fe43</citedby><cites>FETCH-LOGICAL-c396t-b008be923b8bef5f8bc411672f4db4d7931f8d1b56d5ecc65424fce2ec114fe43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbi.2020.03.018$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32217081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyata, Shigeo</creatorcontrib><creatorcontrib>Yamagata, Hirotaka</creatorcontrib><creatorcontrib>Matsuo, Koji</creatorcontrib><creatorcontrib>Uchida, Shusaku</creatorcontrib><creatorcontrib>Harada, Kenichiro</creatorcontrib><creatorcontrib>Fujihara, Kazuyuki</creatorcontrib><creatorcontrib>Yanagawa, Yuchio</creatorcontrib><creatorcontrib>Watanabe, Yoshifumi</creatorcontrib><creatorcontrib>Mikuni, Masahiko</creatorcontrib><creatorcontrib>Nakagawa, Shin</creatorcontrib><creatorcontrib>Fukuda, Masato</creatorcontrib><title>Characterization of the signature of peripheral innate immunity in women with later-life major depressive disorder</title><title>Brain, behavior, and immunity</title><addtitle>Brain Behav Immun</addtitle><description>•The prevalence of later life depression (LLD) is higher in women than in men.•We examined sex difference in gene expression patterns in leukocytes of LLD patients.•The marked sex-difference was found in genes expressed in leukocytes of LLD patients.•Altered inflammatory activity may be involved in the pathophysiology of LLD in women.•In contrast, abnormal inflammation may be an uncommon feature in LLD males.
The prevalence of depression in later life is higher in women than in men. However, the sex difference in the pathophysiology of depression in elderly patients is not fully understood. Here, we performed gene expression profiling in leukocytes of middle-aged and elderly patients with major depressive disorder, termed later-life depression (LLD) in this context, and we characterized the sex-dependent pathophysiology of LLD.
A microarray dataset obtained from leukocytes of patients (aged ≥50 years) with LLD (32 males and 39 females) and age-matched healthy individuals (20 males and 24 females) was used. Differentially expressed probes were determined by comparing the expression levels between patients and healthy individuals, and then functional annotation analyses (Ingenuity Pathway Analysis, Reactome pathway analysis, and cell-type enrichment analysis) were performed.
A total of 1656 probes were differentially expressed in LLD females, but only 3 genes were differentially expressed in LLD males. The differentially expressed genes in LLD females were relevant to leukocyte extravasation signaling, Tec kinase signaling and the innate immune response. The upregulated genes were relevant to myeloid lineage cells such as CD14+ monocytes. In contrast, the downregulated genes were relevant to CD4+ and CD8+ T cells.
Remarkable innate immune signatures are present in the leukocytes of LLD females but not males. Because inflammation is involved in the pathophysiology of depression, the altered inflammatory activity may be involved in the pathophysiology of LLD in women. In contrast, abnormal inflammation may be an uncommon feature in LLD males.</description><subject>Aged</subject><subject>Blood</subject><subject>CD8-Positive T-Lymphocytes</subject><subject>Depressive Disorder, Major - genetics</subject><subject>Elderly</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity, Innate</subject><subject>Major depressive disorder</subject><subject>Male</subject><subject>Microarray</subject><subject>Microarray Analysis</subject><subject>Middle Aged</subject><subject>Sex difference</subject><issn>0889-1591</issn><issn>1090-2139</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9v1DAQxS0EotvCB-CCfOSS4LGTrCNOaFUoUiUucLb8Z8x6lcTBdorKp8erLRy5zNPMvHnS_Ah5A6wFBsP7U2tMaDnjrGWiZSCfkR2wkTUcxPic7JiUYwP9CFfkOucTY6wXIF-SK8E57JmEHUmHo07aFkzhty4hLjR6Wo5Ic_ix6LIlPA_Wul6PmPREw1LHSMM8b0soj7Wnv-KMtYZypFPdpWYKHumsTzFRh2vCnMMDUhdyTA7TK_LC6ynj6ye9Id8_3X473DX3Xz9_OXy8b6wYh9IYxqTBkQtTxfdeGtsBDHvuO2c6tx8FeOnA9IPr0dqh73jnLXK0AJ3HTtyQd5fcNcWfG-ai5pAtTpNeMG5ZcSE7DmdG1QoXq00x54RerSnMOj0qYOqMWp1URa3OqBUTqqKuN2-f4jczo_t38ZdtNXy4GLA--RAwqWwDLhZdSGiLcjH8J_4PveqRgw</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Miyata, Shigeo</creator><creator>Yamagata, Hirotaka</creator><creator>Matsuo, Koji</creator><creator>Uchida, Shusaku</creator><creator>Harada, Kenichiro</creator><creator>Fujihara, Kazuyuki</creator><creator>Yanagawa, Yuchio</creator><creator>Watanabe, Yoshifumi</creator><creator>Mikuni, Masahiko</creator><creator>Nakagawa, Shin</creator><creator>Fukuda, Masato</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202007</creationdate><title>Characterization of the signature of peripheral innate immunity in women with later-life major depressive disorder</title><author>Miyata, Shigeo ; Yamagata, Hirotaka ; Matsuo, Koji ; Uchida, Shusaku ; Harada, Kenichiro ; Fujihara, Kazuyuki ; Yanagawa, Yuchio ; Watanabe, Yoshifumi ; Mikuni, Masahiko ; Nakagawa, Shin ; Fukuda, Masato</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-b008be923b8bef5f8bc411672f4db4d7931f8d1b56d5ecc65424fce2ec114fe43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Blood</topic><topic>CD8-Positive T-Lymphocytes</topic><topic>Depressive Disorder, Major - genetics</topic><topic>Elderly</topic><topic>Female</topic><topic>Gene Expression Profiling</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunity, Innate</topic><topic>Major depressive disorder</topic><topic>Male</topic><topic>Microarray</topic><topic>Microarray Analysis</topic><topic>Middle Aged</topic><topic>Sex difference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyata, Shigeo</creatorcontrib><creatorcontrib>Yamagata, Hirotaka</creatorcontrib><creatorcontrib>Matsuo, Koji</creatorcontrib><creatorcontrib>Uchida, Shusaku</creatorcontrib><creatorcontrib>Harada, Kenichiro</creatorcontrib><creatorcontrib>Fujihara, Kazuyuki</creatorcontrib><creatorcontrib>Yanagawa, Yuchio</creatorcontrib><creatorcontrib>Watanabe, Yoshifumi</creatorcontrib><creatorcontrib>Mikuni, Masahiko</creatorcontrib><creatorcontrib>Nakagawa, Shin</creatorcontrib><creatorcontrib>Fukuda, Masato</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain, behavior, and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyata, Shigeo</au><au>Yamagata, Hirotaka</au><au>Matsuo, Koji</au><au>Uchida, Shusaku</au><au>Harada, Kenichiro</au><au>Fujihara, Kazuyuki</au><au>Yanagawa, Yuchio</au><au>Watanabe, Yoshifumi</au><au>Mikuni, Masahiko</au><au>Nakagawa, Shin</au><au>Fukuda, Masato</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of the signature of peripheral innate immunity in women with later-life major depressive disorder</atitle><jtitle>Brain, behavior, and immunity</jtitle><addtitle>Brain Behav Immun</addtitle><date>2020-07</date><risdate>2020</risdate><volume>87</volume><spage>831</spage><epage>839</epage><pages>831-839</pages><issn>0889-1591</issn><eissn>1090-2139</eissn><abstract>•The prevalence of later life depression (LLD) is higher in women than in men.•We examined sex difference in gene expression patterns in leukocytes of LLD patients.•The marked sex-difference was found in genes expressed in leukocytes of LLD patients.•Altered inflammatory activity may be involved in the pathophysiology of LLD in women.•In contrast, abnormal inflammation may be an uncommon feature in LLD males.
The prevalence of depression in later life is higher in women than in men. However, the sex difference in the pathophysiology of depression in elderly patients is not fully understood. Here, we performed gene expression profiling in leukocytes of middle-aged and elderly patients with major depressive disorder, termed later-life depression (LLD) in this context, and we characterized the sex-dependent pathophysiology of LLD.
A microarray dataset obtained from leukocytes of patients (aged ≥50 years) with LLD (32 males and 39 females) and age-matched healthy individuals (20 males and 24 females) was used. Differentially expressed probes were determined by comparing the expression levels between patients and healthy individuals, and then functional annotation analyses (Ingenuity Pathway Analysis, Reactome pathway analysis, and cell-type enrichment analysis) were performed.
A total of 1656 probes were differentially expressed in LLD females, but only 3 genes were differentially expressed in LLD males. The differentially expressed genes in LLD females were relevant to leukocyte extravasation signaling, Tec kinase signaling and the innate immune response. The upregulated genes were relevant to myeloid lineage cells such as CD14+ monocytes. In contrast, the downregulated genes were relevant to CD4+ and CD8+ T cells.
Remarkable innate immune signatures are present in the leukocytes of LLD females but not males. Because inflammation is involved in the pathophysiology of depression, the altered inflammatory activity may be involved in the pathophysiology of LLD in women. In contrast, abnormal inflammation may be an uncommon feature in LLD males.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>32217081</pmid><doi>10.1016/j.bbi.2020.03.018</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Blood CD8-Positive T-Lymphocytes Depressive Disorder, Major - genetics Elderly Female Gene Expression Profiling Humans Immune system Immunity, Innate Major depressive disorder Male Microarray Microarray Analysis Middle Aged Sex difference |
| title | Characterization of the signature of peripheral innate immunity in women with later-life major depressive disorder |
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