Effect of mobile phone radiation on oxidative stress, inflammatory response, and contextual fear memory in Wistar rat
In the present lifestyle, we are continuously exposed to radiofrequency electromagnetic field (RF-EMF) radiation generated mainly by mobile phones (MP). Among other organs, our brain and hippocampus in specific, is the region where effect of any environmental perturbation is most pronounced. So, thi...
Gespeichert in:
| Veröffentlicht in: | Environmental science and pollution research international 2020-06, Vol.27 (16), p.19340-19351 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 19351 |
|---|---|
| container_issue | 16 |
| container_start_page | 19340 |
| container_title | Environmental science and pollution research international |
| container_volume | 27 |
| creator | Singh, Kumari Vandana Gautam, Rohit Meena, Ramovtar Nirala, Jay Prakash Jha, Sushil Kumar Rajamani, Paulraj |
| description | In the present lifestyle, we are continuously exposed to radiofrequency electromagnetic field (RF-EMF) radiation generated mainly by mobile phones (MP). Among other organs, our brain and hippocampus in specific, is the region where effect of any environmental perturbation is most pronounced. So, this study was aimed to examine changes in major parameters (oxidative stress, level of pro-inflammatory cytokines (PICs), hypothalamic-pituitary-adrenal (HPA) axis hormones, and contextual fear conditioning) which are linked to hippocampus directly or indirectly, upon exposure to mobile phone radiofrequency electromagnetic field (MP-RF-EMF) radiation. Exposure was performed on young adult male Wistar rats for 16 weeks continuously (2 h/day) with MP-RF-EMF radiation having frequency, power density, and specific absorption rate (SAR) of 1966.1 MHz, 4.0 mW/cm
2
, and 0.36 W/kg, respectively. Another set of animals kept in similar conditions without any radiation exposure serves as control. Towards the end of exposure period, animals were tested for fear memory and then euthanized to measure hippocampal oxidative stress, level of circulatory PICs, and stress hormones. We observed significant increase in hippocampal oxidative stress (
p
|
| doi_str_mv | 10.1007/s11356-020-07916-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2383525203</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2405803245</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-1809e1b6b717b90cc52da633edcf009e3e128e71c6ca255d35ed7aca482ee193</originalsourceid><addsrcrecordid>eNp9kU9rFTEUxYMo9ln9Ai4k4KaLjubmz2RmWR6tCgU3BZchk7nTpswkzyQjbT9983xVoQshEHLu7557ySHkPbBPwJj-nAGEahvGWcN0D23z8IJsoAXZaNn3L8mG9VI2IKQ8Im9yvmWV7Ll-TY4E58CZhg1Zz6cJXaFxoksc_Ix0dxMD0mRHb4uPge7PnR_r4xfSXBLmfEp9mGa7LLbEdE-rtIsh4ym1YaQuhoJ3ZbUzndAmuuCyh3ygP3wuVUi2vCWvJjtnfPd0H5Ori_Or7dfm8vuXb9uzy8ZJ4KWBjvUIQzto0EPPnFN8tK0QOLqJ1ZJA4B1qcK2zXKlRKBy1dVZ2HBF6cUxODra7FH-umItZfHY4zzZgXLPhohOKK85ERT8-Q2_jmkJdznDJVMcEl6pS_EC5FHNOOJld8otN9waY2WdiDpmY-tPmdybmoTZ9eLJehwXHvy1_QqiAOAC5lsI1pn-z_2P7CIaLmPc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2405803245</pqid></control><display><type>article</type><title>Effect of mobile phone radiation on oxidative stress, inflammatory response, and contextual fear memory in Wistar rat</title><source>SpringerLink (Online service)</source><creator>Singh, Kumari Vandana ; Gautam, Rohit ; Meena, Ramovtar ; Nirala, Jay Prakash ; Jha, Sushil Kumar ; Rajamani, Paulraj</creator><creatorcontrib>Singh, Kumari Vandana ; Gautam, Rohit ; Meena, Ramovtar ; Nirala, Jay Prakash ; Jha, Sushil Kumar ; Rajamani, Paulraj</creatorcontrib><description><![CDATA[In the present lifestyle, we are continuously exposed to radiofrequency electromagnetic field (RF-EMF) radiation generated mainly by mobile phones (MP). Among other organs, our brain and hippocampus in specific, is the region where effect of any environmental perturbation is most pronounced. So, this study was aimed to examine changes in major parameters (oxidative stress, level of pro-inflammatory cytokines (PICs), hypothalamic-pituitary-adrenal (HPA) axis hormones, and contextual fear conditioning) which are linked to hippocampus directly or indirectly, upon exposure to mobile phone radiofrequency electromagnetic field (MP-RF-EMF) radiation. Exposure was performed on young adult male Wistar rats for 16 weeks continuously (2 h/day) with MP-RF-EMF radiation having frequency, power density, and specific absorption rate (SAR) of 1966.1 MHz, 4.0 mW/cm
2
, and 0.36 W/kg, respectively. Another set of animals kept in similar conditions without any radiation exposure serves as control. Towards the end of exposure period, animals were tested for fear memory and then euthanized to measure hippocampal oxidative stress, level of circulatory PICs, and stress hormones. We observed significant increase in hippocampal oxidative stress (
p
< 0.05) and elevated level of circulatory PICs viz. IL-1beta (
p
< 0.01), IL-6 (
p
< 0.05), and TNF-alpha (
p
< 0.001) in experimental animals upon exposure to MP-RF-EMF radiation. Adrenal gland weight (
p
< 0.001) and level of stress hormones viz. adrenocorticotropic hormone (ACTH) (
p
< 0.01) and corticosterone (CORT) (
p
< 0.05) were also found to increase significantly in MP-RF-EMF radiation-exposed animals as compared with control. However, alteration in contextual fear memory was not significant enough. In conclusion, current study shows that chronic exposure to MP-RF-EMF radiation emitted from mobile phones may induce oxidative stress, inflammatory response, and HPA axis deregulation. However, changes in hippocampal functionality depend on the complex interplay of several opposing factors that got affected upon MP-RF-EMF exposure.]]></description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-020-07916-z</identifier><identifier>PMID: 32212071</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adrenal glands ; Adrenocorticotropic hormone ; Alpha rays ; Animals ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Cell phones ; Cellular telephones ; Chronic exposure ; Corticosterone ; Cytokines ; Deregulation ; Earth and Environmental Science ; Ecotoxicology ; Electromagnetic fields ; Electromagnetic radiation ; Electromagnetism ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Fear ; Fear conditioning ; Hippocampus ; Hormones ; Hypothalamic-pituitary-adrenal axis ; Hypothalamus ; IL-1β ; Inflammation ; Inflammatory response ; Interleukin 1 ; Interleukin 6 ; Low frequency ; Organs ; Oxidative stress ; Perturbation ; Pituitary ; Radiation ; Radiation effects ; Radio frequency ; Research Article ; Tumor necrosis factor ; Waste Water Technology ; Water Management ; Water Pollution Control ; Young adults</subject><ispartof>Environmental science and pollution research international, 2020-06, Vol.27 (16), p.19340-19351</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-1809e1b6b717b90cc52da633edcf009e3e128e71c6ca255d35ed7aca482ee193</citedby><cites>FETCH-LOGICAL-c412t-1809e1b6b717b90cc52da633edcf009e3e128e71c6ca255d35ed7aca482ee193</cites><orcidid>0000-0003-4922-9028</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-020-07916-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-020-07916-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32212071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Kumari Vandana</creatorcontrib><creatorcontrib>Gautam, Rohit</creatorcontrib><creatorcontrib>Meena, Ramovtar</creatorcontrib><creatorcontrib>Nirala, Jay Prakash</creatorcontrib><creatorcontrib>Jha, Sushil Kumar</creatorcontrib><creatorcontrib>Rajamani, Paulraj</creatorcontrib><title>Effect of mobile phone radiation on oxidative stress, inflammatory response, and contextual fear memory in Wistar rat</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description><![CDATA[In the present lifestyle, we are continuously exposed to radiofrequency electromagnetic field (RF-EMF) radiation generated mainly by mobile phones (MP). Among other organs, our brain and hippocampus in specific, is the region where effect of any environmental perturbation is most pronounced. So, this study was aimed to examine changes in major parameters (oxidative stress, level of pro-inflammatory cytokines (PICs), hypothalamic-pituitary-adrenal (HPA) axis hormones, and contextual fear conditioning) which are linked to hippocampus directly or indirectly, upon exposure to mobile phone radiofrequency electromagnetic field (MP-RF-EMF) radiation. Exposure was performed on young adult male Wistar rats for 16 weeks continuously (2 h/day) with MP-RF-EMF radiation having frequency, power density, and specific absorption rate (SAR) of 1966.1 MHz, 4.0 mW/cm
2
, and 0.36 W/kg, respectively. Another set of animals kept in similar conditions without any radiation exposure serves as control. Towards the end of exposure period, animals were tested for fear memory and then euthanized to measure hippocampal oxidative stress, level of circulatory PICs, and stress hormones. We observed significant increase in hippocampal oxidative stress (
p
< 0.05) and elevated level of circulatory PICs viz. IL-1beta (
p
< 0.01), IL-6 (
p
< 0.05), and TNF-alpha (
p
< 0.001) in experimental animals upon exposure to MP-RF-EMF radiation. Adrenal gland weight (
p
< 0.001) and level of stress hormones viz. adrenocorticotropic hormone (ACTH) (
p
< 0.01) and corticosterone (CORT) (
p
< 0.05) were also found to increase significantly in MP-RF-EMF radiation-exposed animals as compared with control. However, alteration in contextual fear memory was not significant enough. In conclusion, current study shows that chronic exposure to MP-RF-EMF radiation emitted from mobile phones may induce oxidative stress, inflammatory response, and HPA axis deregulation. However, changes in hippocampal functionality depend on the complex interplay of several opposing factors that got affected upon MP-RF-EMF exposure.]]></description><subject>Adrenal glands</subject><subject>Adrenocorticotropic hormone</subject><subject>Alpha rays</subject><subject>Animals</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Cell phones</subject><subject>Cellular telephones</subject><subject>Chronic exposure</subject><subject>Corticosterone</subject><subject>Cytokines</subject><subject>Deregulation</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Electromagnetic fields</subject><subject>Electromagnetic radiation</subject><subject>Electromagnetism</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Fear</subject><subject>Fear conditioning</subject><subject>Hippocampus</subject><subject>Hormones</subject><subject>Hypothalamic-pituitary-adrenal axis</subject><subject>Hypothalamus</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Interleukin 1</subject><subject>Interleukin 6</subject><subject>Low frequency</subject><subject>Organs</subject><subject>Oxidative stress</subject><subject>Perturbation</subject><subject>Pituitary</subject><subject>Radiation</subject><subject>Radiation effects</subject><subject>Radio frequency</subject><subject>Research Article</subject><subject>Tumor necrosis factor</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><subject>Young adults</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9rFTEUxYMo9ln9Ai4k4KaLjubmz2RmWR6tCgU3BZchk7nTpswkzyQjbT9983xVoQshEHLu7557ySHkPbBPwJj-nAGEahvGWcN0D23z8IJsoAXZaNn3L8mG9VI2IKQ8Im9yvmWV7Ll-TY4E58CZhg1Zz6cJXaFxoksc_Ix0dxMD0mRHb4uPge7PnR_r4xfSXBLmfEp9mGa7LLbEdE-rtIsh4ym1YaQuhoJ3ZbUzndAmuuCyh3ygP3wuVUi2vCWvJjtnfPd0H5Ori_Or7dfm8vuXb9uzy8ZJ4KWBjvUIQzto0EPPnFN8tK0QOLqJ1ZJA4B1qcK2zXKlRKBy1dVZ2HBF6cUxODra7FH-umItZfHY4zzZgXLPhohOKK85ERT8-Q2_jmkJdznDJVMcEl6pS_EC5FHNOOJld8otN9waY2WdiDpmY-tPmdybmoTZ9eLJehwXHvy1_QqiAOAC5lsI1pn-z_2P7CIaLmPc</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Singh, Kumari Vandana</creator><creator>Gautam, Rohit</creator><creator>Meena, Ramovtar</creator><creator>Nirala, Jay Prakash</creator><creator>Jha, Sushil Kumar</creator><creator>Rajamani, Paulraj</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4922-9028</orcidid></search><sort><creationdate>20200601</creationdate><title>Effect of mobile phone radiation on oxidative stress, inflammatory response, and contextual fear memory in Wistar rat</title><author>Singh, Kumari Vandana ; Gautam, Rohit ; Meena, Ramovtar ; Nirala, Jay Prakash ; Jha, Sushil Kumar ; Rajamani, Paulraj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-1809e1b6b717b90cc52da633edcf009e3e128e71c6ca255d35ed7aca482ee193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adrenal glands</topic><topic>Adrenocorticotropic hormone</topic><topic>Alpha rays</topic><topic>Animals</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Cell phones</topic><topic>Cellular telephones</topic><topic>Chronic exposure</topic><topic>Corticosterone</topic><topic>Cytokines</topic><topic>Deregulation</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Electromagnetic fields</topic><topic>Electromagnetic radiation</topic><topic>Electromagnetism</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental science</topic><topic>Fear</topic><topic>Fear conditioning</topic><topic>Hippocampus</topic><topic>Hormones</topic><topic>Hypothalamic-pituitary-adrenal axis</topic><topic>Hypothalamus</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Interleukin 1</topic><topic>Interleukin 6</topic><topic>Low frequency</topic><topic>Organs</topic><topic>Oxidative stress</topic><topic>Perturbation</topic><topic>Pituitary</topic><topic>Radiation</topic><topic>Radiation effects</topic><topic>Radio frequency</topic><topic>Research Article</topic><topic>Tumor necrosis factor</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Kumari Vandana</creatorcontrib><creatorcontrib>Gautam, Rohit</creatorcontrib><creatorcontrib>Meena, Ramovtar</creatorcontrib><creatorcontrib>Nirala, Jay Prakash</creatorcontrib><creatorcontrib>Jha, Sushil Kumar</creatorcontrib><creatorcontrib>Rajamani, Paulraj</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>PHMC-Proquest健康医学期刊库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>One Business (ProQuest)</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Kumari Vandana</au><au>Gautam, Rohit</au><au>Meena, Ramovtar</au><au>Nirala, Jay Prakash</au><au>Jha, Sushil Kumar</au><au>Rajamani, Paulraj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of mobile phone radiation on oxidative stress, inflammatory response, and contextual fear memory in Wistar rat</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>27</volume><issue>16</issue><spage>19340</spage><epage>19351</epage><pages>19340-19351</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract><![CDATA[In the present lifestyle, we are continuously exposed to radiofrequency electromagnetic field (RF-EMF) radiation generated mainly by mobile phones (MP). Among other organs, our brain and hippocampus in specific, is the region where effect of any environmental perturbation is most pronounced. So, this study was aimed to examine changes in major parameters (oxidative stress, level of pro-inflammatory cytokines (PICs), hypothalamic-pituitary-adrenal (HPA) axis hormones, and contextual fear conditioning) which are linked to hippocampus directly or indirectly, upon exposure to mobile phone radiofrequency electromagnetic field (MP-RF-EMF) radiation. Exposure was performed on young adult male Wistar rats for 16 weeks continuously (2 h/day) with MP-RF-EMF radiation having frequency, power density, and specific absorption rate (SAR) of 1966.1 MHz, 4.0 mW/cm
2
, and 0.36 W/kg, respectively. Another set of animals kept in similar conditions without any radiation exposure serves as control. Towards the end of exposure period, animals were tested for fear memory and then euthanized to measure hippocampal oxidative stress, level of circulatory PICs, and stress hormones. We observed significant increase in hippocampal oxidative stress (
p
< 0.05) and elevated level of circulatory PICs viz. IL-1beta (
p
< 0.01), IL-6 (
p
< 0.05), and TNF-alpha (
p
< 0.001) in experimental animals upon exposure to MP-RF-EMF radiation. Adrenal gland weight (
p
< 0.001) and level of stress hormones viz. adrenocorticotropic hormone (ACTH) (
p
< 0.01) and corticosterone (CORT) (
p
< 0.05) were also found to increase significantly in MP-RF-EMF radiation-exposed animals as compared with control. However, alteration in contextual fear memory was not significant enough. In conclusion, current study shows that chronic exposure to MP-RF-EMF radiation emitted from mobile phones may induce oxidative stress, inflammatory response, and HPA axis deregulation. However, changes in hippocampal functionality depend on the complex interplay of several opposing factors that got affected upon MP-RF-EMF exposure.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32212071</pmid><doi>10.1007/s11356-020-07916-z</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-4922-9028</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2020-06, Vol.27 (16), p.19340-19351 |
| issn | 0944-1344 1614-7499 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2383525203 |
| source | SpringerLink (Online service) |
| subjects | Adrenal glands Adrenocorticotropic hormone Alpha rays Animals Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Cell phones Cellular telephones Chronic exposure Corticosterone Cytokines Deregulation Earth and Environmental Science Ecotoxicology Electromagnetic fields Electromagnetic radiation Electromagnetism Environment Environmental Chemistry Environmental Health Environmental science Fear Fear conditioning Hippocampus Hormones Hypothalamic-pituitary-adrenal axis Hypothalamus IL-1β Inflammation Inflammatory response Interleukin 1 Interleukin 6 Low frequency Organs Oxidative stress Perturbation Pituitary Radiation Radiation effects Radio frequency Research Article Tumor necrosis factor Waste Water Technology Water Management Water Pollution Control Young adults |
| title | Effect of mobile phone radiation on oxidative stress, inflammatory response, and contextual fear memory in Wistar rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T10%3A44%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20mobile%20phone%20radiation%20on%20oxidative%20stress,%20inflammatory%20response,%20and%20contextual%20fear%20memory%20in%20Wistar%20rat&rft.jtitle=Environmental%20science%20and%20pollution%20research%20international&rft.au=Singh,%20Kumari%20Vandana&rft.date=2020-06-01&rft.volume=27&rft.issue=16&rft.spage=19340&rft.epage=19351&rft.pages=19340-19351&rft.issn=0944-1344&rft.eissn=1614-7499&rft_id=info:doi/10.1007/s11356-020-07916-z&rft_dat=%3Cproquest_cross%3E2405803245%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2405803245&rft_id=info:pmid/32212071&rfr_iscdi=true |