ECM1 secreted by HER2-overexpressing breast cancer cells promotes formation of a vascular niche accelerating cancer cell migration and invasion

The tumor microenvironment is increasingly recognized as key player in cancer progression. Investigating heterotypic interactions between cancer cells and their microenvironment is important for understanding how specific cell types support cancer. Forming the vasculature, endothelial cells (ECs) ar...

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Veröffentlicht in:	Laboratory investigation 2020-07, Vol.100 (7), p.928-944
Hauptverfasser:	Steinhaeuser, Sophie Sarah, Morera, Erika, Budkova, Zuzana, Schepsky, Alexander, Wang, Qiong, Rolfsson, Ottar, Riedel, Angela, Krueger, Aileen, Hilmarsdottir, Bylgja, Maelandsmo, Gunhild Mari, Valdimarsdottir, Bryndis, Sigurdardottir, Anna Karen, Agnarsson, Bjarni Agnar, Jonasson, Jon Gunnlaugur, Ingthorsson, Saevar, Traustadottir, Gunnhildur Asta, Oskarsson, Thordur, Gudjonsson, Thorarinn
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 13/51 14/19 42/89 631/67/1347 631/80/84/2336 Angiogenesis Biotechnology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell adhesion & migration Cell culture Cell Line, Tumor Cell migration Cell Movement - genetics Crosstalk Endothelial cells Epithelial cells ErbB-2 protein Extracellular matrix Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Feedback Female Humans Laboratory Medicine Mass spectrometry Mass spectroscopy Matrix protein Medicine Medicine & Public Health Neoplasm Invasiveness - genetics Network formation Notch1 protein Pathology Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Secretome siRNA Stem cells Tumor microenvironment Tumor Microenvironment - genetics Two dimensional analysis
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