Interleukin-18 promoter −137 G/C polymorphism (rs187238) is associated with biochemical markers of renal function and cardiovascular disease in type 2 diabetes patients

[Display omitted] •Association between −137G/C IL-18 gene polymorphism and cardiovascular disease in T2DM Brazilian population.•An increased IL-18 production in carriers of CC −137 genotype for the −137G/C polymorphism compared to the GG or GC carriers.•High creatinine and albuminuria levels were as...

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Veröffentlicht in:	Clinical biochemistry 2020-06, Vol.80, p.1-7
Hauptverfasser:	Cavalcante, Jânio Emanuel Andrade, de Sousa, Ederson Laurindo Holanda, de Oliveira Rodrigues, Raphael, de Almeida Viana, Glautemberg, Duarte Gadelha, Daniel, de Carvalho, Manoela Montenegro Dias, Sousa, Duaran Lopes, Silva, Allysson Jordan Xavier, Filho, Raimundo Rigoberto Barbosa Xavier, Fernandes, Virgínia Oliveira, Montenegro Júnior, Renan Magalhães, de Sousa Alves, Renata, Meneses, Gdayllon Cavalcante, Sampaio, Tiago Lima, Queiroz, Maria Goretti Rodrigues
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers - blood Brazil - epidemiology Cardiovascular disease Cardiovascular Diseases - epidemiology Cardiovascular Diseases - genetics Diabetes mellitus Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Female Genetic Predisposition to Disease Humans Interleukin-18 Interleukin-18 - genetics Male Middle Aged Polymorphism, Single Nucleotide Promoter Regions, Genetic Renal Insufficiency - epidemiology Renal Insufficiency - genetics Single nucleotide polymorphism
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