Synthesis and evaluation of the performance of a small molecule library based on diverse tropane-related scaffolds

[Display omitted] A unified synthetic approach was developed that enabled the synthesis of diverse tropane-related scaffolds. The key intermediates that were exploited were cycloadducts formed by reaction between 3-hydroxy-pyridinium salts and vinyl sulfones or sulfonamides. The diverse tropane-rela...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2020-05, Vol.28 (9), p.115442-115442, Article 115442
Hauptverfasser:	Lowe, Robert A., Taylor, Dale, Chibale, Kelly, Nelson, Adam, Marsden, Stephen P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Antimalarials Hedgehog signalling Molecular diversity Molecular scaffolds
Online-Zugang:	Volltext
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