Efficient tailoring of platinum nanoparticles supported on multiwalled carbon nanotubes for cancer therapy
Therapeutically targeting cancer stem cells (CSCs), which play a role in tumor initiation and relapse, remains challenging. Novel-formulated platinum nanoparticles (Pt-NPs) supported on polybenzimidazole (PBI)-functionalized polymers and multiwalled carbon nanotubes (MWCNT) were prepared and their e...
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| Veröffentlicht in: | Nanomedicine (London, England) England), 2020-04, Vol.15 (8), p.793-808 |
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| creator | Berber, Mohamed R Elkhenany, Hoda Hafez, Inas H El-Badawy, Ahmed Essawy, Mohamed El-Badri, Nagwa |
| description | Therapeutically targeting cancer stem cells (CSCs), which play a role in tumor initiation and relapse, remains challenging.
Novel-formulated platinum nanoparticles (Pt-NPs) supported on polybenzimidazole (PBI)-functionalized polymers and multiwalled carbon nanotubes (MWCNT) were prepared and their effect on CSCs was evaluated.
Pt-NPs showed homogenous distribution on the surface of MWCNT/PBI composites, with very narrow particle size. MWCNT/PBI/Pt-NPs resulted in a dramatic decrease in the proliferation rate of CSCs but not bone marrow mesenchymal stem cells (BM-MSCs). Quantitative gene expression analysis revealed that MWCNT/PBI/Pt had a significant inhibitory effect on the epithelial-mesenchymal transition and cell cycle markers of CSCs.
MWCNT/PBI/Pt exhibited a specific cytotoxic effect on breast CSCs but not on adult stem cells.
An
study on the anticancer effect of novel-formulated platinum nanoparticles (Pt-NPs) supported on polybenzimidazole (PBI)-functionalized MWCNT (MWCNT/PBI/Pt-NPs) on human breast cancer stem cells (CSCs). We have demonstrated that the anticancer effect of MWCNT/PBI/Pt on CSCs may have different molecular pathway compared with cisplatin. MWCNT/PBI/Pt could induce cell cycle arrest, reduce drug resistance and inhibit DNA repair properties of breast CSCs. |
| doi_str_mv | 10.2217/nnm-2019-0445 |
| format | Article |
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Novel-formulated platinum nanoparticles (Pt-NPs) supported on polybenzimidazole (PBI)-functionalized polymers and multiwalled carbon nanotubes (MWCNT) were prepared and their effect on CSCs was evaluated.
Pt-NPs showed homogenous distribution on the surface of MWCNT/PBI composites, with very narrow particle size. MWCNT/PBI/Pt-NPs resulted in a dramatic decrease in the proliferation rate of CSCs but not bone marrow mesenchymal stem cells (BM-MSCs). Quantitative gene expression analysis revealed that MWCNT/PBI/Pt had a significant inhibitory effect on the epithelial-mesenchymal transition and cell cycle markers of CSCs.
MWCNT/PBI/Pt exhibited a specific cytotoxic effect on breast CSCs but not on adult stem cells.
An
study on the anticancer effect of novel-formulated platinum nanoparticles (Pt-NPs) supported on polybenzimidazole (PBI)-functionalized MWCNT (MWCNT/PBI/Pt-NPs) on human breast cancer stem cells (CSCs). We have demonstrated that the anticancer effect of MWCNT/PBI/Pt on CSCs may have different molecular pathway compared with cisplatin. MWCNT/PBI/Pt could induce cell cycle arrest, reduce drug resistance and inhibit DNA repair properties of breast CSCs.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm-2019-0445</identifier><identifier>PMID: 32207376</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>anticancer nanocomposite ; Biological activity ; Bone marrow ; Breast cancer ; cancer recurrence ; Cancer therapies ; Carbon ; Cell culture ; cell cycle arrest ; cytotoxicity ; Deoxyribonucleic acid ; DNA ; DNA damage ; Gene expression ; Nanoparticles ; Penicillin ; platinum nanoparticles ; polybenzimidazole ; Polymers ; Polyvinyl alcohol ; Reagents ; Solvents ; Spectrum analysis ; Stem cells</subject><ispartof>Nanomedicine (London, England), 2020-04, Vol.15 (8), p.793-808</ispartof><rights>2020 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Apr 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-9a069ef18090cd5ec29c52d601a5a6ac521c7b804d90f3dbaf0b88a1ebc59a643</citedby><cites>FETCH-LOGICAL-c371t-9a069ef18090cd5ec29c52d601a5a6ac521c7b804d90f3dbaf0b88a1ebc59a643</cites><orcidid>0000-0003-2638-8640</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32207376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berber, Mohamed R</creatorcontrib><creatorcontrib>Elkhenany, Hoda</creatorcontrib><creatorcontrib>Hafez, Inas H</creatorcontrib><creatorcontrib>El-Badawy, Ahmed</creatorcontrib><creatorcontrib>Essawy, Mohamed</creatorcontrib><creatorcontrib>El-Badri, Nagwa</creatorcontrib><title>Efficient tailoring of platinum nanoparticles supported on multiwalled carbon nanotubes for cancer therapy</title><title>Nanomedicine (London, England)</title><addtitle>Nanomedicine (Lond)</addtitle><description>Therapeutically targeting cancer stem cells (CSCs), which play a role in tumor initiation and relapse, remains challenging.
Novel-formulated platinum nanoparticles (Pt-NPs) supported on polybenzimidazole (PBI)-functionalized polymers and multiwalled carbon nanotubes (MWCNT) were prepared and their effect on CSCs was evaluated.
Pt-NPs showed homogenous distribution on the surface of MWCNT/PBI composites, with very narrow particle size. MWCNT/PBI/Pt-NPs resulted in a dramatic decrease in the proliferation rate of CSCs but not bone marrow mesenchymal stem cells (BM-MSCs). Quantitative gene expression analysis revealed that MWCNT/PBI/Pt had a significant inhibitory effect on the epithelial-mesenchymal transition and cell cycle markers of CSCs.
MWCNT/PBI/Pt exhibited a specific cytotoxic effect on breast CSCs but not on adult stem cells.
An
study on the anticancer effect of novel-formulated platinum nanoparticles (Pt-NPs) supported on polybenzimidazole (PBI)-functionalized MWCNT (MWCNT/PBI/Pt-NPs) on human breast cancer stem cells (CSCs). We have demonstrated that the anticancer effect of MWCNT/PBI/Pt on CSCs may have different molecular pathway compared with cisplatin. MWCNT/PBI/Pt could induce cell cycle arrest, reduce drug resistance and inhibit DNA repair properties of breast CSCs.</description><subject>anticancer nanocomposite</subject><subject>Biological activity</subject><subject>Bone marrow</subject><subject>Breast cancer</subject><subject>cancer recurrence</subject><subject>Cancer therapies</subject><subject>Carbon</subject><subject>Cell culture</subject><subject>cell cycle arrest</subject><subject>cytotoxicity</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Gene expression</subject><subject>Nanoparticles</subject><subject>Penicillin</subject><subject>platinum nanoparticles</subject><subject>polybenzimidazole</subject><subject>Polymers</subject><subject>Polyvinyl alcohol</subject><subject>Reagents</subject><subject>Solvents</subject><subject>Spectrum analysis</subject><subject>Stem cells</subject><issn>1743-5889</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kctrFTEUh4NUbK0u3cqAGzejSWYmj2Up1wcU3Og6ZDInmksmmeZB6X_fjLd1IXSVcw5ffhzOh9A7gj9RSvjnENaeYiJ7PI7TC3RB-Ch6Jtlw9rce-kkIeY5e53zEeBKU4FfofKAU84GzC3Q8WOuMg1C6op2PyYXfXbTd5nVxoa5d0CFuOhVnPOQu122LqcDSxdCt1Rd3p71vrdFpbqOdLnVupI2pDYOB1JU_kPR2_wa9tNpnePv4XqJfXw4_r7_1Nz--fr--uunNwEnppcZMgiUCS2yWCQyVZqILw0RPmulWE8NngcdFYjsss7Z4FkITmM0kNRuHS_TxlLuleFshF7W6bMB7HSDWrOggKONsJFNDP_yHHmNNoW2n6Cg44YJz2aj-RJkUc05g1ZbcqtO9IljtElSToHYJapfQ-PePqXVeYflHP129AfIE2Fpqgrzf34A6de1HExLgmfAH3lqYRw</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Berber, Mohamed R</creator><creator>Elkhenany, Hoda</creator><creator>Hafez, Inas H</creator><creator>El-Badawy, Ahmed</creator><creator>Essawy, Mohamed</creator><creator>El-Badri, Nagwa</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2638-8640</orcidid></search><sort><creationdate>20200401</creationdate><title>Efficient tailoring of platinum nanoparticles supported on multiwalled carbon nanotubes for cancer therapy</title><author>Berber, Mohamed R ; Elkhenany, Hoda ; Hafez, Inas H ; El-Badawy, Ahmed ; Essawy, Mohamed ; El-Badri, Nagwa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-9a069ef18090cd5ec29c52d601a5a6ac521c7b804d90f3dbaf0b88a1ebc59a643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>anticancer nanocomposite</topic><topic>Biological activity</topic><topic>Bone marrow</topic><topic>Breast cancer</topic><topic>cancer recurrence</topic><topic>Cancer therapies</topic><topic>Carbon</topic><topic>Cell culture</topic><topic>cell cycle arrest</topic><topic>cytotoxicity</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA damage</topic><topic>Gene expression</topic><topic>Nanoparticles</topic><topic>Penicillin</topic><topic>platinum nanoparticles</topic><topic>polybenzimidazole</topic><topic>Polymers</topic><topic>Polyvinyl alcohol</topic><topic>Reagents</topic><topic>Solvents</topic><topic>Spectrum analysis</topic><topic>Stem cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berber, Mohamed R</creatorcontrib><creatorcontrib>Elkhenany, Hoda</creatorcontrib><creatorcontrib>Hafez, Inas H</creatorcontrib><creatorcontrib>El-Badawy, Ahmed</creatorcontrib><creatorcontrib>Essawy, Mohamed</creatorcontrib><creatorcontrib>El-Badri, Nagwa</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Nanomedicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berber, Mohamed R</au><au>Elkhenany, Hoda</au><au>Hafez, Inas H</au><au>El-Badawy, Ahmed</au><au>Essawy, Mohamed</au><au>El-Badri, Nagwa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficient tailoring of platinum nanoparticles supported on multiwalled carbon nanotubes for cancer therapy</atitle><jtitle>Nanomedicine (London, England)</jtitle><addtitle>Nanomedicine (Lond)</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>15</volume><issue>8</issue><spage>793</spage><epage>808</epage><pages>793-808</pages><issn>1743-5889</issn><eissn>1748-6963</eissn><abstract>Therapeutically targeting cancer stem cells (CSCs), which play a role in tumor initiation and relapse, remains challenging.
Novel-formulated platinum nanoparticles (Pt-NPs) supported on polybenzimidazole (PBI)-functionalized polymers and multiwalled carbon nanotubes (MWCNT) were prepared and their effect on CSCs was evaluated.
Pt-NPs showed homogenous distribution on the surface of MWCNT/PBI composites, with very narrow particle size. MWCNT/PBI/Pt-NPs resulted in a dramatic decrease in the proliferation rate of CSCs but not bone marrow mesenchymal stem cells (BM-MSCs). Quantitative gene expression analysis revealed that MWCNT/PBI/Pt had a significant inhibitory effect on the epithelial-mesenchymal transition and cell cycle markers of CSCs.
MWCNT/PBI/Pt exhibited a specific cytotoxic effect on breast CSCs but not on adult stem cells.
An
study on the anticancer effect of novel-formulated platinum nanoparticles (Pt-NPs) supported on polybenzimidazole (PBI)-functionalized MWCNT (MWCNT/PBI/Pt-NPs) on human breast cancer stem cells (CSCs). We have demonstrated that the anticancer effect of MWCNT/PBI/Pt on CSCs may have different molecular pathway compared with cisplatin. MWCNT/PBI/Pt could induce cell cycle arrest, reduce drug resistance and inhibit DNA repair properties of breast CSCs.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>32207376</pmid><doi>10.2217/nnm-2019-0445</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-2638-8640</orcidid></addata></record> |
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| subjects | anticancer nanocomposite Biological activity Bone marrow Breast cancer cancer recurrence Cancer therapies Carbon Cell culture cell cycle arrest cytotoxicity Deoxyribonucleic acid DNA DNA damage Gene expression Nanoparticles Penicillin platinum nanoparticles polybenzimidazole Polymers Polyvinyl alcohol Reagents Solvents Spectrum analysis Stem cells |
| title | Efficient tailoring of platinum nanoparticles supported on multiwalled carbon nanotubes for cancer therapy |
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