Development of Prostate Cancer Organoid Culture Models in Basic Medicine and Translational Research
Prostate cancer (PC) is the most prevalent cancer in men and the second main cause of cancer-related death in Western society. The lack of proper PC models that recapitulate the molecular and genomic landscape of clinical disease has hampered progress toward translational research to understand the...
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| Veröffentlicht in: | Cancers 2020-03, Vol.12 (4), p.777, Article 777 |
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| creator | Elbadawy, Mohamed Abugomaa, Amira Yamawaki, Hideyuki Usui, Tatsuya Sasaki, Kazuaki |
| description | Prostate cancer (PC) is the most prevalent cancer in men and the second main cause of cancer-related death in Western society. The lack of proper PC models that recapitulate the molecular and genomic landscape of clinical disease has hampered progress toward translational research to understand the disease initiation, progression, and therapeutic responses in each patient. Although several models have been developed, they hardly emulated the complicated PC microenvironment. Precision medicine is an emerging approach predicting appropriate therapies for individual cancer patients by means of various analyses of individual genomic profiling and targeting specific cancer pathways. In PC, precision medicine also has the potential to impose changes in clinical practices. Here, we describe the various PC models with special focus on PC organoids and their values in basic medicine, personalized therapy, and translational researches in vitro and in vivo, which could help to achieve the full transformative power of cancer precision medicine. |
| doi_str_mv | 10.3390/cancers12040777 |
| format | Article |
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The lack of proper PC models that recapitulate the molecular and genomic landscape of clinical disease has hampered progress toward translational research to understand the disease initiation, progression, and therapeutic responses in each patient. Although several models have been developed, they hardly emulated the complicated PC microenvironment. Precision medicine is an emerging approach predicting appropriate therapies for individual cancer patients by means of various analyses of individual genomic profiling and targeting specific cancer pathways. In PC, precision medicine also has the potential to impose changes in clinical practices. Here, we describe the various PC models with special focus on PC organoids and their values in basic medicine, personalized therapy, and translational researches in vitro and in vivo, which could help to achieve the full transformative power of cancer precision medicine.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers12040777</identifier><identifier>PMID: 32218271</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Androgens ; Cancer therapies ; Cell cycle ; Chemotherapy ; Disease ; Immunotherapy ; Kinases ; Life Sciences & Biomedicine ; Medical research ; Metastasis ; Molecular modelling ; Mutation ; Oncology ; Organoids ; Patients ; Precision medicine ; Prostate cancer ; Proteins ; Radiation therapy ; Researchers ; Review ; Science & Technology ; Signal transduction ; Translation ; Tumorigenesis</subject><ispartof>Cancers, 2020-03, Vol.12 (4), p.777, Article 777</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>35</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000535587400007</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c487t-b8bd05d717c7f06b49b219cecfb6d9b28486009e4aabfc55fde3c36b1195c0493</citedby><cites>FETCH-LOGICAL-c487t-b8bd05d717c7f06b49b219cecfb6d9b28486009e4aabfc55fde3c36b1195c0493</cites><orcidid>0000-0002-1818-2127 ; 0000-0001-9368-1535 ; 0000-0002-8259-8258</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226333/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226333/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,28253,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32218271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elbadawy, Mohamed</creatorcontrib><creatorcontrib>Abugomaa, Amira</creatorcontrib><creatorcontrib>Yamawaki, Hideyuki</creatorcontrib><creatorcontrib>Usui, Tatsuya</creatorcontrib><creatorcontrib>Sasaki, Kazuaki</creatorcontrib><title>Development of Prostate Cancer Organoid Culture Models in Basic Medicine and Translational Research</title><title>Cancers</title><addtitle>CANCERS</addtitle><addtitle>Cancers (Basel)</addtitle><description>Prostate cancer (PC) is the most prevalent cancer in men and the second main cause of cancer-related death in Western society. The lack of proper PC models that recapitulate the molecular and genomic landscape of clinical disease has hampered progress toward translational research to understand the disease initiation, progression, and therapeutic responses in each patient. Although several models have been developed, they hardly emulated the complicated PC microenvironment. Precision medicine is an emerging approach predicting appropriate therapies for individual cancer patients by means of various analyses of individual genomic profiling and targeting specific cancer pathways. In PC, precision medicine also has the potential to impose changes in clinical practices. Here, we describe the various PC models with special focus on PC organoids and their values in basic medicine, personalized therapy, and translational researches in vitro and in vivo, which could help to achieve the full transformative power of cancer precision medicine.</description><subject>Androgens</subject><subject>Cancer therapies</subject><subject>Cell cycle</subject><subject>Chemotherapy</subject><subject>Disease</subject><subject>Immunotherapy</subject><subject>Kinases</subject><subject>Life Sciences & Biomedicine</subject><subject>Medical research</subject><subject>Metastasis</subject><subject>Molecular modelling</subject><subject>Mutation</subject><subject>Oncology</subject><subject>Organoids</subject><subject>Patients</subject><subject>Precision medicine</subject><subject>Prostate cancer</subject><subject>Proteins</subject><subject>Radiation therapy</subject><subject>Researchers</subject><subject>Review</subject><subject>Science & Technology</subject><subject>Signal transduction</subject><subject>Translation</subject><subject>Tumorigenesis</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkctLHTEUxkNpqXLrursS6KZQbs1jJpnZFNrpQ0GxFLse8jijkdzkNslY_O_N9dqLuvJsciC_7zs5-RB6S8knzntyaFQwkDJlpCFSyhdonxHJlkL0zcsH_R46yPmK1OKcSiFfoz3OGO2YpPvIfINr8HG9glBwnPCvFHNRBfBwZ47P0oUK0Vk8zL7MCfBptOAzdgF_VdkZfArWGRcAq2DxeVIhe1VcDMrj35BBJXP5Br2alM9wcH8u0J8f38-Ho-XJ2c_j4cvJ0jSdLEvdaUtaK6k0ciJCN71mtDdgJi1s7bumE4T00CilJ9O2kwVuuNCU9q0hTc8X6PPWdz3rFVhTV0rKj-vkVirdjFG58fFNcJfjRbweJWOC11qgD_cGKf6dIZdx5bIB71WAOOeR8a5hhLN-M-v9E_QqzqluvaU4EbxnlTrcUqZ-a04w7R5DybjJcHySYVW8e7jDjv-fWAW6LfAPdJyycVANdlgNueVt28lmk7ccXLkLY4hzKFX68flSfgusTbrc</recordid><startdate>20200325</startdate><enddate>20200325</enddate><creator>Elbadawy, Mohamed</creator><creator>Abugomaa, Amira</creator><creator>Yamawaki, Hideyuki</creator><creator>Usui, Tatsuya</creator><creator>Sasaki, Kazuaki</creator><general>Mdpi</general><general>MDPI AG</general><general>MDPI</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1818-2127</orcidid><orcidid>https://orcid.org/0000-0001-9368-1535</orcidid><orcidid>https://orcid.org/0000-0002-8259-8258</orcidid></search><sort><creationdate>20200325</creationdate><title>Development of Prostate Cancer Organoid Culture Models in Basic Medicine and Translational Research</title><author>Elbadawy, Mohamed ; 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| subjects | Androgens Cancer therapies Cell cycle Chemotherapy Disease Immunotherapy Kinases Life Sciences & Biomedicine Medical research Metastasis Molecular modelling Mutation Oncology Organoids Patients Precision medicine Prostate cancer Proteins Radiation therapy Researchers Review Science & Technology Signal transduction Translation Tumorigenesis |
| title | Development of Prostate Cancer Organoid Culture Models in Basic Medicine and Translational Research |
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