Chiral Carbon Dots Mimicking Topoisomerase I To Mediate the Topological Rearrangement of Supercoiled DNA Enantioselectively

Nanomaterials with enzyme‐mimetic activities are possible alternatives to natural enzymes. Mimicking enzymatic enantioselectivity remains a great challenge. Herein, we report that cysteine‐derived chiral carbon dots (CDs) can mimic topoisomerase I to mediate topological rearrangement of supercoiled...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-06, Vol.59 (27), p.11087-11092
Hauptverfasser:	Li, Feng, Li, Shuai, Guo, Xiaocui, Dong, Yuhang, Yao, Chi, Liu, Yangping, Song, Yuguang, Tan, Xiaoli, Gao, Lizeng, Yang, Dayong
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon - chemistry Carbon dots chiral nanomaterials Cysteine Deoxyribonucleic acid DNA DNA topoisomerase DNA Topoisomerases, Type I - chemistry DNA, Superhelical - chemistry Enantiomers Free radicals Hydrophobic and Hydrophilic Interactions Hydrophobicity Hydroxyl radicals Mimicry Molecular dynamics Nanomaterials Nanotechnology nanozymes Nucleic Acid Conformation Plasmids Stereoisomerism topoisomerase I Topology
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