Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin

In the course of screening lipopolysaccharide (LPS)-induced nitric oxide (NO) production inhibitors, two related benzodiazepine derivatives, cyclopenol and cyclopenin, were isolated from the extract of a deep marine-derived fungal strain, Aspergillus sp. SCSIOW2. Cyclopenol and cyclopenin inhibited...

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Veröffentlicht in:	Journal of antibiotics 2020-09, Vol.73 (9), p.622-629
Hauptverfasser:	Wang, Liyan, Li, Mengjie, Lin, Yinzhi, Du, Shuwen, Liu, Zhenyu, Ju, Jianhua, Suzuki, Hiromi, Sawada, Makoto, Umezawa, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 631/154/1435/2163 631/80/86 96/21 96/63 96/95 Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Animals Anti-inflammatory agents Anti-Inflammatory Agents - pharmacology Aspergillus - chemistry Bacteriology Benzodiazepinones - pharmacology Biomedical and Life Sciences Bioorganic Chemistry Cell Line Deep sea Diptera - drug effects Diptera - metabolism Disease Models, Animal Inflammation - drug therapy Inflammation - metabolism Interleukin-1beta - metabolism Learning Disabilities - drug therapy Learning Disabilities - metabolism Life Sciences Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - metabolism Medicinal Chemistry Mice Microbiology Microglia - drug effects Microglia - metabolism NF-kappa B - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Organic Chemistry RAW 264.7 Cells
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