Interleukin-18 promoter −137 G/C polymorphism (rs187238) is associated with biochemical markers of renal function and cardiovascular disease in type 2 diabetes patients
[Display omitted] •Association between −137G/C IL-18 gene polymorphism and cardiovascular disease in T2DM Brazilian population.•An increased IL-18 production in carriers of CC −137 genotype for the −137G/C polymorphism compared to the GG or GC carriers.•High creatinine and albuminuria levels were as...
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| creator | Cavalcante, Jânio Emanuel Andrade de Sousa, Ederson Laurindo Holanda de Oliveira Rodrigues, Raphael de Almeida Viana, Glautemberg Duarte Gadelha, Daniel de Carvalho, Manoela Montenegro Dias Sousa, Duaran Lopes Silva, Allysson Jordan Xavier Filho, Raimundo Rigoberto Barbosa Xavier Fernandes, Virgínia Oliveira Montenegro Júnior, Renan Magalhães de Sousa Alves, Renata Meneses, Gdayllon Cavalcante Sampaio, Tiago Lima Queiroz, Maria Goretti Rodrigues |
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•Association between −137G/C IL-18 gene polymorphism and cardiovascular disease in T2DM Brazilian population.•An increased IL-18 production in carriers of CC −137 genotype for the −137G/C polymorphism compared to the GG or GC carriers.•High creatinine and albuminuria levels were associated with CC −137 genotype.
Interleukin-18 (IL-18), a proinflammatory and proatherogenic cytokine, has been associated with type 2 diabetes, metabolic syndrome, stroke and coronary artery disease. Some studies have indicated that the IL-18 promoter −137 G/C polymorphism seems to be associated with changes in the IL-18 expression and may contribute to the development of cardiovascular disease (CVD). The aim of this study was to evaluate the association between −137 G/C polymorphism and the levels of IL-18, biochemical markers for cardiovascular disorders, anthropometric profile and cardiovascular disease in Brazilian patients with type 2 diabetes (T2DM). Design & Methods. Study subjects comprised 125 T2DM patients undergoing follow-up at a reference endocrinology service in northeastern Brazil. The −137G/C polymorphism in the IL-18 gene and serum IL-18 levels were determined by using allele-specific polymerase chain reaction (PCR) and enzyme-linked immune assay (ELISA), respectively. The anthropometric parameters were assessed using a Body Composition Monitor with Scale, and the laboratory data were measured using an automatic analyzer as well as spectrophotometric analysis. Results. The genotype distribution of IL-18 –137 G/C genetic polymorphism was significantly different among T2DM patients with and without CVD. The results show an association between the CC genotype of −137G/C polymorphism and CVD in T2DM patients (p |
| doi_str_mv | 10.1016/j.clinbiochem.2020.03.011 |
| format | Article |
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•Association between −137G/C IL-18 gene polymorphism and cardiovascular disease in T2DM Brazilian population.•An increased IL-18 production in carriers of CC −137 genotype for the −137G/C polymorphism compared to the GG or GC carriers.•High creatinine and albuminuria levels were associated with CC −137 genotype.
Interleukin-18 (IL-18), a proinflammatory and proatherogenic cytokine, has been associated with type 2 diabetes, metabolic syndrome, stroke and coronary artery disease. Some studies have indicated that the IL-18 promoter −137 G/C polymorphism seems to be associated with changes in the IL-18 expression and may contribute to the development of cardiovascular disease (CVD). The aim of this study was to evaluate the association between −137 G/C polymorphism and the levels of IL-18, biochemical markers for cardiovascular disorders, anthropometric profile and cardiovascular disease in Brazilian patients with type 2 diabetes (T2DM). Design & Methods. Study subjects comprised 125 T2DM patients undergoing follow-up at a reference endocrinology service in northeastern Brazil. The −137G/C polymorphism in the IL-18 gene and serum IL-18 levels were determined by using allele-specific polymerase chain reaction (PCR) and enzyme-linked immune assay (ELISA), respectively. The anthropometric parameters were assessed using a Body Composition Monitor with Scale, and the laboratory data were measured using an automatic analyzer as well as spectrophotometric analysis. Results. The genotype distribution of IL-18 –137 G/C genetic polymorphism was significantly different among T2DM patients with and without CVD. The results show an association between the CC genotype of −137G/C polymorphism and CVD in T2DM patients (p < 0.001). Serum levels of IL-18 were significantly higher in CC carriers (843.1 pg/mL) compared with GG or GC carriers (303.6 pg/mL and 292.0 pg/mL, respectively). In addition, the present study showed that carriers of the CC genotype also had significantly higher concentrations of creatinine and albuminuria than carriers of the GG or GC genotypes (p < 0.05 in both). Conclusion. These results suggest that Brazilian T2DM patients with the CC genotype seem to show a predisposition to CVD, as well as an elevation in markers of renal function.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2020.03.011</identifier><identifier>PMID: 32209332</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Biomarkers - blood ; Brazil - epidemiology ; Cardiovascular disease ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - genetics ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Interleukin-18 ; Interleukin-18 - genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Renal Insufficiency - epidemiology ; Renal Insufficiency - genetics ; Single nucleotide polymorphism</subject><ispartof>Clinical biochemistry, 2020-06, Vol.80, p.1-7</ispartof><rights>2020</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-5e206a8a6f2c83bfda85e7254922838af12964562c2607e75ba8b5ae353fa6293</citedby><cites>FETCH-LOGICAL-c377t-5e206a8a6f2c83bfda85e7254922838af12964562c2607e75ba8b5ae353fa6293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000991201931135X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32209332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cavalcante, Jânio Emanuel Andrade</creatorcontrib><creatorcontrib>de Sousa, Ederson Laurindo Holanda</creatorcontrib><creatorcontrib>de Oliveira Rodrigues, Raphael</creatorcontrib><creatorcontrib>de Almeida Viana, Glautemberg</creatorcontrib><creatorcontrib>Duarte Gadelha, Daniel</creatorcontrib><creatorcontrib>de Carvalho, Manoela Montenegro Dias</creatorcontrib><creatorcontrib>Sousa, Duaran Lopes</creatorcontrib><creatorcontrib>Silva, Allysson Jordan Xavier</creatorcontrib><creatorcontrib>Filho, Raimundo Rigoberto Barbosa Xavier</creatorcontrib><creatorcontrib>Fernandes, Virgínia Oliveira</creatorcontrib><creatorcontrib>Montenegro Júnior, Renan Magalhães</creatorcontrib><creatorcontrib>de Sousa Alves, Renata</creatorcontrib><creatorcontrib>Meneses, Gdayllon Cavalcante</creatorcontrib><creatorcontrib>Sampaio, Tiago Lima</creatorcontrib><creatorcontrib>Queiroz, Maria Goretti Rodrigues</creatorcontrib><title>Interleukin-18 promoter −137 G/C polymorphism (rs187238) is associated with biochemical markers of renal function and cardiovascular disease in type 2 diabetes patients</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>[Display omitted]
•Association between −137G/C IL-18 gene polymorphism and cardiovascular disease in T2DM Brazilian population.•An increased IL-18 production in carriers of CC −137 genotype for the −137G/C polymorphism compared to the GG or GC carriers.•High creatinine and albuminuria levels were associated with CC −137 genotype.
Interleukin-18 (IL-18), a proinflammatory and proatherogenic cytokine, has been associated with type 2 diabetes, metabolic syndrome, stroke and coronary artery disease. Some studies have indicated that the IL-18 promoter −137 G/C polymorphism seems to be associated with changes in the IL-18 expression and may contribute to the development of cardiovascular disease (CVD). The aim of this study was to evaluate the association between −137 G/C polymorphism and the levels of IL-18, biochemical markers for cardiovascular disorders, anthropometric profile and cardiovascular disease in Brazilian patients with type 2 diabetes (T2DM). Design & Methods. Study subjects comprised 125 T2DM patients undergoing follow-up at a reference endocrinology service in northeastern Brazil. The −137G/C polymorphism in the IL-18 gene and serum IL-18 levels were determined by using allele-specific polymerase chain reaction (PCR) and enzyme-linked immune assay (ELISA), respectively. The anthropometric parameters were assessed using a Body Composition Monitor with Scale, and the laboratory data were measured using an automatic analyzer as well as spectrophotometric analysis. Results. The genotype distribution of IL-18 –137 G/C genetic polymorphism was significantly different among T2DM patients with and without CVD. The results show an association between the CC genotype of −137G/C polymorphism and CVD in T2DM patients (p < 0.001). Serum levels of IL-18 were significantly higher in CC carriers (843.1 pg/mL) compared with GG or GC carriers (303.6 pg/mL and 292.0 pg/mL, respectively). In addition, the present study showed that carriers of the CC genotype also had significantly higher concentrations of creatinine and albuminuria than carriers of the GG or GC genotypes (p < 0.05 in both). Conclusion. These results suggest that Brazilian T2DM patients with the CC genotype seem to show a predisposition to CVD, as well as an elevation in markers of renal function.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Brazil - epidemiology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Interleukin-18</subject><subject>Interleukin-18 - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Promoter Regions, Genetic</subject><subject>Renal Insufficiency - epidemiology</subject><subject>Renal Insufficiency - genetics</subject><subject>Single nucleotide polymorphism</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUcuO1DAQtBCIHRZ-AZnbckjWj8nriEawrLQSFzhbHaej8WxiB7ezaP6AM5_BZ_EleDUD4sip5VJ1l6uKsTdSlFLI-vpQ2sn53gW7x7lUQolS6FJI-YRtZNvoQnVaP2UbIURXdFKJC_aC6JCfatvWz9mFVkpkitqwn7c-YZxwvXe-kC1fYphDRviv7z-kbvjN9Y4vYTrOIS57RzO_ipQllG7fckcciIJ1kHDg31za8_OfnIWJzxDvMRIPI4_oMzCu3iYXPAc_cAtxcOEByK4TRD44QiDkzvN0XJCrjECPCYkvkBz6RC_ZsxEmwlfnecm-fHj_efexuPt0c7t7d1dY3TSpqFCJGlqoR2Vb3Y8DtBU2qtp2SrW6hVGqrt5WtbKqFg02VQ9tXwHqSo9Q5-Qu2dXpbs7i64qUzOzI4jSBx7CSyd51JfVW6kztTlQbA1HE0SzRZd9HI4V5rMoczD9VmceqjNAmV5V3X59l1n7G4e_mn24yYXciYDb74DAasjkIi4OLaJMZgvsPmd8cUqzL</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Cavalcante, Jânio Emanuel Andrade</creator><creator>de Sousa, Ederson Laurindo Holanda</creator><creator>de Oliveira Rodrigues, Raphael</creator><creator>de Almeida Viana, Glautemberg</creator><creator>Duarte Gadelha, Daniel</creator><creator>de Carvalho, Manoela Montenegro Dias</creator><creator>Sousa, Duaran Lopes</creator><creator>Silva, Allysson Jordan Xavier</creator><creator>Filho, Raimundo Rigoberto Barbosa Xavier</creator><creator>Fernandes, Virgínia Oliveira</creator><creator>Montenegro Júnior, Renan Magalhães</creator><creator>de Sousa Alves, Renata</creator><creator>Meneses, Gdayllon Cavalcante</creator><creator>Sampaio, Tiago Lima</creator><creator>Queiroz, Maria Goretti Rodrigues</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202006</creationdate><title>Interleukin-18 promoter −137 G/C polymorphism (rs187238) is associated with biochemical markers of renal function and cardiovascular disease in type 2 diabetes patients</title><author>Cavalcante, Jânio Emanuel Andrade ; de Sousa, Ederson Laurindo Holanda ; de Oliveira Rodrigues, Raphael ; de Almeida Viana, Glautemberg ; Duarte Gadelha, Daniel ; de Carvalho, Manoela Montenegro Dias ; Sousa, Duaran Lopes ; Silva, Allysson Jordan Xavier ; Filho, Raimundo Rigoberto Barbosa Xavier ; Fernandes, Virgínia Oliveira ; Montenegro Júnior, Renan Magalhães ; de Sousa Alves, Renata ; Meneses, Gdayllon Cavalcante ; Sampaio, Tiago Lima ; Queiroz, Maria Goretti Rodrigues</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-5e206a8a6f2c83bfda85e7254922838af12964562c2607e75ba8b5ae353fa6293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Brazil - epidemiology</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Interleukin-18</topic><topic>Interleukin-18 - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Promoter Regions, Genetic</topic><topic>Renal Insufficiency - epidemiology</topic><topic>Renal Insufficiency - genetics</topic><topic>Single nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cavalcante, Jânio Emanuel Andrade</creatorcontrib><creatorcontrib>de Sousa, Ederson Laurindo Holanda</creatorcontrib><creatorcontrib>de Oliveira Rodrigues, Raphael</creatorcontrib><creatorcontrib>de Almeida Viana, Glautemberg</creatorcontrib><creatorcontrib>Duarte Gadelha, Daniel</creatorcontrib><creatorcontrib>de Carvalho, Manoela Montenegro Dias</creatorcontrib><creatorcontrib>Sousa, Duaran Lopes</creatorcontrib><creatorcontrib>Silva, Allysson Jordan Xavier</creatorcontrib><creatorcontrib>Filho, Raimundo Rigoberto Barbosa Xavier</creatorcontrib><creatorcontrib>Fernandes, Virgínia Oliveira</creatorcontrib><creatorcontrib>Montenegro Júnior, Renan Magalhães</creatorcontrib><creatorcontrib>de Sousa Alves, Renata</creatorcontrib><creatorcontrib>Meneses, Gdayllon Cavalcante</creatorcontrib><creatorcontrib>Sampaio, Tiago Lima</creatorcontrib><creatorcontrib>Queiroz, Maria Goretti Rodrigues</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cavalcante, Jânio Emanuel Andrade</au><au>de Sousa, Ederson Laurindo Holanda</au><au>de Oliveira Rodrigues, Raphael</au><au>de Almeida Viana, Glautemberg</au><au>Duarte Gadelha, Daniel</au><au>de Carvalho, Manoela Montenegro Dias</au><au>Sousa, Duaran Lopes</au><au>Silva, Allysson Jordan Xavier</au><au>Filho, Raimundo Rigoberto Barbosa Xavier</au><au>Fernandes, Virgínia Oliveira</au><au>Montenegro Júnior, Renan Magalhães</au><au>de Sousa Alves, Renata</au><au>Meneses, Gdayllon Cavalcante</au><au>Sampaio, Tiago Lima</au><au>Queiroz, Maria Goretti Rodrigues</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-18 promoter −137 G/C polymorphism (rs187238) is associated with biochemical markers of renal function and cardiovascular disease in type 2 diabetes patients</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2020-06</date><risdate>2020</risdate><volume>80</volume><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>[Display omitted]
•Association between −137G/C IL-18 gene polymorphism and cardiovascular disease in T2DM Brazilian population.•An increased IL-18 production in carriers of CC −137 genotype for the −137G/C polymorphism compared to the GG or GC carriers.•High creatinine and albuminuria levels were associated with CC −137 genotype.
Interleukin-18 (IL-18), a proinflammatory and proatherogenic cytokine, has been associated with type 2 diabetes, metabolic syndrome, stroke and coronary artery disease. Some studies have indicated that the IL-18 promoter −137 G/C polymorphism seems to be associated with changes in the IL-18 expression and may contribute to the development of cardiovascular disease (CVD). The aim of this study was to evaluate the association between −137 G/C polymorphism and the levels of IL-18, biochemical markers for cardiovascular disorders, anthropometric profile and cardiovascular disease in Brazilian patients with type 2 diabetes (T2DM). Design & Methods. Study subjects comprised 125 T2DM patients undergoing follow-up at a reference endocrinology service in northeastern Brazil. The −137G/C polymorphism in the IL-18 gene and serum IL-18 levels were determined by using allele-specific polymerase chain reaction (PCR) and enzyme-linked immune assay (ELISA), respectively. The anthropometric parameters were assessed using a Body Composition Monitor with Scale, and the laboratory data were measured using an automatic analyzer as well as spectrophotometric analysis. Results. The genotype distribution of IL-18 –137 G/C genetic polymorphism was significantly different among T2DM patients with and without CVD. The results show an association between the CC genotype of −137G/C polymorphism and CVD in T2DM patients (p < 0.001). Serum levels of IL-18 were significantly higher in CC carriers (843.1 pg/mL) compared with GG or GC carriers (303.6 pg/mL and 292.0 pg/mL, respectively). In addition, the present study showed that carriers of the CC genotype also had significantly higher concentrations of creatinine and albuminuria than carriers of the GG or GC genotypes (p < 0.05 in both). Conclusion. These results suggest that Brazilian T2DM patients with the CC genotype seem to show a predisposition to CVD, as well as an elevation in markers of renal function.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32209332</pmid><doi>10.1016/j.clinbiochem.2020.03.011</doi><tpages>7</tpages></addata></record> |
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| ispartof | Clinical biochemistry, 2020-06, Vol.80, p.1-7 |
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| subjects | Adult Aged Biomarkers - blood Brazil - epidemiology Cardiovascular disease Cardiovascular Diseases - epidemiology Cardiovascular Diseases - genetics Diabetes mellitus Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Female Genetic Predisposition to Disease Humans Interleukin-18 Interleukin-18 - genetics Male Middle Aged Polymorphism, Single Nucleotide Promoter Regions, Genetic Renal Insufficiency - epidemiology Renal Insufficiency - genetics Single nucleotide polymorphism |
| title | Interleukin-18 promoter −137 G/C polymorphism (rs187238) is associated with biochemical markers of renal function and cardiovascular disease in type 2 diabetes patients |
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